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Product Name: Phenyl Isothiocyanate
Synonyms: PITC, Isothiocyanatobenzene
Chemical Formula: C7H5NS
CAS No.: 103-72-0
Recommended Uses: Laboratory reagent, pharmaceutical intermediate, peptide sequencing agent
Supplier: Chemical distributor, laboratory supply companies
Contact Point: Emergency response number provided by supplier, local poison control center
Classification: Acute toxicity (oral, dermal, inhalation), Skin and eye irritant
GHS Label Elements: Pictogram: Exclamation mark, Skull and crossbones
Signal Word: Danger
Hazard Statements: Toxic if inhaled, swallowed, or in contact with skin. Causes serious eye and skin irritation. May cause respiratory irritation and allergic skin reactions.
Precautionary Statements: Avoid breathing vapors, wear protective gloves and goggles, use only in well-ventilated areas, wash thoroughly after handling, keep container tightly closed, keep out of reach of children
Chemical Name: Phenyl Isothiocyanate
Common Name: PITC
Concentration: 99% or higher for reagent grade
CAS Number: 103-72-0
Impurities: Minor residues from synthesis (<0.1%) may be present depending on supplier specifications
Inhalation: Move to fresh air immediately. Seek medical attention if breathing becomes difficult, symptoms develop, or are persistent. Provide oxygen if respiration is labored.
Skin Contact: Remove contaminated clothing and rinse skin immediately with copious amounts of water for at least 15 minutes. If irritation develops, seek medical advice.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing and seek prompt medical assistance.
Ingestion: Do not induce vomiting. Rinse mouth with water, keep the person calm, and contact medical help right away. If unconscious, never give anything by mouth.
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray
Specific Hazards: Can produce toxic fumes of nitrogen oxides, sulfur oxides, and carbon oxides on decomposition. Vapors may form explosive mixtures with air.
Protective Equipment: Use self-contained breathing apparatus and full protective clothing. Approach fire from upwind.
Special Procedures: Dike runoff to prevent entry into water systems. Move containers from fire area if possible without risk.
Personal Precautions: Evacuate unnecessary personnel. Equip cleanup crew with proper protective gear: gloves, goggles, chemical apron, and respirator.
Environmental Precautions: Prevent product from entering drains, waterways, or soil. Report significant spills to local authorities.
Methods for Cleanup: Absorb spill with inert material such as sand or vermiculite. Place residue in chemical waste container for disposal. Ventilate area and avoid dust or vapor formation.
Decontamination: Wash area with water and detergents after material has been picked up.
Handling: Use in a well-ventilated and controlled setting. Wear appropriate PPE. Avoid all direct contact with eyes, skin, and clothing. Do not breathe vapors or fumes.
Storage Conditions: Store in tightly sealed original container away from incompatible materials (such as strong acids, bases, or oxidizing agents). Keep storage area cool, dry, and well-ventilated.
Incompatibilities: Avoid contact with strong oxidizers, acids, bases due to potential violent reactions.
Other Conditions: Store away from food and beverages. Use dedicated tools. Clearly label area and container.
Occupational Exposure Limits: No established OSHA, NIOSH, or ACGIH exposure limits for phenyl isothiocyanate
Engineering Controls: Use local exhaust ventilation. Keep air levels below any advisory workplace exposure limits.
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile or neoprene), safety goggles, protective clothing, and, if handling outside a fume hood, use a NIOSH-approved respirator
Hygiene Measures: Wash hands before eating, drinking, or smoking. Remove contaminated clothing and wash before reuse.
Environmental Controls: Avoid environmental release. Collect contaminated water for proper disposal.
Appearance: Clear to pale yellow oily liquid
Odor: Sharp, pungent
Odor Threshold: Not available
pH: Not applicable (non-aqueous)
Melting Point: –29°C
Boiling Point: 222°C
Flash Point: 101°C (closed cup)
Flammability: Combustible
Vapor Pressure: 0.43 mm Hg at 25°C
Vapor Density: 4.2 (air = 1)
Solubility: Insoluble in water; soluble in most organic solvents
Density: 1.107 g/cm3 at 20°C
Viscosity: Not available
Partition Coefficient (log Kow): 2.89
Auto-Ignition Temperature: 475°C
Decomposition Temperature: Data unavailable
Chemical Stability: Stable at room temperature in closed containers under recommended storage
Reactivity: Reacts vigorously with strong oxidizing agents, acids, and bases. Hydrolyzes slowly in the presence of water
Hazardous Reactions: Decomposes under fire conditions, yielding toxic fumes
Conditions to Avoid: Moisture, prolonged exposure to air, sources of ignition
Incompatible Materials: Oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: Carbon oxides, sulfur oxides, nitrogen oxides, hydrogen cyanide
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (rat): 475 mg/kg. Causes severe irritation and burns to eyes, skin, and respiratory tract. Harmful if swallowed, inhaled, or absorbed through skin.
Chronic Effects: Prolonged or repeated exposure may lead to allergic skin sensitization, respiratory tract irritation, possible liver and kidney effects
Symptoms: Burning, coughing, sore throat, headache, nausea, redness of skin or eyes
Carcinogenicity/Mutagenicity: Not classified by IARC, NTP, or OSHA as carcinogenic
Other Data: No known teratogenic or reproductive effects based on available studies
Toxicity: Harmful to aquatic organisms, may cause adverse effects in the aquatic environment
Persistence and Degradability: Not readily biodegradable. Persists in environment if released
Bioaccumulation Potential: Moderate (log Kow 2.89)
Mobility in Soil: Limited, but may migrate with surface runoff in the event of a spill
Other Adverse Effects: Avoid product release to waterways, soil, and drains. Accumulation in aquatic environments may pose risk to aquatic life
Waste Treatment Methods: Neutralize and absorb with inert materials, collect in a chemical waste container for incineration at approved facility
Disposal of Container: Dispose of empty containers and packaging as hazardous waste in accordance with local, regional, and national regulations
Special Precautions: Do not dispose of into sewer systems, natural waterways, or open environment
UN Number: UN 2810
Proper Shipping Name: Toxic Liquid, Organic, n.o.s. (contains Phenyl Isothiocyanate)
Class: 6.1 (Toxic Substances)
Packing Group: III
Hazard Label: Toxic
Special Provisions: Transport with tightly sealed containers. Avoid physical damage during transit. Ship in compliance with current national and international transport regulations.
Marine Pollutant: Not classified as a marine pollutant for IMDG regulations
TSCA Status: Listed
EINECS/ELINCS Number: 203-137-7
REACH Status: Registered substance within EU
SARA Title III: Not subject to Section 313 reporting
California Proposition 65: Not listed
Other National and Regional Regulations: Subject to chemical safety assessment and notification under applicable legislation. Follow occupational exposure and environmental protection guidelines as required in place of use.
Labeling Requirement: Clearly display GHS hazard pictograms, signal words, and hazard statements on all primary, secondary, and transported containers.
