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Product Name: Phenacyl Bromide
Chemical Formula: C8H7BrO
CAS Number: 70-11-1
Synonyms: 2-Bromoacetophenone, Bromomethyl phenyl ketone
Recommended Use: Laboratory reagent, chemical synthesis
Supplier Details: Contact local distributor or chemical supplier for emergency phone numbers, address, and availability
Classification: Acute toxicity (Oral, Dermal, Inhalation), Skin corrosion/irritation, Eye damage/irritation
Signal Word: Danger
Hazard Statements: Toxic if swallowed, inhaled, or if in contact with skin. Causes severe skin burns and eye damage. May cause respiratory irritation.
Pictograms: Skull and crossbones, Corrosive
Precautionary Statements: Avoid breathing dust, vapors, or spray. Wash exposed areas thoroughly after handling. Use only in well-ventilated space. Wear protective gloves, protective clothing, and eye protection.
Chemical Name: Phenacyl Bromide
Concentration: >98%
Impurities: Minor amounts of 2-bromotoluene, acetophenone may sometimes be present as trace impurities
EC Number: 200-713-9
Inhalation: Remove person to fresh air. Provide oxygen support if breathing is difficult. Keep airway clear. Get immediate medical attention.
Skin Contact: Wash immediately with plenty of water for at least 20 minutes. Remove contaminated clothing. Seek immediate medical advice.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if possible. Continue rinsing and seek immediate ophthalmologist care.
Ingestion: Rinse mouth with water, do not induce vomiting. Do not give anything by mouth to an unconscious person. Get medical care without delay.
Important Symptoms: Severe irritation or burns to eyes, skin, mucous membrane irritation, respiratory distress.
Suitable Extinguishing Media: Use water spray, CO2, dry chemical, or foam. Select agent suitable for surrounding material.
Specific Hazards: Liberates toxic bromine and carbon oxides under fire conditions. Vapors may be heavier than air.
Protective Equipment: Wear self-contained breathing apparatus and full protective gear. Approach fire from upwind, avoid downwind exposure.
Sensitivity: Avoid high heat and ignition sources to prevent decomposing toxic gases.
Personal Precautions: Leave area immediately for large spills, ventilate area, avoid inhalation or skin contact. Use PPE including gloves, goggles, lab coat, and mask or respirator.
Environmental Precautions: Prevent from entering drains, soil, or waterways. Notify regulatory authorities if significant volumes are released.
Cleanup Methods: Cover spill with inert absorbent (vermiculite, dry sand), gather up with non-sparking tools. Place waste in sealed, labeled container for disposal via hazardous waste facility. Decontaminate area with dilute sodium thiosulfate or sodium bisulfite solution.
Handling: Handle in fume hood or with proper local extraction. Do not breathe dust or vapors; avoid all direct exposure to skin and eyes. Wash thoroughly before breaks and after handling. Do not eat or drink when using.
Storage Conditions: Keep container tightly closed in a cool, dry, ventilated zone away from incompatible materials like strong bases and oxidizers. Store away from direct sunlight, heat, and moisture. Properly label all storage vessels.
Packaging: Store in chemical-resistant, shatterproof containers. Keep away from food and feedstuffs.
Exposure Limits: No specific OSHA or ACGIH exposure limits established. Minimize exposure as much as possible; treat as a highly toxic, corrosive agent.
Engineering Controls: Use process enclosures, local exhaust ventilation, and blast-proof fume hoods for open transfers.
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), splash-proof goggles, face shield, appropriate chemical suit/lab coat, suitable respiratory protection (full face respirator with organic vapor/acid gas cartridge if airborne exposure expected).
General Hygiene: Always change contaminated clothing. Wash hands and exposed skin thoroughly. Avoid bringing contaminated clothes home.
Appearance: White to pale yellow crystalline powder
Odor: Pungent, lachrymatory (tear-producing)
Melting Point: 50–52°C
Boiling Point: 251°C (decomposes)
Solubility: Slightly soluble in water, readily soluble in organic solvents (ether, acetone, benzene)
Vapor Pressure: Negligible at room temperature
Relative Density: 1.53 g/cm³
pH: Not applicable (non-aqueous)
Flash Point: >113°C
Auto-ignition Temperature: Not available
Partition Coefficient: log Pow ~2.1
Chemical Stability: Stable under recommended storage and handling conditions. Exposure to heat, moisture, or light can promote decomposition.
Reactive Hazard: Reacts violently with strong bases, strong oxidizers. Can cause exothermic reactions.
Hazardous Decomposition: Emits toxic bromine, HBr, carbon oxides upon heating or combustion.
Polymerization: Not expected to occur.
Routes of Exposure: Ingestion, inhalation, skin and eye contact
Acute Toxicity: LD50 (oral, rat) ~307 mg/kg. Corrosive, causes burns, severe irritation, and toxic effects on respiratory tract. Inhalation of dust or vapors may cause burning sensation, coughing, respiratory distress, pulmonary edema.
Chronic Effects: Prolonged or repeated exposure can damage skin, mucous membranes, lungs. Possible sensitization.
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA.
Other Health Effects: Strong lacrimator (induces tearing). Can cause severe eye damage, possible blindness on direct contact.
Ecotoxicity: Highly toxic to aquatic organisms. Short-term exposure decimates fish, crustaceans, and invertebrates at low concentrations.
Persistence/Degradability: Not readily biodegradable. Persistent hazard in soil and water.
Bioaccumulative Potential: Significant due to log Pow value; potential to bioaccumulate in aquatic species.
Mobility in Soil: Moderate mobility. Binds to soil organic matter but can leach in high-concentration spills.
Other Environmental Hazards: Prevent entry into the environment. Discharge to sewer or waterways contradicts environmental safety codes.
Waste Disposal: Classify as hazardous waste. Incinerate in approved facility using flue-gas scrubber to capture brominated products. Do not dump into drains, watercourses, or landfill.
Contaminated Packaging: Triple rinse containers, treat rinse as hazardous waste. Destroy packaging through licensed hazardous waste contractor.
Special Precautions: Consult local, state, or national regulations for disposal requirements. Keep material isolated until disposal to prevent accidental release.
UN Number: 2646
Proper Shipping Name: Phenacyl bromide
Hazard Class: 6.1 (Toxic substances)
Packing Group: II (Medium danger)
Label Required: Toxic (skull and crossbones), corrosive label may be required depending on mode of transport.
Special Transport Precautions: Ship in tightly closed, corrosion-resistant containers. Protect against physical damage and temperature extremes. Emergency response information easily accessible.
TSCA: Listed in the US Toxic Substances Control Act Inventory.
SARA Title III: Not classified as extremely hazardous, but reportable due to toxicity. Section 302 (EHS): No. Section 313 (TRI): No. Section 311/312: Acute health hazard, immediate hazard.
OSHA Hazard Communication: Meets hazardous chemical criteria.
REACH Status: Subject to registration, follows strict handling and notification protocols.
Other Local Regulatory Requirements: Comply with local, state, and federal safety, workplace, and environmental regulations controlling storage, handling, and disposal.
