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Product Name: Phenacetin
Chemical Name: Acetophenetidin
Synonyms: p-Ethoxyacetanilide, N-(4-Ethoxyphenyl)acetamide
CAS Number: 62-44-2
Recommended Use: Laboratory and research chemical
Manufacturer: [Manufacturer Information]
Emergency Telephone: [Emergency Contact Number]
Classification: Harmful if swallowed, suspected of causing cancer, toxic to kidneys
Signal Word: Warning
Hazard Statements: May cause cancer, harmful if swallowed, causes damage to organs through prolonged or repeated exposure
Pictograms: Health hazard, exclamation mark
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, do not eat, drink, or smoke when using this product, wear protective gloves and eye protection, if exposed or concerned seek medical advice
Routes of Exposure: Oral, dermal, inhalation
Target Organs: Kidneys, blood
Chemical Name: N-(4-ethoxyphenyl)acetamide
Common Name: Phenacetin
CAS Number: 62-44-2
Purity: ≥98%
Impurities: Usually less than 2%, typically traces of related acet- and aniline derivatives
Inhalation: Move person to fresh air. Provide artificial respiration if breathing stops. Seek medical attention.
Ingestion: Do not induce vomiting. Rinse mouth with water. If symptoms develop get medical help.
Skin Contact: Remove contaminated clothing and wash skin thoroughly with soap and water. If irritation persists consult a doctor.
Eye Contact: Rinse eyes thoroughly with plenty of water for at least 15 minutes. Lift eyelids to ensure thorough flushing. Seek medical advice if irritation remains.
Symptoms: May cause nausea, vomiting, cyanosis, headache, confusion, hemolytic anemia, kidney damage
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, carbon dioxide
Unsuitable Extinguishing Media: Strong water jet
Hazards: May emit toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective gear
Specific Hazards: Dust may form explosive mixtures with air. Thermal decomposition can release hazardous gases.
Personal Precautions: Wear appropriate protective equipment including gloves, safety goggles, and a dust mask. Avoid breathing dust.
Environmental Precautions: Prevent entry into drains, waterways, and soil.
Methods for Containment and Cleaning Up: Sweep spill up carefully, avoiding dust formation. Place in a suitable, labeled container for proper disposal. Wash spill site thoroughly after completion.
Safe Handling: Work in a well-ventilated area. Use closed systems or local exhaust. Wear personal protective equipment. Avoid contact with eyes, skin, and clothing.
Safe Storage: Store in a cool, dry, well-ventilated location away from incompatible substances such as strong oxidizers. Keep container tightly closed and labeled. Protect from heat, sparks, and open flames. Keep out of reach of children or unauthorized personnel.
Engineering Controls: Use fume hoods or local exhaust ventilation to reduce exposure.
Respiratory Protection: Use NIOSH/MSHA approved respirator if exposure limits are exceeded or if irritation is experienced.
Hand Protection: Use chemical-resistant gloves (nitrile or neoprene).
Eye Protection: Wear chemical splash goggles.
Skin and Body Protection: Wear lab coats or protective work clothing, closed shoes.
Hygiene Measures: Wash hands after handling. Do not eat, drink or smoke during use.
Appearance: White or slightly off-white crystalline powder
Odor: Odorless
Melting Point: 134-136°C
Boiling Point: 259°C (decomposes)
Solubility: Slightly soluble in water (0.07 g/100 mL at 25°C), soluble in alcohol, ether, benzene
pH: Not applicable
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): 1.58
Relative Density: Approximately 1.24 (Water = 1)
Flash Point: 150°C (closed cup)
Autoignition Temperature: 420°C
Evaporation Rate: Not determined
Chemical Stability: Stable under normal handling and storage conditions.
Conditions to Avoid: Excessive heat, open flames, static discharge, sources of ignition
Incompatible Materials: Oxidizers (e.g., peroxides, nitric acid), strong acids
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Reactivity: Not reactive under normal conditions.
Polymerization: Will not occur
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (rat): 1320 mg/kg
Chronic Toxicity: Long-term use associated with kidney damage, methemoglobinemia, carcinogenicity
Carcinogenicity: IARC Group 2B ("possibly carcinogenic to humans").
Symptoms of Overexposure: Nausea, vomiting, dizziness, cyanosis, fatigue
Target Organs: Kidney, bladder, blood
Other Effects: Hemolytic anemia in susceptible individuals; may cause allergic reactions
Mutagenicity: Some evidence in animal studies
Ecotoxicity: Harmful to aquatic organisms at high concentrations
Persistence and Degradability: Not readily biodegradable
Bioaccumulation Potential: Moderately bioaccumulative
Mobility in Soil: Slightly mobile based on solubility and log Kow
Other Adverse Effects: Spills may cause damage to aquatic environments, avoid runoff into surface waters and sewers
Waste Treatments: Incinerate in accordance with local, regional, and national regulations.
Disposal Method: Treat as hazardous waste. Use authorized chemical waste disposal contractor.
Contaminated Packaging: Handle empty containers in the same way as product, triple rinse and puncture before disposal.
Special Precautions: Do not allow product to enter environment or water courses during disposal
UN Number: Not classified as dangerous for transport
UN Proper Shipping Name: Phenacetin
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazards: Avoid discharge to environment
Special Precautions for Transport: Protect from moisture, avoid rough handling and high temperatures during transport
Global Regulations: Listed in TSCA (USA), EINECS (EU), Canada DSL, Australia AICS
OSHA: Not specifically regulated as hazardous chemical
EPA: Not listed as hazardous waste
WHMIS (Canada): D2A (Very toxic material causing other toxic effects)
EU: Classified as Carcinogen Category 2; Harmful (Xn), Risk phrases R22, R40
Other National Regulations: Substance prohibited or restricted in some countries for pharmaceutical use
Labeling Requirements: Comply with local regulations regarding carcinogenic substances
