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Product Name: Oxybendazole
Chemical Name: Methyl 5-(phenylthio)-2-benzimidazolecarbamate
Synonyms: Benzimidazole-2-carbamic acid methyl ester, Oxyfenazole
CAS Number: 20559-55-1
Recommended Use: Veterinary anthelmintic, dewormer for livestock and horses
Manufacturer: Major agrochemical companies and veterinary pharmaceutical producers
Emergency Contact: Refer to local poison control or company emergency number available on packaging
Classification: Harmful if swallowed, may cause irritation to eyes and skin. Suspected of damaging fertility or the unborn child. May cause respiratory irritation on inhalation of dust. Toxic to aquatic life with long lasting effects.
Signal Word: Warning
Hazard Statements: Harmful if ingested. Causes skin and eye irritation. May cause an allergic skin reaction. May damage fertility or the unborn child. Dangerous to aquatic life with prolonged effects.
Precautionary Statements: Avoid breathing dust, wear protective gloves and eye protection, wash hands thoroughly after handling, use only outdoors or in a well-ventilated area, avoid release to the environment.
Chemical Name: Oxybendazole
Concentration: 95% or greater (technical grade)
Impurities: Byproducts from synthesis including residual solvents and minor degradation products
Formula: C13H10N2O3S
Molecular Weight: 274.30 g/mol
Inhalation: Move to fresh air immediately. If breathing becomes difficult, provide oxygen or seek medical attention.
Skin Contact: Remove any contaminated clothing, wash skin with soap and water, seek medical advice if irritation develops.
Eye Contact: Rinse cautiously with water for at least 15 minutes, keep eyelids open and remove contact lenses, consult a doctor if discomfort persists.
Ingestion: Rinse mouth, do not induce vomiting, give water to drink if conscious, seek immediate medical attention.
Most Important Symptoms: Gastrointestinal upset, skin or eye redness, shortness of breath, headache.
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray.
Special Hazards: May produce hazardous fumes including carbon monoxide, sulfur oxides, and nitrogen oxides.
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective clothing.
Precautions: Avoid inhaling smoke, run-off from fire control may pollute water sources.
Personal Precautions: Use appropriate respiratory and skin protection, prevent spread of dust.
Spill Cleanup: Use methods that minimize dust generation, collect material into secure containers for disposal, vacuum or sweep up. Decontaminate area and tools with soap and water.
Environmental Precautions: Prevent material from entering drains, surface water or ground water. Notify environmental authorities if large spill occurs.
Handling: Use with adequate ventilation, avoid breathing dust, do not eat or smoke during handling, prevent contact with skin, eyes, and clothing.
Protection: Wear suitable protective equipment and wash hands thoroughly after handling.
Storage: Store in tightly closed original containers in cool, dry, well-ventilated areas away from food, feed, or drinking water. Keep away from incompatible substances such as strong acids and bases.
Workplace Exposure Limits: No specific occupational exposure limits established for oxybendazole.
Engineering Controls: Provide local exhaust or general ventilation to minimize exposure.
Personal Protective Equipment: Gloves (nitrile or neoprene), chemical splash goggles, protective clothing, and respiratory protection if dust is present.
Hygiene Measures: Change out of clothing and wash thoroughly after use to avoid chronic exposure.
Appearance: White to light beige crystalline powder
Odor: Slight, characteristic
Solubility in Water: Low (0.24 mg/L at 20°C)
Melting Point: 179-181°C
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible at ambient temperature
Flash Point: Not readily flammable
Density: 1.36 g/cm³
Stability: Stable under normal temperatures and pressures
pH (1% solution): Slightly acidic to neutral (5.5–7.0)
Chemical Stability: Product remains stable under normal storage and handling.
Conditions to Avoid: Excess heat, exposure to strong oxidizers, intense light.
Hazardous Reactions: Does not react dangerously in normal use but can form toxic/irritant gases on combustion.
Incompatible Materials: Strong acids, alkalis, strong oxidizing agents.
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, carbon monoxide, and carbon dioxide.
Acute Toxicity: Oral LD50 in rats ranges between 2,000–3,000 mg/kg.
Skin and Eye Contact: May cause mild irritation. Sensitization reported in susceptible individuals.
Respiratory Sensitization: Dust inhalation can lead to coughing/shortness of breath.
Long-Term Effects: Studies in animals suggest possible teratogenic effects at high doses, not classified as carcinogenic.
Other Risks: Repeated exposure can affect liver function and blood parameters in laboratory settings.
Aquatic Toxicity: Very toxic to aquatic organisms with long-term persistence, LC50 (fish, 96hr): ~0.5 mg/L.
Environmental Fate: Strong absorption to soil, unlikely to leach but degrades slowly.
Bioaccumulation: Potential moderate risk due to low water solubility and persistence.
Mobility: Low in soil, risk of run-off exists if not contained.
Degradability: Breakdown in environment takes several weeks to months under typical agricultural conditions.
Waste Disposal: Collect material and residues, dispose through licensed hazardous waste disposal contractors according to local and national regulations.
Container Disposal: Triple rinse, crush or puncture to prevent reuse, then dispose following environmental guidelines.
Environmental Precautions: Do not discharge untreated waste into drains, surface or groundwater.
UN Number: Not classified as dangerous for transport under UN recommendations.
Transport Hazard Class: Not regulated for ground or air transport in most jurisdictions.
Packing Group: Not assigned
Special Precautions: Ensure packages are sealed, labeled, and protected from physical damage. Secure from leaks in transport vehicles.
Labeling Requirements: Must include hazard warning, product identification, safety instructions.
Regulatory Status: Registered for veterinary and livestock use in many countries under relevant pesticide and veterinary medicine authorities.
Other Regulations: Restrictions may apply for sale or use based on environmental impact (check national and local authorities).
International Inventories: Listed in US EPA, EU REACH, Australian APVMA, Canadian PMRA chemical inventories, along with various Asian and South American regulatory lists.
