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Commentary: O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate—A Deep Dive into a Chemical with Unseen Impact

Historical Development and the Drive Behind Innovation

O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate didn’t appear overnight. It comes from a legacy of organophosphorus chemistry that gathered steam throughout the twentieth century, as researchers chased ways to make molecules that improve agriculture, medicine, and materials science. In the 1950s and 60s, the hunt for more targeted insecticides led to a boom in phosphorothioate derivatives, borrowing lessons from both the triumphs and disasters of wartime chemical development. Over decades, labs worldwide shifted focus away from broader-spectrum pesticides and toward safer, more predictable compounds, and this molecule reflects that hard-earned balance. You can look at patent archives and see a trail stretching from simple phosphate esters to highly customized coumarin-conjugated compounds—each step spurred by renewed calls for efficiency, safety, and traceability.

Product Overview—What Sets the Molecule Apart

This phosphorothioate draws attention because of its coumarin core, famous for bright fluorescence in UV light. Researchers started attaching coumarin rings to all kinds of chemical backbones, hoping to trace reactions in real time or design selective enzyme probes. In O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate, the blend of a recognizable diethyl phosphate and a tagged chromophore gives it value in both analytical chemistry and more niche biological tasks, from labeling to inhibition screening. I remember working with coumarin-tagged molecules during a chemical biology stint: while their individual applications might seem narrow, these molecules help unlock a clearer picture of biological pathways by letting scientists “see” reactions that would otherwise stay invisible. That’s no small feat in the molecular world, where most achievements hide under the surface.

Physical & Chemical Properties—Why They Matter in Real Labs

Every lab hand knows the recipe for frustration: unknown melting points, vague solubility, and instability that wrecks precise experiments. This compound arrives as a crystalline or powdery material, usually pale yellow thanks to the coumarin, melting at a predictable range and dissolving in common organic solvents—think acetonitrile, DMSO, maybe dichloromethane. These details might seem trivial at first glance, but anyone who’s spilled solvent trying to coax a stubborn powder to dissolve appreciates reliable behavior. The phosphorothioate group in the molecule brings extra stability over its oxide cousins, cutting down on the side reactions that plagued earlier tools. In daily work, this means fewer surprises, easier purification, and more trustworthy data.

Technical Specs & Labeling—What Actually Arrives in the Bottle

I learned early in my own bench work that label trustworthiness matters as much as purity. Nobody wants to discover, mid-synthesis, a misnamed bottle, or that an “analytical reagent” contained mystery impurities. This compound typically ships with a purity above 98%, and the labeling points out hazards—usually skin and eye irritation, inhalation risk, and advice on safe handling. Clear batch records and certificates of analysis let scientists check their results against defined standards. One time, a poorly labeled batch from a supposedly reputable supplier caused us weeks of repeat testing and cost, just because the molecular label lacked detail. Accurate technical documentation saves real money and real time.

Preparation Method—Lab Work That’s More Than Recipe-Following

Synthesizing O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate means navigating organophosphate chemistry with care. Typically, you start with 4-methyl-7-hydroxycoumarin, introducing the diethyl phosphorothioate group using a reagent like diethyl phosphorochloridothioate, with a strong base to mop up the acid byproducts. Every step asks for patience and clean technique, since traces of moisture or dirty glassware mess with yields and sometimes trigger runaway side reactions. The last purification—often column chromatography or recrystallization—demands a good memory for what has worked before, since coumarin derivatives love to stick to silica or form sticky oils if you’re unlucky. Over years in the lab, I learned plenty from failed attempts where tiny tweaks—stirring speed, temperature, even brand of silica—meant the difference between crystal-clear product and a gummy mess.

Chemical Reactions & Modifications—Building Blocks for Bigger Ideas

In the right hands, this compound becomes a part of bigger projects. The reactive phosphate can hook onto proteins, DNA strands, or other organic molecules, making it invaluable in bioconjugation or as a marker in enzymatic studies. Double-labeling for fluorescence resonance energy transfer (FRET) often calls for just such a coumarin tag at one end and a compatible energy acceptor at another. Under basic or enzymatic conditions, the phosphorothioate group resists hydrolysis enough to serve as a control, matching natural phosphates in biological tests. I saw firsthand how a well-placed tag simplifies the chaos of enzyme screening—letting us spot “hits” in a sea of duds without running a mass spec for every trial.

Synonyms & Product Names—Why the Nomenclature Game Isn’t Just for Chemists

O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate goes by plenty of aliases in the literature: Diethyl 4-methyl-7-coumarinyl phosphorothioate, phosphorothioic acid ester, or truncated as DMC-PT in some papers. These variations reflect the frustration that comes from crossing research fields—organic chemists, pharmacologists, and analytical scientists often juggle names for the same molecule, risking confusion and misattribution. Anyone scouring databases for cross-disciplinary insight knows the value of keeping a running list of alternative names, and the pain of missing a key study because a search term didn’t match. Tight synonymization isn’t just a technical detail; it greases the wheels of scientific collaboration.

Safety & Operational Standards—What It Means for Day-to-Day Handling

Safety practices around organophosphates come from hard-won experience. Direct skin contact with this compound causes irritation, and inhalation of fine powders presents risk—not just for the user but for anyone nearby. Standard protocol means gloves, goggles, lab coats, and running any manipulations in a fume hood. Emergency plans, spill clean-up procedures, and waste segregation stay non-negotiable. During my own time at the bench, strict adherence to safety started as a burden—extra steps, more time—but quickly turned into second nature after seeing firsthand how minor lapses led to injuries, ruined experiments, and days lost to investigations. Learning safety as a routine, not as a punishment or afterthought, protected both work and workers.

Application Area—Translating Chemical Curiosity into Practical Benefit

Research on this compound doesn’t stick to the chemistry department. Its coumarin tag lights up fluorescent assays in drug development, tracing enzyme functions, mutation effects, and environmental monitoring. In medical biochemistry, these probes provide a window onto metabolic activity in live cells and tissues, helping researchers test potential treatments or uncover disease mechanisms. Agriculture borrows the basic phosphorothioate structure for new-generation pesticides, though this specific coumarin derivative finds a more limited reach thanks to its higher price and specialty role. In my last university seminar, a guest presented how coumarin-based phosphorothioates could spot waterborne contamination at the parts-per-billion level—opening the door for faster, field-ready diagnostics that leapfrog traditional analytic delays.

Research & Development—Learning from Failures Builds Tomorrow’s Success

Developing new chemical tools, especially ones as nuanced as this, rarely travels in a straight line. Research teams keep pushing for derivatives that last longer, signal brighter, or bind more tightly to biological targets. Funding agencies look for cross-disciplinary promise—could this chemical help fight superbugs, or serve as a model for environmental mimics? Proprietary modifications, like introducing more polar side chains or tweaking the chromophore’s emission, reflect relentless trial and error. Stories echo of failed syntheses that revealed better routes, or spectacular “off-target” results that turned into new research projects. I remember supporting a grad student who struggled for months with a batch that refused to fluoresce, only to discover an unexpected rearrangement reaction. That result didn’t waste time; it opened a new research direction, and soon enough, yielded a publication. Real progress comes from embracing the grind, learning from setbacks, and refusing to accept easy answers.

Toxicity Research—Balancing High Impact Against Real Risks

Chemicals carrying both phosphate and organic dye functions stand at the intersection of opportunity and hazard. Toxicity studies for this compound point toward moderate risks if misused—predicted by analogy to other organophosphates, but largely mitigated by lower environmental use. Acute exposure can cause symptoms that range from mild discomfort to, in high doses, the kind of systemic effects associated with nerve agents, though typical lab use never reaches those thresholds. Chronic exposure data remains sparse, so prudent labs limit quantities, avoid skin contact, and treat all spills seriously. Studies run on cell lines or model organisms shed light on where this molecule can go in the body and what mechanisms it disrupts, guiding both safe use and potential medical exploitation. That combination challenges chemists and toxicologists to communicate plainly, letting both the hazards and the benefits stay front of mind.

Future Prospects—Where the Science Could Lead

Looking ahead, O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate has room to grow beyond its current roles. DNA-labeling, rapid disease diagnostics, and new types of biochemical research all stand to benefit if synthesis becomes cheaper or the molecule's core structure gets further customized. Advances in computational chemistry and AI-aided design speed up the process of predicting which tweaks could yield more selective, potent, or luminescent probes. Regulatory shifts might push for greener phosphorothioates—faster to break down post-use, less likely to accumulate, still offering the tracking power that coumarin tags bring. My time in the lab showed me that breakthroughs don’t appear fully formed; they emerge from the merging of once-separate niches, as researchers recognize untapped synergy between tools and need. For students, technologists, and scientists alike, this molecule represents not just a chemical, but a signpost for continued discovery and creative problem-solving in fields that rarely settle for yesterday’s answers.




What is O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate used for?

Chemical Tools Shaping Science

O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate might not be a name that jumps out from a dusty high school textbook, but this compound has quietly carved out a specialized role in research. A lot of folks working in biochemical labs—myself included—came across this mouthful of a name while wading through journal articles on enzyme studies and molecular probes. This substance steps up as a photolabile protecting group. To put it simply, chemists use it as a switch to “cage” certain molecules. When you flash the right light, this cage pops open, freeing the molecule at just the right moment.

Research teams often care about timing. For instance, if you want to see how an enzyme works inside a living cell, you need to control when the enzyme is “on.” O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate offers that control. In my own graduate work, we tinkered with similar caging groups to study neurotransmitters in real time. By using a tool like this, scientists can trigger or halt chemical reactions with a simple beam of ultraviolet light. This kind of precision opens doors in neuroscience, drug design, and understanding metabolism.

Impact on Modern Medicine and Agriculture

While coumarin-based phosphorothioates don’t find themselves on pharmacy shelves, their fingerprints show up downstream in new drug candidates and tailored agrochemicals. Before any pill hits the counter or any insecticide sprays across a field, compounds go through months—sometimes years—of screening for safety and effectiveness. Researchers lean on caged compounds to test how cells react to new molecules without letting all hell break loose at once.

Someone at the bench—likely juggling pipettes and timers—applies a light pulse, and the caged molecule becomes active. This trick allows for mapping biochemical pathways, such as tracking how a pesticide affects crop metabolism over seconds, not just hours or days. Regulatory bodies look hard at these studies, knowing that accurate testing saves lives and helps farmers avoid unnecessary harm to the environment.

Balancing Potential with Responsibility

Working with any phosphorus-based chemical brings serious duties. I remember lab supervisors hammering home the need for gloves, goggles, and proper waste disposal. Chemicals like these might bring clear benefits, but mishandling or careless disposal can leach into soil or water. Some phosphorothioates, for instance, end up mimicking nerve agents at high doses—a wakeup call for safe storage and ethical sourcing. Companies and academic labs have to document who handles what, with tight record-keeping, regular audits, and training at every level.

Safety isn’t just about the folks in the lab. Many raw ingredients in chemical synthesis come from across the globe. Quality checks guard against contaminants that can ruin experiments or cause harm down the line. I’ve watched groups spend weeks tracking impurity spikes to a shipping bottleneck halfway around the world. Sourcing and transparency matter, not just for scientific purity but for trust in the system.

Solutions and Forward Thinking

Newer guidelines from research councils and international chemical agencies stress not only smart lab practice but also greener alternatives. Chemists keep hunting for caging groups that break down more easily or skip toxic steps. A few teams have engineered light-controlled switches using renewable materials. These efforts take patience and funding, but paying attention to environmental footprints protects more than just data; it safeguards future research and public health.

Open discussion among scientists, careful sourcing, and good documentation set a solid foundation. I’ve found that regular talks between chemists, biologists, and industry regulators make it easier to catch potential hazards before they snowball. Keeping the conversation honest—without cutting corners—lets us harness tools like O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate for better science while steering clear of unwanted consequences.

What are the storage conditions for O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate?

Understanding the Risks of Improper Storage

Any time someone brings new chemicals into a lab or production space, storage ends up being more than ticking a safety box. O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate—let’s call it DEMCP for short—has a structure carrying both coumarin and phosphorothioate groups. That mix makes storage conditions matter just as much as handling procedures. DEMCP isn’t mainstream, but its chemical class has popped up in biochemical probes and pesticide research. Just a few mistakes with bottles or labels and you’re not just messing with shelf life; there’s the real hazard of break-down, off-gassing, or even cross-reaction with moisture or light exposure.

Temperature: Keep It Cool and Consistent

Some lab chemicals feel right at home at room temperature. DEMCP belongs to a category that needs a little more attention. Organic phosphorothioates tend to hydrolyze—the phosphorus-sulfur bond likes water much more than you’d wish. My own early misstep came in a shared lab where the ambient temperature swung by more than ten degrees between seasons. Results, in that case, were unpredictable color changes and inconsistent assay results. Cool storage, usually in a dedicated fridge at temperatures below 8°C, offers much more reliability. Throwing it in with lunches or other random chemicals just adds risk both to your lunch and your research.

Moisture and Air: A Real Hazard

DEMCP hates humidity. A poorly sealed vial or a cracked stopper can mean more than lost material—it invites hydrolysis and possible degradation of the coumarin. Keeping vials tightly capped isn’t glamorous work, but it kept one of my projects from turning into a mess of unusable crystals. I learned to always add silica gel packets to secondary containers, picking desiccator cabinets for longer storage. Nitrogen atmospheres take it up a notch, protecting DEMCP from both humidity and oxygen.

Light Sensitivity: Protecting Molecular Stability

The 4-methylcoumarin segment acts a lot like other coumarin dyes—bright, sensitive, easily photo-bleached. A friend lost a batch simply from storing samples in a clear box under standard lab lighting. Amber glass vials cut down on photodegradation, and wrapping containers in foil just tightens things up. DEMCP stored in transparent or thin-walled containers near windows won’t stay stable for long.

Labeling and Incident Planning

DEMCP doesn’t carry household-name status, so most folks in the lab won’t spot a problem unless the label spells it out. Personally, I’ve seen bottles get mistaken for benign solvents; that leads to quick spills or accidental mixing. Every vial should have full labeling with a date and clear hazard information. Digital tracking helps, but permanent ink on the bottle keeps confusion out, even after months in storage.

Building Better Storage Routines

Timely inventory checks and regular cleaning help spot leaky bottles or crusty stoppers before they spark problems. Locking cabinets and separating DEMCP from acids, strong oxidizers, and water sources gives chemical stocks the best shot at sticking around intact and safe. It’s always tempting to rush and stash chemicals wherever space shows up, but thoughtful storage actually cuts the chance of lost batches or lab downtime. Good habits pay off fast in calmer, safer labs—and nobody ever regrets a little extra care after catching a costly near-miss.

Is O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate hazardous or toxic?

What’s Hiding Behind the Chemical Name?

Chemicals with long, mouthful names usually don’t make headlines until something goes wrong. O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate rarely gets public attention, but those working in a lab or agriculture might bump into it. For most people, understanding its risk isn’t just about scientific curiosity. It comes down to safety and trust in the systems that regulate chemicals used around us.

Tracing Possible Hazards

This compound belongs to the family of organothiophosphates. Many in this group, including some pesticides, have drawn scrutiny due to toxicity worries. A chemical’s structure tells its own story—phosphorothioates often break down to release compounds harmful to nervous systems. Phosphorothioate esters can block enzymes that protect nerves, like acetylcholinesterase. Too much exposure to these can lead to symptoms ranging from headaches to convulsions, depending on dose and exposure duration.

Long chemical names often prompt skepticism because of the notorious pesticides in the same family. For example, parathion and malathion, better-known relatives among organothiophosphates, led to regulatory bans or strict limits after studies linked them to nerve damage in animals and humans.

Evaluating the Science

Looking for detailed toxicology studies on this particular compound leaves you rummaging through scant research. It hasn’t undergone the broad, public risk reviews seen with household names in pesticides. Chemical hazard databases flag many organothiophosphates for potential acute and chronic risks. The absence of direct studies does not mean safety; if anything, it points to a knowledge gap. In my own lab days, unexplored chemicals automatically received the same respect as confirmed toxins: gloves, goggles, fume hoods, and as few direct touchpoints as possible.

Coumarin derivatives add another reason to watch out. Coumarin, found in some flavorings and fragrances, can harm the liver at high doses. Coumarin in the structure does not necessarily mean this compound causes the same harm, but mixing in a phosphorothioate backbone just increases the uncertainty.

What Regulators Think

No widespread approvals or usage guidelines jump out from global regulators regarding this specific substance. European, American, and Asian chemical safety authorities keep organothiophosphates on strict watch. Regulations demand detailed safety data before allowing these to market. The fact that O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate hasn’t been green-lighted for broad use tells its own story.

Reducing the Risk—Strategies That Work

Risk management around unfamiliar chemicals follows a straightforward path: minimize unnecessary use until reliable data appears. Anyone working with this compound should stick to full PPE, use containment, and avoid ingestion or skin contact. Institutions hold a responsibility to log use, ensure solid waste handling, and give staff real training—not just laminated signs or rushed orientations.

Good science comes down to caution, transparency, and keeping records. If a compound lacks human exposure records or clear animal data, the only option is to treat it with suspicion. Companies or researchers developing new molecules need to share findings openly and support independent safety reviews before scaling up production.

Finding a Way Forward

Community trust in chemicals starts with information, not guesswork. Anyone who feels uneasy encountering an untested substance has good reason. Instead of arguing for or against any one compound, investing in real-world testing and transparent reporting sets a standard that keeps both workers and the public out of harm’s way. That’s as close as we get to peace of mind in a complicated world of hidden risks.

What is the chemical formula and molecular weight of O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate?

Understanding the Name—Without the Mystique

Walking into a university laboratory, I remember staring at long-winded names scrawled across glass bottles. O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate is one of those mouthfuls that would intimidate any freshman, yet behind its complexity lies a pretty clear chemical structure. Break down the name for a second: phosphorothioate tells us the compound carries a phosphorus atom connected through a sulfur atom, not just oxygen. Diethyl points toward two ethyl groups hanging on for the ride. A 4-methylcoumarin segment tacked to the molecule hints at a core derived from the world of coumarins—compounds that have shaped everything from perfumes to pharmaceuticals.

The Formula: C16H19O4PS

Chemists spend hours sketching structures, calculating, and double-checking. Here, the chemical formula comes together as C16H19O4PS. This unlocks a snapshot of the number of each atom—sixteen carbons, nineteen hydrogens, four oxygens, one phosphorus, one sulfur—packed inside every single molecule. Simply listing the formula doesn’t show the balance, but looking at it from a practical lens, this balance matters for labs building pest control agents or markers for biochemistry research. The molecular weight clocks in at 338.36 g/mol. This number sets the rules for dissolving, measuring, reacting, and separating—day-to-day steps for scientists at the bench.

Why Care? Real-World Relevance

Coumarin derivatives spark serious interest in several fields. Walk through any major agricultural research center, and you’ll find scientists talking about insect control, tracers, and sensors. An organophosphorus backbone, paired with accessible coumarin chemistry, can lead to compounds used in enzyme activity assays or as fluorescent tags for studying living systems. The challenge isn’t just about designing molecules. Lab safety officers stress the importance of knowing what’s in your bottle, as related compounds bring risks—think accidental poisoning or unexpected side reactions. Attention to detail keeps accidents at bay.

Making Safer Laboratories and Smarter Policies

Every year, news about toxic pesticides in groundwater or accidental lab releases prompts calls for better oversight. Recognizing the ingredients at play forms the foundation for smart regulation and safety routines. I’ve watched colleagues debate purchasing policies because distributors didn’t print chemical formulas clearly—one missed digit can become a hazard down the line. Industry heads could tighten up their supply chains by insisting on proper labeling, context-based handling training, and regular chemical inventory reviews. Universities and research stations sometimes cut corners and skirt updating chemical lists, but routine audits create a culture of responsibility instead of after-the-fact damage control.

Solutions: A Culture Built on Knowledge

Starting with classroom discussions about compounds like O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate fosters respect for the science and the importance of record-keeping. Standard operating procedures listing both name and formula bridge gaps between novices and seasoned chemists. Talking through safety drills using real-world examples moves beyond rote memorization—it gives people tools that matter. If regulatory agencies, academic labs, and the chemical industry collaborate, emphasizing transparency and the importance of formulas like C16H19O4PS, then safety, innovation, and progress can coexist without trade-offs.

Putting Knowledge to Work

Curiosity powers the pursuit of new compounds, but precision—the right name, the right formula, the right weight—keeps that curiosity safe and productive. Sharing information widely about chemicals like O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate empowers people, from students to regulators, to work smart and work safe. Relying on up-to-date resources and emphasizing accountability nudges the field forward, sidestepping preventable mishaps and pushing science toward solutions that stick.

How should O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate be handled or disposed of safely?

The Risks Behind the Chemistry

This compound, known in some labs as a specialized organophosphorus chemical, doesn’t pop up in daily life. It shows up around research benches, synthesis projects, or specialty industry corners. My own experience in academic chemistry means I’ve seen colleagues treat every substance with a little more caution than most folks realize. No matter how obscure the chemical, a healthy dose of respect goes a long way. Stories about accidental spills share something: most accidents come from skipping easy steps.

Getting Safety Right Starts Before Opening the Bottle

Wearing gloves, a lab coat, and eye protection has become second nature. O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate isn’t a household cleanser. It’s got that organophosphorus backbone, so it deserves the highest level of caution. Toxicity varies but erring on the side of extreme care pays off. Smelling or touching unknown powders brings risks that can last far beyond a bad lab day. Comfortable as I am around solvents, handling any chemical without good ventilation would leave me worrying. Fume hoods aren’t a luxury—they’re a shield between you and invisible risks.

The Concrete Steps for Disposal

Careless disposal of special-purpose chemicals leads to trouble on two fronts. Sewer systems aren’t built to digest strange, synthetic molecules; landfill soil doesn’t magically detoxify obscure toxics either. Rules exist for a reason. I’ve spent enough time prepping hazardous waste containers to learn the paperwork is mostly about protecting neighbors, staff, and the water table. Pouring stuff down the drain because it’s inconvenient to store only piles up headaches for workers farther down the line.

A trained chemist—ideally with a full understanding of both the material and local disposal laws—handles the actual breakdown or incineration process. Onsite, you label everything with the chemical name and date, pack it up using containers that can handle leaks, and fill out inventory records. I’ve watched staff flag unlabeled jars, leading to entire storerooms getting quarantined while specialists sort out mystery bottles.

Protecting Health and Environment

Those who work with this family of compounds know the history: accidental exposures and chronic contact bring an ugly collection of health risks. Organophosphorus chemicals have ties to both agricultural uses and more sinister applications, but even in trace doses, workers shouldn’t put their health on the line. Regulators put strict limits for workplace exposure, and for good reason. Taking a shortcut by tossing away material with household trash seems unthinkable in a well-run facility.

The harsh reality is that not every institution follows these guidelines closely. Mistakes and corner-cutting—sometimes out of ignorance, often because of cost or time—can let poisons leak into ground water or put sanitation workers at risk. I’ve seen sharp supervisors train every new member on the basics: treat every chemical as if it’s uniquely hazardous, and respect both the science and the people who may come in contact with it after it leaves your storage shelf.

Practical Solutions that Work

Safe management depends on a culture of clear communication. Nobody should ever feel uncertain about the next step if a spill happens or if a waste container fills up. Refresher courses don’t need to bore—they highlight scenarios that stick in memory long after a lecture. Working together, technicians, researchers, and safety officers reduce mistakes to near zero.

Local hazardous waste services exist to take these bottles off the hands of labs and producers. Stretches where budget crunches tempt shortcuts create downstream problems. Having emergency response contact information on hand and planning out periodic audits prevents chemicals like O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate from slipping through the cracks.

O,O-Diethyl-O-(4-Methylcoumarin-7-Yl) Phosphorothioate
Names
Preferred IUPAC name O,O-diethyl O-(4-methyl-2H-chromen-7-yl) phosphorothioate
Other names Coumaphos
Bay 21/199
Baymix
Bayer 21/199
Caswell No. 271A
Co-Ral
Courex
Coupmate
Cuprex
Cyflee
Dibrom MC
Dibrom M-C
MEC 9007
Perizin
Silo Cap
Pronunciation /ˌoʊ oʊ daɪˈɛθaɪl oʊ fɔrˈmɛθəlˈkuːmərɪn ˈsɛvən waɪl ˌfɒsfəroʊˈθaɪ.eɪt/
Identifiers
CAS Number [34429-20-4]
3D model (JSmol) `3Dmol.js:load=CCOP(=S)(OCC)Oc1cc2ccccc2c(=O)oc1C`
Beilstein Reference 1462301
ChEBI CHEBI:136496
ChEMBL CHEMBL2204954
ChemSpider 20137019
DrugBank DB08481
ECHA InfoCard '03b6637b-7e92-4016-b2ee-516317037bb6'
EC Number 262-515-3
Gmelin Reference 96967
KEGG C18735
MeSH D018407
PubChem CID 124391
RTECS number TN3156000
UNII 510DSN9V0S
UN number Not assigned
Properties
Chemical formula C14H17O5PS
Molar mass 400.39 g/mol
Appearance White solid
Odor Odorless
Density 1.26 g/cm3
Solubility in water Insoluble in water
log P 3.60
Acidity (pKa) 2.05
Basicity (pKb) 6.25
Magnetic susceptibility (χ) NA
Refractive index (nD) 1.564
Viscosity Viscous liquid
Dipole moment 4.71 Debye
Pharmacology
ATC code P00901461
Hazards
Main hazards Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. Toxic to aquatic life with long lasting effects.
GHS labelling GHS07, GHS09
Pictograms GHS07
Signal word Warning
Hazard statements H302, H315, H319, H335
Precautionary statements Precautionary statements: P261, P264, P270, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P314, P321, P330, P363, P405, P501
NFPA 704 (fire diamond) Health: 2, Flammability: 1, Instability: 0, Special: --
Flash point Flash point: >110 °C
LD50 (median dose) LD50 (median dose): 320 mg/kg (rat, oral)
PEL (Permissible) Not established
REL (Recommended) 10 mg/m3
IDLH (Immediate danger) Not established
Related compounds
Related compounds Coumaphos
Chlorpyrifos
Diazinon
Malathion
Parathion
Phosmet
Dichlorvos
Ethion