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Product Name: Phenolphthalein
CAS Number: 77-09-8
Molecular Formula: C20H14O4
Synonyms: 3,3-bis(4-Hydroxyphenyl)-1(3H)-isobenzofuranone
Manufacturer: List contact details for supplier or distributor providing phenolphthalein
Recommended Use: Laboratory reagent, acid-base indicator
Emergency Phone Number: Reference the specific number provided by supply company
Address: Physical or mailing address for supplier or responsible party
Relevant Identified Uses: Used mainly in chemical laboratories for pH testing and titration
GHS Classification: Acute toxicity (Oral, Category 4), Carcinogenicity (Category 2), Eye Irritation (Category 2A)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, Suspected of causing cancer through ingestion or prolonged exposure, Causes serious eye irritation
Precautionary Statements: Avoid breathing dust, Wash thoroughly after handling, Wear protective gloves/protective clothing/eye protection/face protection, Get medical advice if unwell
Known Hazards: May cause lung irritation, symptoms of nausea or vomiting, possible carcinogenic risk in humans
Label Elements: Pictograms for exclamation mark and health hazard
C hemical Name: Phenolphthalein
Concentration: >99% by weight
CAS Number: 77-09-8
Impurities/Additives: Trace organic residues or dust (lab grade, analytical grade specifications may note specific impurity tolerances)
Mixtures: No significant hazardous components other than phenolphthalein
Water Content: Typically anhydrous or contains trace moisture (moisture content below 2%)
Inhalation: Move exposed person to fresh air, monitor for respiratory distress, seek medical attention if symptoms such as coughing or breathing difficulty occur
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing; if skin irritation persists, consult a healthcare provider
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek ophthalmologist if eye irritation develops
Ingestion: Rinse mouth, drink water to dilute, avoid vomiting unless directed by a medical professional, call a poison center or doctor if feeling unwell
Most Important Symptoms and Effects: Nausea, abdominal pain, headache, possible allergic reaction, prolonged or repeated exposure increases risk
Immediate Medical Care Needed: For persistent symptoms or severe distress, hospitalization may be necessary
Suitable Extinguishing Media: Use water spray, dry powder, foam, or carbon dioxide
Unsuitable Media: Avoid direct water jets that may splash powdered material
Specific Hazards in Fire: Can combust to produce carbon oxides (CO, CO2), fumes of benzene derivatives, and phenolic vapors
Firefighter Protective Equipment: Use self-contained breathing apparatus, full protective gear
Additional Information: Approach from upwind, contain runoff to avoid contaminated drainage, phenolphthalein powder can create dust clouds that become explosive under certain conditions
Personal Precautions: Wear dust mask or respirator, avoid skin and eye contact, use chemical-resistant gloves and protective eyewear
Environmental Precautions: Prevent powder from entering drains, waterways, or soil; potential risk to aquatic life
Cleanup Methods: Sweep up and collect in appropriate containers; take up residue with damp cloth to minimize dust; ventilate area well
Disposal: Place spilled material in sealed, labeled waste containers for proper handling; do not flush down drain
Reference to Other Sections: Check local, regional, and national regulations for proper reporting and disposal
Safe Handling: Use non-sparking tools, ground all equipment, minimize dust generation and accumulation; do not eat, drink, or smoke when working with product
Safe Storage: Store in tightly sealed containers, keep in cool, dry, well-ventilated area, away from strong oxidizers and acids
Incompatible Materials: Avoid contact with oxidizing agents, strong acids or bases
Additional Advice: Use only with proper local exhaust or in fume hood to limit inhalation
Shelf Life: Check expiration or retest date for reliability of analytical results
Permissible Exposure Limit (PEL): No established OSHA limit; handle as nuisance dust when working with dry powder
Engineering Controls: Good general ventilation, fume hoods for large-scale use, dust control
Respiratory Protection: NIOSH-approved dust mask or respirator if dust concentrations rise
Skin Protection: Chemical-resistant gloves; lab coats or aprons; closed-toe shoes
Eye Protection: Safety goggles, face shield for large-scale handling
Other Protective Measures: Emergency eyewash station and safety shower in workspace
Appearance: White or pale pink crystalline powder
Odor: Odorless
pH (aqueous): 8.2–10.0 (as indicator in solution)
Melting Point: 260–262°C
Boiling Point: Decomposes before boiling
Flash Point: Not flammable under typical use
Solubility: Poor in water; soluble in alcohol, ether, and alkali solutions
Vapor Pressure: Negligible
Partition Coefficient (log Kow): Not readily available, low water solubility
Specific Gravity: 1.3 g/cm3
Evaporation Rate: Not applicable
Auto-ignition Temperature: Data not available
C hemical Stability: Stable under recommended handling and storage
Possibility of Hazardous Reactions: Dust accumulation may cause explosion hazard under rare conditions
Conditions to Avoid: Open flame, extreme moisture, strong oxidizing situations
Incompatible Materials: Strong oxidizers, acids, bases
Hazardous Decomposition: Produces carbon oxides, other toxic phenolic derivatives on combustion
Acute Toxicity: Oral LD50 (rat) ~ 1,200 mg/kg; toxic if ingested in large quantities
Routes of Exposure: Oral, inhalation, ocular, dermal
Possible Health Effects: Irritant to eyes, gastrointestinal symptoms after swallowing, dizziness or headache if large quantities are inhaled
Chronic Exposure: Possible carcinogenicity suggested by IARC and NTP due to animal studies, reproductive impact not fully evaluated
Symptoms of Overexposure: Abdominal pain, diarrhea, nausea, headache, rash on skin
Sensitization: No strong evidence of skin or respiratory sensitization in most users
Carcinogenicity Status: IARC: Group 2B (possibly carcinogenic to humans), NTP: Reasonably anticipated human carcinogen
Mutagenicity: Some evidence in lab animal studies, no strong human data
Other Long-Term Effects: Risks remain unclear in low exposure, more concerning in daily contact or mishandling
Ecotoxicity: Toxic to aquatic life in large amounts, not expected to bioaccumulate due to poor solubility
Persistence and Degradability: Slowly degrades; may persist under certain conditions
Bioaccumulation Potential: Low, limited by low water solubility
Mobility in Soil: Strong adsorption to soils, unlikely to travel far
Other Adverse Effects: Spilled powder can impact local water systems if not cleaned up effectively, all waste handled as chemical waste
Waste Disposal Methods: Dispose of in accordance with national and local regulations for hazardous laboratory waste
Container Disposal: Use certified hazardous waste contractor for large quantities, empty containers require triple rinse and are best disposed of as chemical waste
Special Considerations: Never pour down drain or place in regular trash, use chemical incinerator where available, keep out of waterways
UN Number: Not classified as hazardous under most transportation regulations
UN Shipping Name: Not regulated
Transport Hazard Class: Not listed
Packing Group: Not assigned
Special Precautions: Avoid generating dust, transport in sealed containers; comply with specific carrier or national guidelines for labeling
Environmental Hazards: Not classified as marine pollutant
Additional Shipping Information: Emergency spills during transport require notification to proper authorities
OSHA Status: Not regulated as hazardous chemical under OSHA Hazard Communication Standard
SARA Title III: Not listed as extremely hazardous, not subject to emergency planning
TSCA Inventory: Listed in the US TSCA inventory
European Regulation (REACH): Registered, subject to restriction as a suspected carcinogen
Canada WHMIS: Classified as controlled product, moderate hazard level
California Proposition 65: Listed substance due to potential carcinogenicity
Other National Inventories: Compliant with Japan, Australia, South Korea chemical inventories
Labeling Requirements: GHS label with health hazard, warning signal word, and hazard statements about potential cancer risk and acute toxicity
