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Product Name: Pentoxifylline
Chemical Name: 3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
CAS Number: 6493-05-6
Recommended Use: Pharmaceutical agent for circulatory disorders
Synonyms: Oxpentifylline, Trental
Manufacturer: [Contact details provided by supplier]
Emergency Contact: [Refer to supplier SDS]
EC Number: 229-353-1
Molecular Formula: C13H18N4O3
Molecular Weight: 278.3 g/mol
Hazard Classification: Not classified as hazardous under GHS provisions
Signal Word: None applicable
Hazard Statements: May cause irritation to eyes, skin, and respiratory tract in sensitive individuals
Precautionary Statements: Avoid inhalation and contact with skin and eyes; practice good hygiene
Potential health effects: Dizziness, gastrointestinal disturbances, flushing, and headache
Routes of Exposure: Inhalation, ingestion, skin, and eyes
Symptoms of Exposure: Nausea, fatigue, mild respiratory discomfort
NFPA Ratings: Health: 1; Flammability: 1; Instability: 0
Chemical Name: Pentoxifylline
Concentration: >98% by weight
Impurities or Stabilizing Additives: Trace (<2%) residual solvents
Other Ingredients: No hazardous ingredients present at significant levels
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; seek medical attention if irritation persists
Skin Contact: Wash with soap and water; seek medical advice if symptoms occur
Inhalation: Remove victim to fresh air; seek medical attention if symptoms develop
Ingestion: Rinse mouth; consult physician if feeling unwell or large amounts ingested
Symptoms Requiring Attention: Persistent headache, gastrointestinal upset, respiratory problems
Recommendations for Physicians: Provide symptomatic and supportive treatment
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: High-pressure water jets
Specific Hazards: Burning produces irritating, toxic, and corrosive gases including nitrogen oxides, carbon monoxide, and carbon dioxide
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing
Fire-Fighting Advice: Move containers from fire area if safe; use water mist to cool closed containers
Explosion Data: Not sensitive to mechanical impact or static discharge
Personal Precautions: Wear appropriate personal protective equipment; avoid dust formation; avoid inhalation of dust
Environmental Precautions: Prevent spilled material from entering drains, sewers, or surface water
Methods for Cleanup: Collect spilled material using non-sparking tools and place in suitable labeled waste container; clean area with water after material pickup
Exposure Controls: Ensure adequate ventilation; use personal protective equipment as required
Reference to Other Sections: See sections on personal protection and disposal
Safe Handling: Handle only in areas with adequate ventilation; avoid formation of dust; wash hands after handling
Storage Conditions: Store in tightly closed container in a dry, cool, and well-ventilated place
Incompatible Materials: Strong oxidizers, acids, bases
Specific End Uses: For research and pharmaceutical preparation
Precautions for Safe Storage: Keep away from sources of ignition, heat, moisture, and direct sunlight
Storage Stability: Stable under recommended storage conditions
Occupational Exposure Limits: Not established for Pentoxifylline
Engineering Controls: Use with local exhaust ventilation to minimize exposure
Personal Protective Equipment: Eye protection (goggles or safety glasses); protective gloves (nitrile or neoprene); protective clothing as needed; approved respirator if dust arises and inhalation risk exists
General Hygiene Measures: Wash hands before breaks, after handling, and at the end of workday; avoid eating, drinking, or smoking in work areas
Environmental Exposure Controls: Prevent further leakage or spillage if safe to do so
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not available
pH: Not applicable in solid form; solution pH neutral–slightly acidic
Melting Point: 102 - 104°C
Boiling Point: Decomposes before boiling
Flash Point: Not determined due to decomposition
Evaporation Rate: Not applicable
Flammability: Not flammable under normal conditions
Vapor Pressure: Negligible at room temperature
Relative Density: ~1.4 g/cm³
Solubility: Slightly soluble in water, soluble in DMSO and ethanol
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: >180°C (with decomposition)
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage and handling conditions
Possibility of Hazardous Reactions: Does not polymerize or undergo hazardous reactions under normal conditions
Incompatible Materials: Strong oxidizers, strong acids and bases
Hazardous Decomposition Products: Emits oxides of nitrogen and carbon upon decomposition
Conditions to Avoid: Heat, sparks, open flames, and static discharge
Reactivity: Does not react strongly with water or common materials under normal use
Acute Toxicity: Oral LD50 (rat) approximately 1,770 mg/kg; may be harmful if ingested in large amounts
Inhalation: Dust may cause respiratory tract irritation
Skin Corrosion/Irritation: May cause mild skin irritation with prolonged contact
Eye Damage/Irritation: May cause eye irritation
Sensitization: Not considered to be a skin sensitizer based on available data
Chronic Effects: Long-term exposure may affect gastrointestinal, cardiovascular, and nervous systems
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, or OSHA
Mutagenicity: Not expected to cause genetic defects based on current data
Reproductive Toxicity: Evidence of embryotoxicity only at doses producing maternal toxicity; safe use determined by healthcare professional
Other Information: Headache, dizziness, mild gastrointestinal upset reported at high doses in clinical settings
Toxicity: No data showing acute aquatic or terrestrial toxicity at likely environmental concentrations
Persistence and Degradability: Expected to be moderately biodegradable in the environment
Bioaccumulative Potential: Low potential due to limited uptake from soil and water
Mobility in Soil: Some mobility due to water solubility; not expected to volatilize
Other Adverse Effects: No known significant environmental hazards reported
Aquatic Environmental Information: No significant risk of bioaccumulation in aquatic organisms
Waste Disposal Methods: Dispose in accordance with local, regional, and national regulations; incineration or landfill at approved facilities advised
Contaminated Packaging: Dispose of packaging as unused product if not clean
Additional Considerations: Avoid discharge into the environment; do not flush into surface water or sanitary sewer system
Resource Recovery: Consult waste management professional for recycling or reclamation options
UN Number: Not regulated for transport
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Environmental Hazards: Not classified as marine pollutant
Special Precautions for User: Transport in closed, upright containers; prevent spillage and dust generation
Transport Regulations: Transport according to local, federal, and international rules
TSCA Inventory Status: Listed
DSL/NDSL (Canada): Listed
EU Regulation: Registered under REACH, not classified as hazardous for supply
OSHA Regulation: Not hazardous under OSHA Hazard Communication Standard
WHMIS Classification: Not controlled
Other Regulatory Details: Pharmaceuticals regulations apply for medical-grade material
Label Requirements: Standard pharmaceutical labeling as per region
Additional Information: Workers handling Pentoxifylline should receive proper training about chemical safety and personal hygiene for pharmaceuticals
