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Product name: Pazopanib Hydrochloride
Synonyms: Votrient, GW786034B
Chemical formula: C21H23N7O2S·HCl
CAS Number: 444731-52-6
Supplier: Pharmaceutical Manufacturer or Distributor
Emergency contact: Refer to the supplier’s safety hotline for emergencies involving this substance.
Classification: Classified under GHS as hazardous for specific organ toxicity with repeated exposure, health hazard, and environmental hazard.
Label elements: Signal word: Warning, hazard pictograms for health and environmental hazards.
Hazard statements: May cause damage to organs through prolonged or repeated exposure, harmful if swallowed, toxic to aquatic life with long lasting effects.
Precautionary statements: Avoid release to the environment, do not breathe dust or powder, wash thoroughly after handling, wear suitable personal protection.
Chemical name: Pazopanib Hydrochloride
Active ingredient concentration: Typically above 98% for research or pharmaceutical-grade material.
Impurities or stabilizing additives: Usually minor excipients, details vary by manufacturer.
Molecular weight: 473.96 g/mol (free base)
Inhalation: Move person to fresh air immediately, seek medical attention if any effects occur.
Skin contact: Remove contaminated clothing, wash skin thoroughly with water and mild soap; seek medical advice if irritation develops.
Eye contact: Rinse eyes cautiously with water for several minutes, remove contact lenses if present and easy to do, seek ophthalmologist care if irritation persists.
Ingestion: Rinse mouth, do not attempt to induce vomiting unless instructed by medical personnel, seek immediate medical help showing the product label or packaging.
Suitable extinguishing media: Use alcohol-resistant foam, dry chemical powder, carbon dioxide, or water spray depending on fire location.
Special hazards: Product decomposition can release hydrogen chloride, sulfur oxides, nitrogen oxides, and carbon oxides.
Protective equipment for firefighters: Use standard protective gear including self-contained breathing apparatus and full protective clothing.
Special procedures: Prevent runoff from entering drains or watercourses.
Personal protection: Wear gloves, lab coat, suitable eye protection, and a dust respirator; avoid breathing dust.
Environmental precautions: Prevent spillage from reaching sewers or waterways.
Containment and cleanup methods: Collect the spilled powder with suitable tools or absorbents, transfer to a sealed container for disposal, ventilate the affected area.
Handling: Use in a well-ventilated space or fume hood; minimize dust generation; avoid ingestion, inhalation, and skin or eye contact.
Storage: Store in a tightly closed original container in a cool, dry, well-ventilated place, away from incompatible substances like strong oxidizers.
Hygiene measures: Wash hands thoroughly after handling and before eating or drinking, do not eat, drink, or smoke while working with the substance.
Engineering controls: Use local exhaust ventilation or process enclosures to control exposure.
Personal protective equipment: Gloves made of nitrile or other chemical-resistant material, eye protection such as safety goggles, lab coat or gown, and dust mask or respirator if dust becomes airborne.
Exposure limits: Not established for pazopanib; workplace controls should limit exposure as much as possible.
Specific hygiene practices: Do not wear contaminated clothing or jewelry outside designated work areas, always clean up work surfaces.
Appearance: White to off-white solid powder
Odor: Odorless or faint chemical smell
Odor threshold: Not determined
pH range: Not applicable in solid form
Melting point: About 224°C (435°F)
Boiling point: Not applicable (decomposes before boiling)
Solubility: Sparingly soluble in water; soluble in DMSO and other organic solvents
Partition coefficient (log P): Approximately 3.5
Vapor pressure: Not expected to be volatile
Relative density: Not determined
Viscosity: Not applicable for solid
Flash point: Not determined
Chemical stability: Stable under recommended storage conditions.
Conditions to avoid: Avoid high temperatures, open flames, or incompatible substances.
Incompatible materials: Strong oxidizing agents.
Hazardous decomposition products: Hydrogen chloride, nitrogen oxides, sulfur oxides, carbon oxides may form on thermal decomposition.
Polymerization: Product will not undergo hazardous polymerization.
Routes of exposure: Ingestion, inhalation, skin and eye contact.
Acute toxicity: Human therapeutic doses can cause hepatotoxicity and toxic effects on liver and gastrointestinal tract; animal studies indicate moderate toxicity.
Chronic effects: May produce liver injury, hematological changes, and possible carcinogenic or reproductive effects in long-term exposure.
Symptoms: Nausea, fatigue, loss of appetite, jaundice, elevated liver enzymes.
Target organs: Liver, kidneys, gastrointestinal tract.
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA, though long-term animal data are limited.
Mutagenicity and teratogenicity: Evidence of potential reproductive or developmental toxicity based on animal studies.
Aquatic toxicity: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Persistence and degradability: Not readily biodegradable.
Bioaccumulative potential: Likely to bioaccumulate due to moderate log P value.
Mobility in soil: Expected to have low mobility due to low solubility in water.
Other adverse effects: Avoid discharge into environment, consider broader ecosystem impacts linked to pharmaceutical contamination.
Waste treatment methods: Collect all waste in clearly labeled, sealed containers. Dispose of via licensed waste disposal contractor.
Contaminated packaging: Triple rinse empty containers, dispose with hazardous waste.
Special notes: Do not release to sewers, watercourses, or general municipal waste streams.
UN Number: Not regulated under UN transport rules for hazardous goods
UN proper shipping name: Not applicable
Transport hazard class: Not applicable
Packing group: Not specified
Environmental hazards: Not classified by transport authorities, but minimize release and secure packaging.
Transport precautions: Store in original packaging, prevent spillage or leakage during transit, inform courier service of shipment contents.
Labeling according to GHS: Required for hazardous chemical, must reflect risk phrases and precautions as set internationally.
OSHA hazard status: Regulated as hazardous chemical in occupational settings.
TSCA status: Not listed for non-research use.
REACH status (EU): Subject to authorization and registration requirements for manufacturers and importers.
Inventory listing: Not listed on general chemical inventories due to pharmaceutical nature.
Other regulations: Local, national, or international rules for pharmaceutical ingredients apply.
Worker safety: Implementation of risk management measures and safety training should be a priority for all workplaces handling this material.
