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Product Name: P-Nitrophenyl Isocyanate
Chemical Name: 4-Nitrophenyl Isocyanate
Synonyms: 1-Isocyanato-4-nitrobenzene
CAS Number: 104-12-1
Recommended Use: Industrial, laboratory chemical synthesis and research
Manufacturer: Chemical supplier information with contact details and emergency phone number
Product Code: Unique supplier code for inventory control
GHS Classification: Acute Toxicity (Oral, Dermal), Skin Irritant, Eye Damage, Respiratory Sensitizer
Label Elements: Pictogram for toxicity, safety signal words (Danger), hazard statements indicating potential for respiratory tract irritation, serious eye irritation, skin irritation, allergic skin reaction, harmful effects upon ingestion or inhalation
Hazard Statements: High potential to cause respiratory and skin sensitization, risk of serious eye damage, toxic if inhaled or ingested
Precautionary Statements: Wear protective gloves, goggles, and respirators, avoid breathing dust or vapors, avoid contact with skin and eyes, wash thoroughly after handling
Emergency Overview: Yellow crystalline solid with pungent odor that can irritate airways and skin rapidly
Chemical Identity: 4-Nitrophenyl Isocyanate
CAS Number: 104-12-1
Concentration: Greater than 99% by weight in most supplied forms
Impurities: Trace amounts of starting material such as 4-nitroaniline, solvents or processing agents from purification may be present in low parts per million
General Advice: Remove any contaminated clothing immediately, avoid further exposure
If Inhaled: Move person to fresh air at once, keep them comfortable and calm, support breathing as needed, seek medical attention if coughing, shortness of breath, or irritation persists
On Skin Contact: Wash skin right away with soap and water for at least 15 minutes, don't delay treatment, remove all accessories contaminated
Eye Contact: Rinse cautiously with water for a minimum of 15 minutes while holding eyelids open, remove contact lenses if present and easy to do, call for immediate medical assistance
If Swallowed: Rinse mouth thoroughly, don't induce vomiting, seek professional medical help immediately
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, water spray (use with caution to avoid spreading chemicals)
Specific Hazards: Fire releases irritating, toxic gases such as nitrogen oxides, carbon oxides, isocyanates vapors
Protective Equipment for Firefighters: Full protective suit with self-contained breathing apparatus, chemical-resistant gloves and boots
Unusual Fire Hazards: Heating or burning causes dangerous gaseous emissions, containers may rupture under intense heat
Advice: Isolate scene, keep unnecessary people away, control runoff water
Personal Precautions: Evacuate area, ventilate space well, avoid breathing dust or vapors, wear gloves, eye protection, respirators with organic vapor cartridges
Environmental Precautions: Prevent chemical from entering drains, surface water, or soil; inform authorities if product causes environmental contamination
Cleanup Methods: Use chemical absorbents such as sand or vermiculite to pick up spilled material, carefully scoop material to labeled disposable containers, decontaminate spill site after removal
Disposal: Collected waste must be managed in accordance with local hazardous waste regulations; do not flush to sewers
Handling: Avoid breathing vapors, dust, or fumes, keep away from sources of ignition, wear laboratory coat, nitrile gloves, goggles, and fume hood protection during transfer or reaction work
Storage: Store tightly sealed in original labeled container, keep in a cool, dry and well-ventilated area, refrigerate below 25°C if possible, protect from moisture and incompatible substances such as strong bases, acids, and oxidizers
Special Practices: Containers should be checked regularly for leaks or degradation, avoid storing large quantities in open or unmonitored spaces
Engineering Controls: Use chemical fume hood at all times, maintain negative pressure workspace, install eyewash stations and emergency showers nearby
Personal Protective Equipment: Chemical-resistant gloves, full gasket safety goggles, lab coat, long pants, respiratory protection such as NIOSH-approved mask with organic vapor cartridge where vapor formation possible
Permissible Exposure Limits: No OSHA or ACGIH TLV assigned; minimize all exposure due to toxicity and sensitizing risk observed in research
Hygiene Measures: Do not eat, drink, or smoke where chemical handled, wash hands and exposed skin before breaks and at shift end, discard contaminated clothing safely
Appearance: Yellow to pale yellow crystalline solid or powder
Odor: Pungent, irritating odor
Odor Threshold: Data not available
Melting Point: 54-56°C
Boiling Point: 135-137°C (decomposes at higher temp)
Flash Point: Approx. 176°C (closed cup)
Solubility: Slightly soluble in water, more soluble in organic solvents like acetone and DMSO
Vapor Pressure: Very low at room temperature
Density: About 1.3 g/cm³
pH: Not applicable
Other Properties: Decomposes in moisture and light
Chemical Stability: Stable in closed container away from heat, moisture, and light
Conditions to Avoid: Prolonged exposure to air, ambient moisture, high temperatures, light
Incompatible Materials: Strong acids, strong bases, amines, oxidizing agents, active metals
Hazardous Decomposition Products: Produces toxic gases including nitrogen oxides, carbon monoxide, carbon dioxide, isocyanates on heating or burning
Hazardous Reactions: May react violently with nucleophiles, bases, or water, releasing heat and hazardous vapors
Acute Toxicity: Oral toxicity in rats estimated LD50 1200 mg/kg, serious inhalation hazard observed in animal studies, severe eye and skin irritant
Skin and Eye Contact: Sensitizing, causes severe irritation and possible burns
Chronic Effects: Risk of developing allergic skin or respiratory reactions from repeated contact
Other Risks: Symptoms after exposure include coughing, wheezing, chest tightness, headache, nausea, and dermatitis
Carcinogenicity: Long-term animal or human data limited, not classified, focus on acute and sensitization risk
Ecotoxicity: Toxic to aquatic organisms, potential for long-lasting impacts in water systems
Persistence and Degradability: Not readily biodegradable in environment, hazardous transformation products can persist
Bioaccumulation: Not expected to bioaccumulate significantly, but danger exists due to stability
Mobility in Soil: Low mobility due to low water solubility, most binds to particulate matter
Other Harmful Effects: Even small releases can disrupt aquatic life; spills should be reported to proper authorities
Disposal Methods: Collect and send hazardous waste to licensed chemical disposal company; don't dump into drains, natural waters, or landfill
Packaging: Empty containers must also be treated as hazardous waste, incineration recommended after triple rinsing with compatible solvent
Environmental Notes: Follow all local, state, and federal disposal guidelines for hazardous chemical waste
Precautions: Do not attempt to neutralize until consulting chemical waste specialists
UN Number: UN2206
Proper Shipping Name: ISOCYANATES, SOLID, TOXIC, N.O.S. (P-Nitrophenyl Isocyanate)
Hazard Class: 6.1 (Toxic solids)
Packing Group: II
Label: Toxic, irritant
Special Precautions: Shipments must be clearly labeled, avoid container breakage, document emergency response procedures, restrict transport with incompatible chemicals or organic peroxides
OSHA Status: Classified as hazardous under OSHA Hazard Communication Standard
TSCA Status: Listed in the Toxic Substances Control Act inventory
SARA Title III: Immediate Health Hazard; not subject to Section 313 reporting
California Proposition 65: Not listed as a known carcinogen but handle with caution due to acute health risks
Other Local Regulation: Subject to restriction and reporting under local, state, and national chemical control laws
