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Product Name: Ozagrel Methyl Ester Chemical Family: Thromboxane A2 Synthase Inhibitor, Benzothiophene derivative Molecular Formula: C12H11NO4S Molecular Weight: 265.29 g/mol CAS Number: 84778-19-6 Synonyms: 1-(5-methyl-1,3-benzothiazol-2-yl)methyl ester Intended Use: Laboratory research, pharmaceutical intermediate Manufacturer Contact: Emergency phone numbers listed on product container, facility address and phone included with shipment Emergency Overview: Solid crystal, colorless to pale yellow, faint aromatic odor
GHS Classification: Acute Toxicity-Oral: Category 4, Skin Irritant: Category 3, Eye Irritant: Category 2B Signal Word: Warning Hazard Statements: Harmful if swallowed, causes skin irritation, causes eye irritation Precautionary Statements: Avoid breathing dust, wear appropriate PPE, wash hands after handling, do not eat or drink near work area Health Hazards: Prolonged exposure may affect central nervous and circulatory systems, sensitizing in some individuals Environmental Hazards: May be harmful to aquatic life; avoid contamination of soil and water Target Organs: Liver, kidneys, and mucous membranes Emergency Overview: Direct contact causes mild to moderate irritation to skin and eyes, dust inhalation may cause respiratory discomfort
Chemical Identity: Ozagrel Methyl Ester Purity: ≥98% Impurities: Trace synthesis byproducts, ≤2% Chemical Formula: C12H11NO4S Hazardous Components: Ozagrel Methyl Ester (as listed above) Other Ingredients: None deliberately added Concentration: Bulk supplied as neat substance, secondary dilution possible in research
Inhalation: Move affected individual to fresh air, keep warm and quiet, seek medical advice for persistent symptoms Skin Contact: Wash area thoroughly with soap and water for several minutes, remove contaminated clothing Eye Contact: Flush gently with running water for at least 15 minutes, keep eyelids apart, consult physician if irritation persists Ingestion: Rinse mouth with water, do not induce vomiting, seek medical help if feeling unwell Note To Physicians: Treat symptomatically, monitor for respiratory or organ complications, no specific antidote noted Special Instructions: Take product container/label to medical staff for information
Suitable Extinguishing Media: Foam, dry powder, carbon dioxide, water spray Extinguishing Media To Avoid: Direct water stream may scatter powder Special Hazards: Thermal decomposition may release nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide Special Protective Equipment: Wear self-contained breathing apparatus and suitable protective clothing Firefighting Instructions: Use water spray to cool containers, avoid inhalation of combustion products, evacuate area if necessary Sensitivity to Static Discharge: Not expected under normal use Explosion Data: No explosion hazard identified under normal handling Unusual Fire Hazards: Fine dust may form explosive mixtures with air
Personal Precautions: Use proper PPE including gloves, goggles, respirator Environmental Precautions: Prevent entry to drains, surface water, and soil Spill Cleanup Methods: Gently sweep or vacuum up using equipment with HEPA filtration, avoid generating dust, collect in labeled container for disposal Decontamination: Clean surfaces with detergent solution and water, ventilate area Large Spills: Arrange for immediate containment, notify appropriate response teams, prevent environmental release Waste Disposal: Dispose of recovered material in accordance with federal, state, and local regulations Reporting: Notify supervisors and document spill as per lab safety protocol
Handling: Use only in well-ventilated workspaces, minimize dust formation, avoid contact with skin, eyes, and clothing, do not ingest Safe Handling Practices: Avoid open flames and sources of ignition, use non-sparking tools, handle away from incompatible materials Storage Conditions: Store in tightly closed container, in cool, dry, well-ventilated place Temperature Sensitivity: Maintain at 2-8°C, protect from direct sunlight, keep away from heat and moisture Incompatibilities: Strong oxidizing agents, acids, alkalis Specific Use Considerations: Restrict access to trained personnel, maintain good housekeeping in storage and use areas Transport Precautions: Securely label and seal all containers, prevent mechanical damage during storage and movement
Engineering Controls: Use chemical fume hood or local exhaust, maintain negative air pressure, install dust collection systems Occupational Exposure Limit: No specific exposure limits established; minimize airborne concentration as good lab practice Respiratory Protection: Use NIOSH-approved respirator if airborne dust is generated, otherwise, ensure adequate ventilation Skin Protection: Wear chemical-resistant gloves, laboratory coat, and closed-toe shoes Eye/Face Protection: Chemical splash goggles or face shield when risk of eye contact exists Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing before entering eating areas Environmental Controls: Prevent release to environment, capture fugitive dust at source
Appearance: Solid, crystalline powder Color: Pale yellow to off-white Odor: Mild, characteristic Odor Threshold: Data not available pH: Not applicable (solid sample) Melting Point/Range: 122-125°C Boiling Point: Decomposes before boiling Flash Point: Data not available, estimated >100°C Flammability: Not highly flammable, may become combustible as fine dust Vapor Pressure: Negligible at room temperature Solubility: Slightly soluble in water, soluble in organic solvents (methanol, DMSO, ethanol) Partition Coefficient: logP estimated 2.0–2.5 Decomposition Temperature: >180°C Viscosity: Not applicable (solid) Density: Not available, estimated in range of 1.2–1.3 g/cm3
Chemical Stability: Stable under recommended storage conditions, sensitive to prolonged exposure to light and air Reactive Properties: Can react with strong oxidizers, acids or bases leading to hazardous byproducts Hazardous Reactions: No dangerous polymerization expected under standard handling Decomposition Products: Oxides of carbon, nitrogen, and sulfur on combustion or thermal breakdown Conditions to Avoid: High temperatures, open flames, incompatible chemicals Shelf Life: 2 years if stored correctly in original packaging Incompatibility: Avoid mixing with alkali metals, peroxides
Acute Toxicity: Oral LD50 in rodents: 400–800 mg/kg (estimated value), low acute toxicity in small-scale exposures Skin Corrosion/Irritation: Mild to moderate irritation during repeated, prolonged exposure Eye Damage/Irritation: Moderate eye irritant, suggest prompt eye wash if exposed Respiratory Sensitization: Possible irritation to throat or nasal membranes if inhaled as dust Carcinogenicity: No data supporting carcinogenic classification, not listed by IARC, NTP, ACGIH, OSHA Reproductive Toxicity: No conclusive studies, possible developmental toxicity cannot be excluded, precaution advised for pregnant workers Mutagenicity: Limited evidence available, handle with care to avoid unnecessary exposure Chronic Effects: Repeated exposure may affect liver, kidney or central nervous system after high doses in animal models Medical Conditions Aggravated: Preexisting liver, kidney, or respiratory system disorders may be aggravated
Ecotoxicity: Data on aquatic toxicity limited, expected low acute toxicity to fish and daphnia at reasonable lab release levels Persistence and Degradability: Not readily biodegradable, decomposition mainly via photolysis and microbial action Bioaccumulation Potential: Moderate potential, logP suggests possibility of some bioaccumulation Mobility in Soil: Moderate mobility, bound by organic soil matter Other Adverse Effects: Avoid uncontrolled release to water systems, no known significant ozone depletion or greenhouse effects Precautionary Measures: Waste containment and treatment recommended to limit environmental consequences Regulatory Class: Not classified as hazardous waste by federal environmental standards, specific local restrictions possible
Waste Disposal: Dispose of material as hazardous waste via licensed contractor, incineration recommended if practical Container Disposal: Triple rinse containers, puncture and dispose in compliance with local waste authority requirements Contaminated Packaging: Treat as hazardous residue, send for specialized disposal Special Instructions: Do not attempt to discharge to regular sewage or municipal waste streams Legal Disposal Requirements: Comply with all applicable environmental and safety legislation on chemical substances Document Retention: Keep records of disposal route and waste volumes as required under chemical safety laws
UN Number: Not regulated under standard UN transport codes Transport Hazard Class: Not classified as dangerous goods under ADR, ICAO, IATA, IMDG Packing Group: N/A Marine Pollutant: No Special Transport Notes: Store in secure, labeled containers during transport, protect from mechanical shock and moisture Shipping Description: Chemical, non-hazardous under standard transport guidelines; ship with supporting documentation and safety labels Emergency Transport Measures: Provide MSDS and emergency contact information with shipment
OSHA Status: Regulated under Hazard Communication Standard, chemical hazard present TSCA Inventory: Ozagrel Methyl Ester may not be listed, use restricted to research only DSL/NDSL (Canada): Not listed WHMIS Classification: Not classified as controlled product European Union Directives: Not listed on REACH candidate list, standard workplace chemical safety applies Labeling Requirements: GHS labels, hazard pictograms, signal word and precautionary statements mandatory SARA Title III: Not subject to threshold planning quantities or reporting Other Information: Product use limited to professional, trained users in accordance with local, state, and federal regulations Worker Protection: Employers must provide proper training, PPE, and exposure controls as part of lab safety program
