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Product Name: Penicillin G Potassium
Synonyms: Benzylpenicillin Potassium Salt
Chemical Family: Beta-lactam antibiotics
CAS Number: 113-98-4
Intended Use: Pharmaceutical, laboratory reagent
Manufacturer: Contact your supplier or production laboratory
Emergency Contact: Refer to manufacturer’s 24-hour emergency number
Classification: Sensitizer, Harmful if swallowed or inhaled
Health Hazards: May cause allergic reactions, skin, eye, or respiratory irritation
Environmental Risks: Hazardous to aquatic environments in concentrated form
Signal Word: Warning
Hazard Statements: H302: Harmful if swallowed; H317: May cause allergic skin reaction; H334: May cause allergy or asthma symptoms
Precautionary Statements: P261: Avoid breathing dust
Pictograms: Exclamation mark, Health hazard
Chemical Name: Penicillin G Potassium
Percentage: Typically 90-100% active compound
Impurities: May include trace lactose, sodium chloride, or moisture
Other Names: Benzylpenicillin potassium, Penicillin potassium salt
Molecular Formula: C16H17KN2O4S
Molecular Weight: 372.48 g/mol
Inhalation: Move exposed person to fresh air, monitor for breathing difficulty, seek immediate medical attention if symptoms develop such as shortness of breath or wheezing
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water, do not reuse clothing until properly washed, consult a doctor in case of rash or persistent irritation
Eye Contact: Rinse eyes carefully with water for at least fifteen minutes, keep eyelids open, immediate medical attention is important for lingering discomfort
Ingestion: Rinse mouth thoroughly, never induce vomiting unless advised by poison control, seek prompt medical care if large quantities are swallowed
Most Important Symptoms: Allergic reactions, hives, swelling, difficulty breathing, dermatitis
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, water spray, foam
Special Hazards: Emits toxic fumes of nitrogen oxides, sulfur oxides under combustion
Protective Equipment for Firefighters: Full protective clothing, self-contained breathing apparatus
Specific Methods: Move containers from fire area if possible, prevent run-off from entering water bodies
Unusual Fire or Explosion Hazards: Dust from bulk powder can form explosive mixtures
Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, potassium oxides, sulfur compounds
Personal Precautions: Evacuate area, wear appropriate protective gear including gloves, mask, and goggles
Environmental Precautions: Prevent contamination of soil and waterways, avoid release into drains
Methods for Clean-Up: Sweep up without generating dust, place residue in labeled containers for disposal, ventilate area, wash spill site after cleanup
Disposal of Contaminated Materials: Treat as hazardous waste; follow local regulations
Decontamination: Area and tools should be washed with soap and copious water, wipe down all surfaces
Safe Handling Advice: Use in a chemical fume hood or well-ventilated space, avoid contact with eyes, skin, and clothing, do not inhale dust, practice good personal hygiene after use
Storage Requirements: Store in tightly closed original container, in a dry, cool, well-ventilated place, away from incompatible materials such as strong oxidizing agents
Special Storage Precautions: Protect from light, avoid excess moisture, segregate from food and drink
Incompatibilities: Acids, bases, oxidizing agents, reducing agents
Control Parameters: Occupational exposure limits not established specifically for Penicillin G Potassium; keep workplace dust concentration as low as possible
Engineering Controls: Local exhaust ventilation, safety shower and eyewash stations in immediate work area
Personal Protective Equipment: NIOSH-approved dust mask or respirator, chemical-resistant gloves (nitrile or latex), eye protection with side-shields or goggles, long-sleeved lab coat
Hygiene Measures: Wash hands before breaks and after handling, do not eat or drink in work areas
Environmental Controls: Procedures to prevent chemical release to environment during use or cleaning
Appearance: White or off-white crystalline powder
Odor: Faint, characteristic, sometimes sulfurous
Solubility: Freely soluble in water, practically insoluble in most organic solvents
pH (1% solution): 5.5 – 7.5
Melting Point: Decomposes above 200°C
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Not determined
Flash Point: Not applicable
Bulk Density: ~0.7 g/cm³
Stability: Sensitive to moisture and light
Odor Threshold: Not determined
Chemical Stability: Stable under recommended conditions
Reactivity: Reacts with strong acids, alkalis, oxidizing and reducing agents
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide, potassium oxides
Conditions to Avoid: Exposure to excessive heat, moisture, and light accelerates decomposition
Polymerization: Not known to occur
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity (oral LD50): Mouse: ~7000 mg/kg
Irritation: May irritate skin, eyes, mucous membranes
Corrosiveness: Non-corrosive
Chronic Toxicity: May cause sensitization, allergic reactions including anaphylaxis
Carcinogenicity: Not listed as a carcinogen by NTP, IARC, OSHA
Mutagenicity: Limited evidence in bacterial and animal studies
Reproductive Toxicity: No evidence in animal studies at pharmaceutical doses
Allergenicity: Potent allergen in sensitized individuals
Aquatic Toxicity: May be harmful at high concentrations, antibiotics show potential effects on aquatic microorganisms
Persistence and Degradability: Degrades under aerobic conditions, may persist briefly in soil and water before breakdown
Bioaccumulation: Unlikely due to chemical properties
Mobility in Soil: Moves readily in moist conditions, may move into waterways
Other Environmental Effects: Antibiotic activity may impact microbial ecosystems in soil and water
Precautions: Keep out of surface water and sewer systems
Waste Handling: Collect and dispose as hazardous pharmaceutical waste in accordance with local, regional, and national regulations
Waste Code: Dependent on jurisdiction, usually treated as medical chemical waste
Product: Do not discharge waste into drains or environment
Contaminated Packaging: Triple rinse and treat as hazardous, then dispose according to regulations
Recommendations: Seek guidance from local hazardous waste disposal authorities
UN/NA Number: Not regulated as a dangerous good for transport
Proper Shipping Name: Penicillin G Potassium
Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Minimize exposure to light and moisture during shipping
Environmental Hazards: None if properly packed
Transport in Bulk: Not intended for bulk transport
Inventory Status: Listed on US TSCA, EU EINECS, Canadian DSL
Labeling Requirements: Pharmaceutical labeling required for medical use
Hazard Symbols: GHS07 (exclamation) and GHS08 (health hazard)
Safety Statements: Apply appropriate workplace controls, signal word “Warning” for sensitization
International Regulations: Subject to drug and workplace safety laws in multiple jurisdictions, controlled by US FDA and EMA for human use
Workplace Regulations: OSHA hazard communication, exposure and reporting requirements
Other Information: Subject to prescription drug regulations; environmental release restrictions in some countries
