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Material Safety Data Sheet for Ornidazole

1. Identification

Product Name: Ornidazole
Chemical Name: (S)-1-Chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
CAS Number: 16773-42-5
Molecular Formula: C7H10ClN3O3
Intended Use: Veterinary and human pharmaceutical, antiprotozoal and antibacterial agent
Supplier Information: Contact details of the manufacturing company or distributor
Emergency Contact: Regional poison control center or supplier emergency helpline
Synonyms: 1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)-2-propanol

2. Hazard Identification

GHS Classification: Acute toxicity (Oral) Category 4, Skin irritation Category 2, Eye irritation Category 2A, Specific target organ toxicity (single exposure) Category 3
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation
Precautionary Statements: Wear protective gloves, wash hands thoroughly after handling, avoid breathing dust or fumes, use only outdoors or in a well-ventilated area, store locked up
Potential Health Effects: Irritation of respiratory tract, skin, eyes; headache, dizziness, gastrointestinal discomfort upon ingestion
Routes of Entry: Inhalation, skin and eye contact, ingestion
Pictograms: Exclamation mark

3. Composition / Information on Ingredients

Chemical Composition: Ornidazole 98–100% by weight
Impurities: Less than 2%, may include residual solvents or synthetic intermediates
Other Ingredients: None significant for classification purposes
Unique Identifiers: CAS: 16773-42-5; EINECS: 240-744-6

4. First Aid Measures

Inhalation: Move person to fresh air, support breathing, seek medical attention if symptoms persist or worsen
Skin Contact: Immediately wash exposed skin with plenty of water and soap, remove and wash contaminated clothing, consult doctor if skin irritation emerges
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy to do, continue rinsing, obtain medical assistance
Ingestion: Rinse mouth thoroughly with water, do not induce vomiting, drink water if conscious, get medical evaluation at once
Most Important Symptoms: Stinging, redness, nausea, dizziness, breathing discomfort

5. Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Media: Strong water jets
Specific Fire Hazards: May produce hazardous fumes such as hydrogen chloride, nitrogen oxides, and carbon oxides in fire conditions
Protective Equipment: Firefighters should use approved self-contained breathing apparatus and full protective clothing
Special Procedures: Remove personnel from area, suppress dust, use water spray to cool nearby containers

6. Accidental Release Measures

Personal Precautions: Avoid dust formation and contact with skin or eyes, use protective equipment including gloves and goggles
Environmental Precautions: Prevent spillage into drains, watercourses, and soil
Methods for Clean-up: Sweep up or vacuum spillage using tools that do not create dust, collect in a dry clean container for disposal, ventilate the area thoroughly
Decontamination Procedure: Wash area with water following cleanup, dispose of wash water according to local regulations

7. Handling and Storage

Handling: Avoid the generation of dust, do not breathe dust, use with local exhaust ventilation, keep away from food, drinks, and animal feed, wash hands before breaks and at end of workday
Storage Conditions: Store in a tightly closed container in a cool, dry, well-ventilated place, protect from light and moisture, keep away from incompatible materials such as strong oxidizing agents
Incompatibilities: Reactive with strong acids, bases, and strong oxidizers
Hygiene Measures: Do not eat, drink, or smoke during use, wash contaminated clothing before reuse

8. Exposure Controls and Personal Protection

Control Parameters: Occupational exposure limits not established for Ornidazole; minimize exposure using good industrial hygiene
Engineering Controls: Local exhaust ventilation or process enclosure, safety shower and eyewash facilities should be available
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), safety goggles, impervious protective clothing, dust-proof respirators if airborne dust presents a hazard
Environmental Exposure Controls: Avoid release to the environment; follow best practices for containment
Specific Monitoring: Monitor workplace atmosphere for dust concentrations if necessary

9. Physical and Chemical Properties

Appearance: White to pale yellow crystalline powder
Odor: Odorless or faint characteristic odor
pH: 6.5–7.5 (1% aqueous solution)
Melting Point: 85–87°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable (decomposes)
Solubility: Slightly soluble in water, soluble in ethanol and methanol
Density: About 1.42 g/cm³
Partition Coefficient (Log Pow): 0.43
Vapor Pressure: Negligible at room temperature
Viscosity: Not applicable (solid)

10. Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions, sensitive to light and moisture over time
Possibility of Hazardous Reactions: May react with strong oxidizers, acids, or alkalis
Conditions to Avoid: Direct sunlight, excessive heat, contact with incompatible chemicals, high humidity environments
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, hydrogen chloride, other hazardous gases under fire conditions

11. Toxicological Information

Acute Toxicity (Oral): LD50 (Rat) approximately 1450 mg/kg
Acute Toxicity (Dermal): Data not available
Acute Toxicity (Inhalation): No reliable data
Skin Corrosion/Irritation: Causes skin irritation in exposed individuals
Serious Eye Damage/Irritation: Causes significant eye irritation
Respiratory or Skin Sensitization: May cause respiratory irritation
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: In vivo and in vitro tests indicate potential for mutagenicity
Reproductive Toxicity: No specific reproductive effects reported in humans; animal studies not conclusive
Other Effects: Prolonged exposure can affect the central nervous system causing dizziness, headache, or gastrointestinal distress

12. Ecological Information

Ecotoxicity: Harmful to aquatic organisms at high concentrations, low potential for bioaccumulation
Persistence and Degradability: Not readily biodegradable, persistence shown in some water and soil environments
Mobility in Soil: Moderate mobility based on solubility and partition coefficient
Bioaccumulative Potential: Low based on Log Pow
Other Adverse Effects: May disrupt microbial activity in sewage treatment facilities at high concentrations, avoid discharge to the environment

13. Disposal Considerations

Waste Treatment Methods: Dispose of product and contaminated packaging according to local, regional, and national regulations
Incineration: Suitable method with approved waste disposal facility
Do Not: Release into drains, surface water, or ground soil
Contaminated Packaging: Waste packaging should be recycled or disposed of after complete decontamination

14. Transport Information

UN Number: Not classified as dangerous for transport
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Proper Shipping Name: Ornidazole
Environmental Hazards: Not considered environmentally hazardous for transport purposes
Special Precautions: Avoid dust generation and moisture during handling and shipping

15. Regulatory Information

TSCA (Toxic Substances Control Act): Listed
EINECS (European): Listed (240-744-6)
Canada DSL/NDSL: Listed on NDSL
EU Classification: Regulated under CLP Regulation (EC) No 1272/2008
Other Regulations: Subject to local, state, and national chemical safety and worker protection legislation
Labelling Requirements: Product labels must include hazard pictograms, signal word, hazard statements, and relevant precautionary information