© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Pefloxacin Mesylate
Chemical Name: 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid mesylate
Synonyms: Peflacin Mesylate, Pefloxacin M
CAS Number: 70458-92-3
Molecular Formula: C17H20FN3O4·CH4O3S
Molecular Weight: 437.48 g/mol (including mesylate)
Intended Use: Pharmaceutical raw material, research use
Supplier Information: Contact details of the supplier or manufacturer that distributes this chemical, emergency number provided on container label
Hazard Class: Acute toxicity (oral, dermal, inhalation), eye irritation, skin sensitization
GHS Classification: Harmful if swallowed, causes serious eye irritation, may cause respiratory irritation
Signal Word: Warning
Hazard Statements: H302: Harmful if swallowed; H319: Causes serious eye irritation; H335: May cause respiratory irritation
Pictograms: Exclamation mark
Potential Health Effects: Inhalation and skin contact lead to irritation, headache, dizziness, or allergic skin response in some individuals; ingestion brings nausea or stomach pain; prolonged contact may create allergic reactions or impact gut bacteria
Environment Hazards: Waste or spills affect aquatic organisms, disrupt microbial ecosystems
Chemical Identity: Pefloxacin Mesylate
Concentration: 98% or higher active compound, minor impurities below 2%
Impurities: Traces of related quinolone derivates, manufacturing residuals
Additives: Free from stabilizers, fillers, or coatings unless specified for a formulated product
Eye Contact: Rinse with large amounts of water for 15 minutes, lifting eyelids; seek medical advice if redness or irritation persists
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, monitor for allergic response
Inhalation: Move person to fresh air, ensure easy breathing, consult physician if cough or irritation remains
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical personnel, immediate medical attention recommended in case of large amounts
General: Medical professionals monitor for signs of allergic response, gastrointestinal discomfort, and treat symptoms as needed
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Specific Hazards: Decomposes at high temperature, generating toxic fumes such as nitrogen oxides, sulfur oxides, halogenated compounds
Special Protective Equipment: Firefighters use self-contained breathing apparatus and protective clothing
Fire/Explosion Risk: Does not ignite easily, dust can form explosive mixtures in air, avoid open flames and high heat
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, hydrogen fluoride, sulfur dioxide
Personal Precautions: Wear gloves, goggles, lab coat, and dust mask; avoid inhalation or direct contact
Spill Handling: Ventilate area, contain with inert material such as sand, scoop up without creating dust; clean thoroughly with water and detergent
Environmental Protection: Prevent entry into waterways and soil; collect and dispose in line with regional environmental standards
Clean-Up Methods: Use non-sparking tools, place residue in appropriately labeled container for disposal
Handling: Use in a fume hood or well-ventilated area, avoid dust formation, do not handle without personal protective equipment; wash hands after handling
Storage Conditions: Store in a tightly closed container, away from moisture, direct sunlight, and incompatible substances (strong oxidizers, acids)
Storage Temperature: Keep at controlled room temperature (15-25°C)
Technical Measures: Secure in a dry, cool, locked storage area designed for pharmaceutical chemicals; keep away from food and beverages
Engineering Controls: Laboratory fume hood, local exhaust ventilation, HEPA-filtered airflow recommended
Personal Protective Equipment (PPE): Safety goggles, nitrile gloves, chemical-resistant coat, dust mask or respirator (P2 or N95 equivalent), closed shoes
Occupational Exposure Limits: Not established by OSHA, ACGIH, or NIOSH for this compound
Hygiene Measures: Wash hands, arms, and face after handling; avoid eating, drinking, or smoking during use
Appearance: White or slightly yellowish crystalline powder
Odor: Odorless or faint characteristic smell
Melting Point: 207-212°C (decomposition)
Solubility: Freely soluble in water and alcohol, slightly soluble in chloroform, practically insoluble in ether
pH (1% solution): 4.0–5.5
Boiling Point: Information not applicable for solids; decomposes before boiling
Partition Coefficient (log P): -0.1 to 0.5 (estimated)
Vapor Pressure: Negligible at standard conditions
Density: Approx. 1.5 g/cm³
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Sensitive to strong oxidizers and acids; hydrolysis possible in humid or wet conditions
Decomposition: Exposes toxic fumes under heat or fire; avoid high temperatures
Incompatible Materials: Strong acids, strong oxidizing agents, strong bases
Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (rat): 1310 mg/kg (published sources)
Skin Irritation: Causes mild irritation, rare risk of photosensitivity
Eye Effects: Severe irritation possible on direct exposure
Carcinogenicity: No confirmed carcinogenic risk based on current available studies
Mutagenicity: Negative in most standard genotoxicity assays
Other Data: Repeated exposure may alter liver or kidney function in animal studies at high concentrations; some quinolones may trigger tendon inflammation in predisposed individuals
Aquatic Toxicity: Harmful to aquatic life, EC50 (daphnia) typically under 10 mg/L
Persistence: Moderately persistent in the environment, resistant to degradation by standard wastewater treatment
Bioaccumulation: Low to moderate risk; BCF value (bioconcentration factor) not well-defined
Soil Mobility: Substantial movement in soil if spilled; binds to organic matter
Other Effects: Risk to beneficial soil bacteria, risk of antibiotic resistance gene propagation
Waste Disposal Method: Dispose through licensed hazardous waste contractor, incineration preferred for pharmaceuticals
Contaminated Packaging: Deface or destroy containers before landfill; follow local, national, and international regulations
Environmental Precautions: Do not flush into drains; avoid uncontrolled environmental dispersal
UN Number: Not classified for transport as dangerous goods by UN, IATA, IMDG standards (verify specific shipment batch and country requirements)
Proper Shipping Name: Not regulated
Hazard Class: None assigned under current transport guidelines
Packing Group: None required
Transport Precautions: Avoid temperature extremes and moisture; ship securely in well-labeled containers
Labeling: Follows GHS and OSHA Hazard Communication requirements
Inventory Status: Listed under active pharmaceutical ingredients in several national registers
SARA Title III: Not listed as a hazardous substance
TSCA: Not listed for TSCA inventory
EU Regulations: Registered in accordance with REACH for pharmaceutical manufacture and handling
Other Notes: Users ensure compliance with all health, safety, and environmental regulations in handling, storage, and waste management specific to their facility and local legal requirements
