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Product Name: Pantoprazole Sodium Synonyms: 5-(Difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole sodium salt CAS Number: 138786-67-1 Intended Use: Pharmaceutical ingredient Manufacturer Details: Obtain company information from product label Emergency Contact: Refer to local emergency numbers or supplier contact details
Classification: Not considered hazardous under GHS; avoid dust inhalation Key Hazards: May cause irritation to eyes, skin, and respiratory system; harmful if swallowed in large amounts; potential allergic reactions with repeated exposure Label Elements: No pictogram required Signal Word: None Precautionary Statements: Prevent contact with skin and eyes; wash hands thoroughly after handling; avoid generating dust
Chemical Name: Pantoprazole Sodium Purity: >98% Molecular Formula: C16H14F2N3NaO4S Molecular Weight: 405.35 g/mol Impurities: Can contain trace residual solvents or related impurities that originate in synthesis; not classified as hazardous at relevant concentrations
Inhalation: Remove person to fresh air, monitor for respiratory symptoms, seek medical attention if breathing discomfort persists Skin Contact: Wash off immediately with plenty of water and gentle soap; remove contaminated clothing and wash thoroughly before reuse Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if possible, seek medical advice for persistent irritation Ingestion: Do not induce vomiting, rinse mouth with water, seek medical attention if feeling unwell or for large accidental intake Most Important Symptoms: May include mild irritation, coughing, nausea, and, in rare cases, an allergic-type skin rash
Suitable Extinguishing Media: Use water spray, dry chemical, or carbon dioxide for small fires; foam recommended for larger fires Special Hazards: Emits toxic fumes of carbon oxides, nitrogen oxides, sulfur oxides, and fluorinated compounds at high temperatures Personal Protection: Wear self-contained breathing apparatus and protective suit; firefighters should avoid inhaling fumes Combustion Products: Irritating and toxic gases generated under fire conditions
Personal Precautions: Employ dust mask, gloves, and eye protection; evacuate unnecessary personnel and restrict access Environmental Precautions: Prevent powder from entering drains, surface water, or ground; sweep up material without generating dust Methods for Cleanup: Sweep carefully or use vacuum with HEPA filter; collect material in sealed, labeled containers for disposal Decontamination: Wash affected area with water and detergent after material removal
Precautions for Safe Handling: Handle in well-ventilated areas with measures to avoid dust creation; keep container tightly closed; avoid contact with eyes and skin Conditions for Safe Storage: Store in original, tightly sealed containers in a cool, dry, and well-ventilated location, protected from heat and direct sunlight Incompatibilities: Strong oxidizing agents, acids, and bases can cause decomposition or hazardous reactions Safe Packaging Material: Use high-integrity, labeled containers to minimize contamination and accidental exposure
Exposure Limits: No occupational exposure limits set specifically; practice industrial hygiene; limit worker exposure to dust Engineering Controls: Operate local exhaust ventilation; keep area clean to reduce airborne particulates Personal Protective Equipment: Use gloves, laboratory coats, safety glasses or goggles; dust mask or respirator for high airborne levels Hygiene Measures: Wash hands and skin thoroughly after use; keep food and drinks out of work area
Appearance: White to slightly yellowish powder Odor: Odorless Melting Point: Decomposes above 140 °C Solubility: Freely soluble in water, practically insoluble in organic solvents pH: Slightly basic in aqueous solution Partition Coefficient: Not readily available; assumed low due to high polarity Vapor Pressure: Not applicable due to non-volatile nature Other Properties: Stable under ordinary handling and storage conditions
Chemical Stability: Stable under standard room temperature and dry conditions Possibility of Hazardous Reactions: Contact with oxidizers or acids releases toxic gases Conditions to Avoid: Heat, moisture, strong oxidizing and reducing agents Hazardous Decomposition Products: May release hydrogen fluoride, sulfur oxides, nitrogen oxides, and carbon monoxide under fire or decomposition
Likely Routes of Exposure: Inhalation, ingestion, skin, and eye contact Acute Effects: May lead to mild skin or respiratory irritation; large oral doses may cause nausea or gastrointestinal discomfort Chronic Effects: Repeated exposure might trigger allergic reactions, including dermatitis; long-term health effects not expected under normal handling Toxicity Data: Oral LD50 (rat) >2000 mg/kg; not classified as acutely toxic Carcinogenicity: No evidence for carcinogenicity in humans; not listed by IARC, NTP, or OSHA
Ecotoxicity: Data scarce; potential toxicity to aquatic organisms cannot be ruled out Persistence and Degradability: Likely to persist in environment since synthetic, not inherently biodegradable Bioaccumulation: Low due to high polarity and water solubility Mobility in Soil: High water solubility suggests moderate mobility through soil Other Adverse Effects: Avoid large-scale spills to reduce possible environmental burden
Waste Treatment Methods: Dispose of material through licensed chemical disposal contractor according to local regulations Packaging Disposal: Decontaminate or incinerate empty containers in accordance with local or national regulations Environmental Warning: Do not release to sewer, surface water, or soil
UN Number: Not regulated for ground, air, or sea transport Transport Hazard Class: None Packing Group: None Special Precautions: Transport in original containers; ensure closures remain sealed; prevent movement and spillage during transit Label Requirements: Not required for non-hazardous pharmaceuticals
Regulatory Status: Approved active pharmaceutical ingredient in several regulatory jurisdictions Labeling Requirements: Not classified as hazardous; observe local pharmaceutical regulations Reporting Obligations: Comply with workplace safety legislation and product stewardship requirements International Inventories: Listed on relevant national inventories for pharmaceutical substances
