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Product Name: Octanoyl Chloride
Chemical Formula: C8H15ClO
Synonyms: Capryloyl Chloride
CAS Number: 111-64-8
Recommended Use: Intermediate for organic synthesis, primarily in pharmaceutical and specialty chemical manufacturing
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GHS Classification: Flammable Liquids (Category 3), Skin Corrosion (Category 1B), Acute Toxicity Oral (Category 3), Specific Target Organ Toxicity Single Exposure (Category 3)
Signal Word: Danger
Hazard Statements: Causes severe skin burns and serious eye damage, toxic if swallowed, toxic if inhaled, may cause respiratory irritation, flammable liquid and vapor
Pictograms: Corrosion, Skull and Crossbones, Exclamation Mark, Flame
Precautionary Statements: Avoid breathing vapors, use only outdoors or in a well-ventilated area, wear protective gloves and eye protection, keep away from heat and sparks, wash skin thoroughly after handling
Routes of Exposure: Eyes, skin, inhalation, ingestion
Chemical Name: Octanoyl Chloride
Concentration: 98% and higher
Impurities: Trace amounts of HCl from hydrolysis, trace organic impurities related to the synthesis pathway, lesser amounts of other fatty acid chlorides
Molecular Weight: 162.66 g/mol
Inhalation: Move person to fresh air, keep at rest in a position comfortable for breathing, seek medical attention, provide oxygen if breathing becomes difficult, do not administer mouth-to-mouth resuscitation unless properly protected
Skin Contact: Remove contaminated clothing immediately, rinse affected skin with copious amounts of water for at least 15 minutes, seek medical attention for burns or persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing for at least 15 minutes, seek urgent medical care as burns and blindness can occur
Ingestion: Rinse mouth with water (do not swallow), seek immediate medical help, do not induce vomiting unless directed by medical personnel, observe for symptoms like difficulty in swallowing or irritation
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, alcohol-resistant foam; avoid water jet as violent reaction with moisture releases corrosive gases
Hazardous Combustion Products: Hydrogen chloride, phosgene, carbon oxides
Specific Hazards: Vapors are heavier than air and may travel to sources of ignition, fire may produce toxic or irritating fumes, material decomposes in presence of fire or high heat
Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective gear, chemical-resistant suit
Special Fire Fighting Procedures: Approach from upwind, contain and cool fire-exposed containers with water spray from a safe distance, avoid inhaling combustion gases
Personal Precautions: Evacuate unnecessary personnel, wear chemical splash goggles, rubber gloves, suitable respiratory protection, and impervious clothing, avoid breathing vapors, ensure adequate ventilation
Environmental Precautions: Prevent material from entering sewers, groundwater or surface water, notify local authorities in case of large spills
Cleanup Methods: Absorb spillage using inert absorbent like sand or vermiculite, collect for disposal in suitable closed container, neutralize residue with dilute sodium bicarbonate solution, ventilate area, wash residue to drain with excess water only when authorized
Precautions for Safe Handling: Handle in a designated chemical fume hood, avoid all direct contact, do not breathe fumes, use non-sparking tools and explosion-proof equipment, avoid contact with incompatible materials such as water, alcohols, strong bases and amines
Storage Conditions: Store in tightly closed bottles in a cool, dry, well-ventilated area, keep away from heat, sparks, open flames, and strong oxidizers, protect containers from physical damage, segregate from acids, bases, and moisture
Incompatibilities: Water, alcohols, amines, strong alkalis, strong oxidizers, strong bases, cyanides
Storage Life: Use within recommended shelf-life to avoid decomposition
Occupational Exposure Limits: No OSHA PELs or ACGIH TLVs set for Octanoyl Chloride, control exposure to the lowest levels reasonable
Engineering Controls: Work under a chemical fume hood, use local exhaust to capture vapors, keep eyewash stations and emergency showers nearby
Personal Protective Equipment: Chemical-resistant gloves (nitrile or butyl rubber), splash-proof goggles, full face shield, flame-resistant laboratory coat, rubber apron, respiratory protection (NIOSH-certified respirator for organic vapors if ventilation is inadequate), closed shoes
Hygiene Measures: Wash hands and face thoroughly after handling, do not eat, drink or smoke in working area, remove contaminated clothing before leaving work area, decontaminate surfaces and clothing before reuse
Appearance: Colorless to pale yellow liquid
Odor: Sharp, pungent, acid-like
Boiling Point: 191–193 °C at 760 mmHg
Melting Point: -15 °C
Flash Point: 71 °C (closed cup)
Vapor Pressure: 0.7 mmHg at 25 °C
Solubility: Reacts violently with water, soluble in organic solvents
Density: 0.95–0.98 g/cm³ at 20 °C
pH: Decomposes in water to form HCl
Partition Coefficient (log Kow): 3.3 (estimated)
Chemical Stability: Stable under standard, dry, and cool storage conditions
Reactivity: Strongly reacts with water and alcohols, producing corrosive and toxic gases
Hazardous Polymerization: Does not occur under recommended storage
Conditions to Avoid: Humid environment, exposure to moisture, heat, open flames, acids, and bases
Decomposition Products: Hydrogen chloride gas, phosgene, carbon oxides
Incompatible Materials: Water, strong bases, alcohols, amines, potassium, sodium, oxidizers
Acute Toxicity: LD50 Oral (rat): 400 mg/kg, causes rapid onset of symptoms; LD50 Dermal (rabbit): estimate over 1,000 mg/kg, based on structurally-related compounds
Routes of Entry: Inhalation, skin absorption, eye contact, ingestion
Symptoms of Exposure: Severe burns to skin and eyes, burning sensation, cough, wheezing, shortness of breath, headache, dizziness, abdominal pain, vomiting, and possible collapse at high concentrations
Chronic Effects: Prolonged exposure can lead to dermatitis, eye damage, respiratory system injury, no current evidence linking to cancer in humans
Sensitization: Not classified as sensitizer, but repeated skin contact increases risk of reactions
Mutagenicity, Carcinogenicity: Not listed as a confirmed carcinogen or mutagen by IARC, NTP, or OSHA
Ecotoxicity: Harmful to aquatic life due to rapid hydrolysis into octanoic acid and hydrochloric acid, both toxic at high concentrations
Persistence and Degradability: Hydrolyzes rapidly in presence of water, forming substances that can acidify aquatic environments; octanoic acid is biodegradable by natural bacteria
Bioaccumulation Potential: Low potential for bioaccumulation as octanoic acid further degrades
Mobility in Soil: High volatility and water reactivity reduces mobility; residues may persist if released in dry soil
Other Adverse Effects: Large spills threaten aquatic and terrestrial organisms due to acidity
Waste Treatment Methods: Small quantities can be neutralized with care by slowly adding to excess water mixed with dilute base while stirring and cooling; always in a working fume hood
Disposal Containers: Use compatible, tightly sealed, clearly labeled hazardous waste containers
Precautionary Disposal: Do not dispose down drain or in municipal waste; incineration in licensed chemical waste facility is preferred option
Unused Material: Contact licensed waste disposal service for safe removal
UN Number: UN 3265
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (contains Octanoyl Chloride)
Transport Hazard Class: 8 (Corrosive), Subsidiary Risk: 3 (Flammable liquid)
Packing Group: II
Labels Required: Corrosive, Flammable
Environmental Hazards: Dangerous to aquatic environments; marine pollutant
Special Precautions: Avoid shipment with incompatible chemicals, secure upright positioning, follow local, state, federal transport regulations
OSHA: Covered under Hazard Communication Standard, hazardous chemical listing
TSCA Inventory Status: Listed
EPCRA Section 302/304 Extremely Hazardous Substances: Not listed
SARA 311/312 Hazards: Immediate (acute), fire hazard
SARA 313: Not subject to reporting
California Proposition 65: Not listed as a carcinogen or reproductive toxicant
Other Regulations: Check specific local, national, or regional environmental regulations for workplace storage, handling, and emissions
