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Chemical Name: Octadecyl Isocyanate
Synonyms: n-Octadecyl isocyanate, Stearyl isocyanate
CAS Number: 4306-88-1
Molecular Formula: C19H37NO
Use: Used in organic synthesis, surface treatment, polymer chemistry
Manufacturer Information: Manufacturer’s address and contact number must be checked from distributor
Emergency Phone: Refer to local emergency center or CHEMTREC
Hazard Class: Toxic by inhalation, skin contact, and ingestion
Hazard Code: Acute Toxicity, Skin and Eye Irritation, Respiratory Sensitization
Signal Word: Danger
Hazard Statements: Harmful if inhaled, causes severe skin burns and eye damage, may cause allergic respiratory reaction, can cause organ damage through prolonged exposure
Pictograms: Corrosive, Health Hazard
Precautionary Statements: Avoid breathing vapors/mist, wear protective equipment, wash skin thoroughly after handling, prevent release to environment, use outdoors or in well-ventilated places
Component: Octadecyl isocyanate
CAS Number: 4306-88-1
Purity: >95%
Impurities: Unreacted fatty acid, minor isocyanate derivatives
Other Ingredients: No significant non-hazardous impurities reported
Inhalation: Remove person to fresh air, keep at rest, get medical advice if respiratory symptoms persist
Skin Contact: Remove contaminated clothing immediately, rinse skin with plenty of water for at least 15 minutes, obtain medical attention
Eye Contact: Rinse thoroughly with water for at least 15 minutes, lifting eyelids occasionally, seek medical attention promptly
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical help immediately
Most Important Symptoms/Effects: Burning sensation, coughing, shortness of breath, severe skin and eye irritation, potential allergic reaction
Notes for Physician: Treat symptomatically, consider respiratory sensitization, monitor for delayed symptoms
Suitable Extinguishing Media: Use dry chemical, foam, or carbon dioxide (CO2), water spray only for cooling containers
Hazardous Combustion Products: Releases toxic gases including carbon oxides, nitrogen oxides, hydrogen cyanide
Firefighting Precautions: Wear self-contained breathing apparatus and protective clothing, avoid inhalation of fumes, evacuate area if necessary
Special Methods: Use water spray to cool unopened containers, avoid using water directly on burning material, build containment to prevent runoff
Flammability: May burn but not readily ignitable, keep away from sources of ignition
Personal Precautions: Evacuate unnecessary personnel, ventilate area, wear chemical splash goggles, gloves, protective suit, and respirator
Environmental Precautions: Prevent entry into sewers, groundwater, and surface water, prevent spillage from entering drains
Spill Cleanup Methods: Absorb with inert material (sand, earth), collect spillage in labeled containers for disposal, clean contaminated area thoroughly, wash site after material pickup
Emergency Procedures: Notify emergency services if exposure risk exists, restrict area until cleanup is complete
Handling: Avoid breathing vapors or dust, keep away from open flames and hot surfaces, use only with adequate ventilation, avoid all contact with skin and eyes, do not eat or drink while using
Storage: Store in cool, dry, well-ventilated location away from moisture, acids, bases, and incompatible materials, keep container tightly closed, keep away from food, do not store together with oxidizing substances
Special Precautions: Store only in original container, label all storage containers clearly, maintain access to eyewash and safety showers in working area
Occupational Exposure Limits: No OSHA PEL or ACGIH TLV specifically assigned, minimize exposure, workplace air concentration should be kept as low as possible
Engineering Controls: Use only in chemical fume hood or with local exhaust ventilation, maintain negative air pressure in storage areas
Personal Protection: Wear impervious gloves (nitrile or neoprene), chemical safety goggles, face shield, lab coat or chemically resistant apron, closed footwear
Respiratory Protection: NIOSH-approved air-purifying respirator if ventilation is inadequate
Hygiene Measures: Wash hands and face thoroughly after handling, remove and wash contaminated clothing before reuse
Appearance: White to off-white crystalline solid or waxy solid
Odor: Characteristic, acrid as isocyanates
Odor Threshold: Not available
pH: Not relevant (reacts with water)
Melting Point: 34-37 °C
Boiling Point: Not clearly defined, decomposes before boiling
Flash Point: Estimated above 110 °C
Evaporation Rate: Not established
Vapor Pressure: Very low at room temperature
Solubility: Insoluble in water, reacts slowly with water, soluble in organic solvents like toluene, THF
Partition Coefficient: logP (octanol/water) expected high, not measured
Decomposition Temperature: Decomposes at high temperature releasing toxic fumes
Viscosity: Not applicable
Stability: Stable in sealed container under recommended storage, decomposes on heating
Reactivity: Reacts with water, alcohols, amines, acids; reacts to form ureas and carbon dioxide
Conditions to Avoid: Moisture, humidity, elevated temperature, sources of ignition
Incompatible Materials: Strong acids, bases, oxidizers, and water
Hazardous Decomposition: Carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen cyanide, hydrocarbons
Polymerization: May occur if combined with water or warm temperatures, exothermic
Likely Exposure Routes: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Harmful by inhalation, ingestion, or skin absorption; specific LD50 data for Octadecyl isocyanate not widely available, related isocyanates show moderate toxicity
Skin Corrosion/Irritation: Causes burns, redness, swelling, blistering anticipated
Eye Damage/Irritation: Causes serious damage, severe pain, potential for vision loss
Respiratory Sensitization: May cause allergic-type asthma, cough, difficulty in breathing
Chronic Effects: Prolonged or repeated exposure may sensitize respiratory system and skin, risk of permanent lung/skin damage
Carcinogenicity: No data for Octadecyl isocyanate, other isocyanates are not classed as carcinogens
Mutagenicity: No specific data found
Reproductive Toxicity: Not established for this compound
Aquatic Toxicity: Expected to be toxic to aquatic organisms due to reactivity, very low water solubility limits acute exposure
Persistence and Degradability: Likely to hydrolyze slowly in water, forms stable residues in soil, not readily biodegradable
Bioaccumulation Potential: High logP suggests possible bioaccumulation in aquatic organisms
Mobility in Soil: Low mobility expected, binds strongly with organic material
Other Adverse Effects: May react with water to release hazardous products, monitor for contamination especially near drainage
Waste Treatment Methods: Dispose of contents and container through licensed hazardous waste facility
Product Disposal: Do not mix with non-compatible waste streams, neutralize residual material with dilute acid or alcohol under fume hood before disposal if possible
Contaminated Packaging: Rinse thoroughly with suitable solvent, treat rinse liquid as hazardous, fully triple rinse containers before recycling or disposal
Legal Requirements: Follow all local, regional, and national environmental regulations, obtain proper permits if required
UN Number: 2206 (Isocyanates, nos.)
Proper Shipping Name: Isocyanates, solid, toxic, nos.
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II or III depending on concentration
Environmental Hazards: Not classed as marine pollutant but spill has hazardous environmental impact
Special Transport Precautions: Keep separate from foodstuffs, keep containers upright, secure load, label clearly according to regulations, avoid temperature extremes
Safety, Health, and Environmental Regulations: Subject to OSHA Hazard Communication Standard, included on TSCA Inventory, follow REACH Annex XVII for isocyanates in the EU, SARA Title III reporting for toxic chemical release may apply
Labeling Requirements: GHS/CLP (pictograms, hazard and precautionary statements required)
Additional National/Regional Requirements: Refer to country-specific chemical safety and reporting laws, some jurisdictions require chemical user registration and compliance audits
