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Product Name: Paroxetine Hydrochloride
Chemical Formula: C19H20FNO3·HCl
Synonyms: Paxil, Paroxetine HCl
CAS Number: 78246-49-8
Recommended Use: Pharmaceutical intermediate, used as active ingredient in antidepressant medications
Supplier: Contact information provided on demand
Emergency Contact: Refer to local regulations and Poison Control
GHS Classification: Acute toxicity (oral) Category 4; Serious Eye Damage/Irritation, Category 2A; Skin Sensitization, Category 1
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes serious eye irritation. May cause allergic skin reaction.
Pictograms: Exclamation mark
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Target Organs: Central nervous system, liver
Other Hazards: Possible reproductive and developmental effects based on animal studies
Chemical Name: Paroxetine Hydrochloride
Content: >98%
Other Components: Trace manufacturing byproducts, water (≤1%)
Impurities: Paroxetine lactam, related substances < 0.5% each
Inhalation: Move to fresh air, provide oxygen if breathing is difficult, seek medical attention without delay
Skin Contact: Remove contaminated clothing, rinse skin thoroughly using soap and plenty of water, call a physician if irritation or redness develops
Eye Contact: Rinse eyes cautiously with water for 15-20 minutes; contact lenses should be removed if easy to do, get medical help
Ingestion: Rinse mouth immediately, do not induce vomiting, seek urgent medical support
Symptoms: Nausea, dizziness, confusion, skin rashes or hives, respiratory distress possible with high exposure
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Unsuitable Media: Avoid high-pressure water streams directly on the substance
Specific Hazards: May release toxic fumes of hydrogen chloride, nitrogen oxides, and carbon oxides during combustion
Protective Equipment for Firefighters: Full protective gear including self-contained breathing apparatus
Special Instructions: Use care when approaching chemical fires, isolate area, keep containers cool with water fog, prevent runoff from entering drains
Personal Precautions: Ventilate area, use appropriate personal protective equipment (PPE) including gloves and eye protection, avoid dust formation
Environmental Precautions: Prevent entry into sewers, waterways, or soil
Containment and Cleanup: Collect spillage with suitable absorbent (e.g. vermiculite), transfer to a properly labeled container, decontaminate surfaces with water and detergent
Disposal: Follow regulatory procedures for disposal of pharmaceutical chemicals and contaminated materials
Safe Handling: Work in a well-ventilated area; minimize direct physical contact, practice good hygiene and avoid inhalation or ingestion
Storage Requirements: Store in tightly closed containers, placed in a dry, cool, and well-ventilated location; keep away from incompatible materials like strong oxidizers and acids
Storage Temperature: Controlled room temperature, ideally 15-25 °C
Incompatibilities: Strong oxidizing agents, reducing agents, strong acids, and bases
Other Advice: Label all containers clearly, restrict access to trained personnel
Occupational Exposure Limits: No established limits for Paroxetine Hydrochloride; handle as a potent pharmaceutical
Engineering Controls: Use laboratory fume hood or local exhaust ventilation
Personal Protection Equipment: Protective nitrile gloves, safety glasses with side shields, laboratory coat, and in case of inadequate ventilation, a NIOSH-approved respirator
Hygiene Measures: Wash hands thoroughly after handling, avoid eating, drinking, or smoking in work area; remove contaminated clothing before leaving the workplace
Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic odor
Molecular Weight: 365.83 g/mol
pH (solution): 5-7 (1% aqueous solution)
Solubility: Freely soluble in water, sparingly soluble in ethanol, practically insoluble in chloroform
Melting Point: 120-125 °C (decomposition possible above this range)
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible at room temperature
Partition Coefficient: logP = 3.0 (free base)
Flash Point: Not relevant for solid material
Other Properties: Stable under normal conditions, may darken on exposure to light
Stability: Chemical stability maintained under recommended storage conditions
Reactivity: Non-reactive under standard laboratory conditions
Possibility of Hazardous Reactions: May react violently with strong oxidizing agents
Conditions to Avoid: Elevated temperature, moisture, strong acids or oxidizers
Hazardous Decomposition: Hydrogen chloride gas, nitrogen oxides, carbon monoxide, carbon dioxide may form during thermal decomposition
Polymerization: No risk of hazardous polymerization
Acute Toxicity: LD50 (oral, rat) approximately 200-300 mg/kg
Routes of Exposure: Inhalation, ingestion, dermal
Skin Corrosion/Irritation: Mild irritation possible; repeated exposure may cause dermatitis
Eye Damage/Irritation: Moderate to severe irritation seen in animal testing
Sensitization: Allergic skin reactions can occur with direct contact
Chronic Toxicity: Long-term exposure linked to changes in liver function, weight loss, central nervous system depression in animal models; potential reproductive toxicity evidence in rodent studies
Carcinogenicity: No human data, animal studies do not confirm significant carcinogenic risks
Ecotoxicity: Harmful to aquatic life, potential long-term adverse effects in aquatic environments
Persistence and Degradability: Expected to persist in soil and water due to slow biotic/abiotic degradation
Bioaccumulative Potential: Moderate, based on logP and structure
Mobility in Soil: May leach to groundwater in sandy or porous soils
Other Effects: Detection of trace residues from effluents in surface waters near pharmaceutical manufacturing zones
Waste Disposal Methods: Treat as hazardous pharmaceutical waste, follow local regulatory requirements; incineration preferred under controlled conditions
Container Disposal: Triple rinse containers, render unusable and dispose as chemical waste
Precautions: Prevent substance from reaching water bodies or municipal sewers; inform the waste facility the material contains hazardous pharmaceuticals
UN Number: Not regulated as dangerous goods under UN criteria
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Proper Shipping Name: Paroxetine Hydrochloride, non-hazardous for most land and air transport
Additional Precautions: Prevent container damage and spills during movement; use packaging that is leak-proof and labeled with product identification
US Regulations (OSHA): Not specifically regulated as a hazardous substance
TSCA Status: Not listed
SARA 313: Not subject to reporting
Canada WHMIS Classification: D2B (Toxic material causing other toxic effects)
Europe (REACH): Notified substance under REACH, professional use only
Other Approvals: Paroxetine and derivatives subject to prescription drug regulations; local, regional, and national requirements vary
Labeling: Ensure all containers and storage vessels bear current hazard warnings and manufacturer information
