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Product Name: Oxytetracycline Hydrochloride
Chemical Formula: C22H24N2O9 • HCl
CAS Number: 2058-46-0
Synonyms: Terramycin Hydrochloride, OTC HCl
Recommended Use: Antibiotic agent for veterinary and laboratory applications
Manufacturer Contact: Available on commercial invoicing and packaging
Emergency Phone Number: Refer to local poison control centers
Classification: Eye irritation, Skin sensitizer, Target organ toxicity after repeated exposure
GHS Label Elements: Warning, exclamation mark symbol
Hazard Statements: May cause allergic skin reaction, causes serious eye irritation, may cause respiratory irritation, possible damage to organs through prolonged or repeated exposure
Precautionary Statements: Handle in a well-ventilated area, avoid breathing dust, wear protective gloves and eye protection, do not eat or drink during use
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Chemical Name: Oxytetracycline Hydrochloride
Percentage: 100% (technical or pharmaceutical grade)
Impurities: Levels generally below regulatory thresholds, may include trace residues from synthesis
Other Additives: No common additives for analytical or raw material supplies used in manufacturing
Inhalation: Move person to fresh air immediately, provide oxygen if respiration is difficult, contact emergency medical services
Skin Contact: Rinse skin with soap and water for at least 15 minutes, remove contaminated clothing
Eye Contact: Flush eyes with running water for several minutes, lift upper and lower eyelids, seek medical attention
Ingestion: Rinse mouth with water, seek immediate medical advice, do not induce vomiting unless instructed by poison control
Most Important Symptoms: Burning sensation, redness, itching, rash, respiratory discomfort
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Media: Direct water jet due to potential for spreading material
Hazards: Combustion releases oxides of carbon, nitrogen compounds, hydrochloric acid gas
Protective Equipment: Self-contained breathing apparatus, protective clothing resistant to chemical splatter
Firefighting Procedures: Evacuate personnel, contain run-off, avoid smoke inhalation
Personal Precautions: Wear splash-proof goggles, nitrile gloves, dust mask or respirator
Environmental Precautions: Prevent release into drains, watercourses, or soil
Methods for Cleanup: Collect spilled material using absorbent inert material, place in labeled waste container, ventilate the area well, clean surfaces with water and detergent
Disposal: Dispose in compliance with local disposal regulations
Safe Handling: Use chemical fume hood when handling powder or dust, avoid direct skin and eye contact, use no eating, drinking, or smoking in workspace
Storage Conditions: Store in tightly sealed original container, cool, dry, well-ventilated area, out of direct sunlight
Incompatibilities: Strong oxidizing agents, alkalis, acids, moisture
Specific Practice: Rotate stock to maintain freshness and potency
Exposure Limits: No regulated occupational limits recorded; handle as potential sensitizer
Engineering Controls: Provide exhaust ventilation, use laboratory containment systems
Personal Protection: Chemical resistant gloves, lab coat, safety glasses with side shields or goggles
Respiratory Protection: NIOSH/MSHA approved respirator in situations with dust or insufficient ventilation
Hygiene Measures: Wash hands after handling, remove contaminated clothing immediately
Appearance: Yellow to light brown crystalline powder
Odor: Mild, slightly medicinal
Odor Threshold: Not determined
pH: 2.0 – 3.0 (1% aqueous solution)
Melting Point: Decomposes above 210°C
Boiling Point: Not applicable (decomposes prior to boiling)
Solubility: Readily soluble in water, slightly soluble in ethanol, insoluble in chloroform and ether
Flash Point: Not flammable
Vapor Pressure: Negligible at room temperature
Partition Coefficient (Log Kow): Data not available
Density: Approximately 1.8 g/cm³ at 25°C
Chemical Stability: Stable under normal temperature and pressure, degrades on prolonged exposure to light, humidity, or elevated temperature
Conditions to Avoid: High moisture, temperature extremes, direct sunlight, incompatible substances
Incompatible Materials: Strong oxidizing agents, alkalis, acids, reducing agents
Decomposition Products: Toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride
Reactivity: No known dangerous reactions under normal use conditions, risk increases with improper storage
Acute Toxicity: Oral LD50 in rats approx. 5000 mg/kg, low acute toxicity in mammals
Chronic Effects: Prolonged exposure may cause altered liver and renal function, hypersensitivity reactions, photosensitization
Skin and Eye Contact: May produce irritation, redness, allergic reaction
Inhalation: Dust may irritate respiratory tract, possible allergic asthma
Carcinogenicity / Mutagenicity: Not classified as a carcinogen by IARC, OSHA, or NTP
Other Effects: Use over long times in animals and humans can cause changes to gut flora, superinfections
Aquatic Toxicity: Harmful to aquatic life, impacts microorganisms, may lead to antibiotic resistance in aquatic environments
Mobility in Soil: Moderately mobile, binds to clay and organic matter
Persistence and Degradability: Biodegradable under certain conditions, degradation slows in anaerobic environments
Bioaccumulation Potential: Low potential for bioaccumulation
Ecological Concerns: Discharge into waterways increases risk of resistant bacteria, disturbs balance in aquatic systems
Disposal Method: Collect and incinerate in accordance with local environmental regulations
Contaminated Packaging: Rinse containers, dispose as chemical waste
Special Precautions: Avoid runoff into sewage, waterways, or ground water
Waste Codes: None assigned specifically, consult chemical waste guidelines for antibiotics or pharmaceuticals
UN Number: Not classified as hazardous for transport
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Labeling Requirements: Standard labeling for bulk pharmaceuticals, no dangerous goods placards required
Environmental Hazards: No special transport precautions but minimize spillage, avoid unintentional release during handling
Global Inventories: Listed in U.S. TSCA, European EINECS, and other chemical inventories
OSHA: Considered hazardous based on potential for respiratory and skin sensitization
WHMIS (Canada): Classified as D2B (toxic material causing other effects)
REACH (EU): Registration required for bulk import, subject to review under antimicrobials regulations
Other Regulations: Governing conditions for use in pharmaceuticals, veterinary medicine, requires permits in some jurisdictions
