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Product Name: Peramivir Trihydrate
Synonyms: Peramivir hydrate, RWJ-270201 trihydrate
CAS Number: 389639-12-9
Manufacturer: Pharmaceutical suppliers or chemical research entities
Recommended Use: Antiviral agent, laboratory chemical
Emergency Phone: Provided by local supplier or company distributing Peramivir
Classification: Not classed as hazardous under GHS, but good laboratory practices are necessary
Label Elements: Avoid contact with eyes, skin, and clothing; avoid inhalation or ingestion
Signal Word: None required under current regulations
Hazard Statements: May cause mild irritation to eyes, skin, or respiratory tract
Precautionary Statements: Use gloves and protective eyewear, wash hands after handling
Symptoms of Overexposure: Eye, skin, respiratory irritation, nausea in rare exposure scenarios
Chemical Name: Peramivir trihydrate
Molecular Formula: C15H28N4O12 (including water molecules)
Molecular Weight: Approx. 440.41 g/mol
Purity: Typically >98% for research and pharmaceutical use
Impurities: Trace manufacturing byproducts, not expected to be hazardous
Component Breakdown: Single active ingredient; no significant inactive fillers
Eye Contact: Rinse gently with water for at least 15 minutes; seek medical attention if irritation persists
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing
Inhalation: Move person to fresh air; seek medical attention if symptoms develop
Ingestion: Rinse mouth with water, seek medical advice with material safety information
Note to Physicians: Symptomatic treatment; supportive care recommended
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical, foam; avoid high-pressure streams
Special Hazards: Decomposition emits nitrogen oxides, carbon oxides, and possibly fluorine-containing compounds
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective suit
Advice: Prevent runoff from entering drains or water sources, cool containers exposed to flames
Flammability: Not classed as highly flammable, but may burn under intense heat
Spill Response: Use personal protective equipment, avoid creating dust
Small Spill Cleanup: Sweep or scoop up, place in properly labeled container for disposal
Large Spill Cleanup: Isolate area, ventilate, clean up with specialized HEPA filtration if required
Environmental Protection: Prevent material from reaching drains, waterways, or soil
Decontamination: Clean surfaces with soap and water, dispose of cleaning materials according to regulations
Handling: Handle in well-ventilated area with protective clothing; avoid contact with eyes, skin, and clothing; prevent inhalation of powder
Storage Conditions: Store tightly closed in a cool, dry, well-ventilated location
Incompatibilities: Strong oxidizing agents, acids, bases, and sources of extreme heat
Hygiene Measures: Wash hands before eating, drinking, or smoking after handling product
Other Guidance: Keep away from foodstuffs, children, and animals
Occupational Exposure Limits: No established limits; minimize exposure using standard chemical safety practices
Engineering Controls: Use chemical fume hood or local exhaust if dust generation possible
Respiratory Protection: Wear approved particulate filter mask if airborne dust possible
Skin Protection: Chemical-resistant gloves (nitrile, neoprene), lab coat
Eye Protection: Safety goggles with side shields or full-face shield
Work Practice Controls: Practice good housekeeping; keep container tightly closed when not in use
Appearance: White or off-white crystalline powder
Odor: Odorless or practically so
Odor Threshold: Not determined
pH: Not determined; solution may be slightly acidic or neutral
Melting Point / Range: Decomposition may occur before melting
Boiling Point / Range: Not applicable (decomposes)
Flash Point: Not determined, but not expected to pose flash hazard
Solubility: Soluble in water; sparingly soluble in some organic solvents
Vapor Pressure: Negligible at ambient conditions
Vapor Density: Not available
Density: Not precisely established, approximates to similar nucleoside analogues
Partition Coefficient: Not determined
Decomposition Temperature: Gradual breakdown at elevated temperatures
Evaporation Rate: Not applicable
Chemical Stability: Stable under recommended storage conditions, dry and cool
Possibility of Hazardous Reactions: No dangerous reactions under normal use
Conditions to Avoid: Moisture, excessive heat, open flames
Materials to Avoid: Strong oxidizers, acids, bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides when burned
Acute Toxicity: Low acute toxicity based on animal studies and pharmaceutical use
Routes of Exposure: Eye, skin contact, inhalation, ingestion
Symptoms: Mild irritation of eyes, skin, or airways, and rare cases of mild gastrointestinal upset
Chronic Toxicity: No known significant chronic risks at occupational exposure levels; animal studies did not identify carcinogenicity or mutagenic effects at low exposures
Target Organs: None identified under normal laboratory exposure
Sensitization: Not reported in studies; low sensitizing potential
Ecotoxicity: Limited information; low volumes and high water solubility imply moderate risk if released in bulk
Persistence and Degradability: Expected to degrade slowly in environment; robust degradation studies not widely published
Bioaccumulative Potential: Low, due to water solubility and molecular structure
Mobility in Soil: Likely mobile, soluble in groundwater
Other Adverse Effects: Bulk discharge should be avoided; presence of fluorine necessitates responsible disposal
Disposal Methods: Dispose of in accordance with local, regional, and national regulations; incineration preferred for quantity disposal
Container Disposal: Triple rinse and puncture empty containers before disposal as chemical waste
Special Precautions: Avoid release into environment; do not flush into surface water or drains
Regulatory Guidance: Consult local environmental authorities for permitted disposal methods
UN Number: Not regulated
Transport Hazard Class: Not classified as hazardous for transportation under ADR, IATA, or IMDG guidelines
Packing Group: Not applicable
Proper Shipping Name: Not regulated
Special Transport Precautions: Prevent damage to packaging, avoid material escape during transit
GHS Label Elements: No mandatory labeling required
OSHA: Not listed as hazardous
TSCA Status: Not listed, research and pharmaceutical use only
EU Regulations: Not a regulated substance under REACH; recommended use for research and medical manufacture only
Other Reference: Not a controlled substance; comply with local, national regulations for pharmaceutical materials
Workplace Restrictions: Use for research or clinical applications as authorized
