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Product Name: O-Ethyl-O-(4-Nitrophenyl)Phenylthiophosphonate
Chemical Family: Thiophosphonate ester
Synonyms: EPN
Use: Chemical intermediate, pesticide
Manufacturer: Refer to purchase records for supplier details
Emergency Phone Number: Contact the national poison authority
Product Code: Document according to inventory management
CAS Number: 2104-64-5
UN Number: 2783 (Toxic, liquid, organic, n.o.s.)
Revision Date: Refer to date of receipt for this batch
Signal Word: Danger
Hazard Class: Acute toxicity (oral, dermal, inhalation), environmental hazard
Pictograms: Skull and crossbones, Environment
Hazards: Rapid absorption through skin, systemic poisoning, cholinesterase inhibitor, nerve agent-like effects, may cause death if swallowed or inhaled, toxicity to aquatic organisms
Precautionary Statements: Avoid breathing dust, vapor, or spray; do not get on skin or eyes; use suitable PPE
Exposure Routes: Skin, eyes, inhalation, ingestion
Symptoms: Headache, dizziness, sweating, nausea, muscle twitching, convulsions, respiratory failure
Target Organs: Nervous system, blood cholinesterase
Main Ingredient: O-Ethyl-O-(4-Nitrophenyl)Phenylthiophosphonate >15%
Impurities: Technical grade impurities <1% each
Other Constituents: Organic solvents (xylene or others), inert carriers as specified by the supplier
Mixture Type: Multi-component liquid or solid, check manufacturer COA
Concentration: Active ingredient >15% by weight
CAS Number: 2104-64-5 for O-Ethyl-O-(4-Nitrophenyl)Phenylthiophosphonate
Inhalation: Move person out of the contaminated area, keep at rest, maintain open airway, provide oxygen if breathing is difficult, seek immediate medical attention
Skin Contact: Remove contaminated clothing, flush skin with copious flowing water and soap, wash thoroughly for at least 15 minutes, seek urgent medical advice
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present, keep eyes open during rinsing, consult ophthalmologist immediately
Ingestion: Do not induce vomiting, rinse mouth, provide water to drink if conscious, get medical help without delay
Antidote: Atropine and pralidoxime recommended for cholinesterase inhibition, administered only by medical professionals
Special Notes: Immediate transport to medical facility, ensure rescuers use appropriate PPE
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water mist
Unsuitable Media: Direct water jet, risk of chemical runoff
Special Hazards: Toxic sulfur oxides, phosphorus oxides, nitrous gases released during combustion, runoff may cause environmental contamination
Protection for Firefighters: Full protective suit, self-contained breathing apparatus, positive pressure demand
Firefighting Advice: Isolate hazard area, keep out unprotected personnel, cool containers with water spray from safe distance
Explosion Risk: Container rupture under intense heat, potential for violent reactions
Personal Protection: Evacuate area, restrict access, wear impermeable gloves, chemical goggles, full-body suit, positive pressure respirator
Environmental Precautions: Prevent entry into drains, soil, waterways, alert local authority if spill threatens wildlife habitats
Spill Cleanup: Absorb with inert material such as dry vermiculite, sand, or earth, collect in suitable non-metallic container, seal and label for hazardous waste disposal
Decontamination: Wash area with alkaline detergent, rinse thoroughly, ventilate affected area
Disposal: Submit cleaned-up material and waste for incineration or hazardous material landfilling
Special Instructions: Avoid sparks, open flames, or smoking during cleanup, do not use aluminum tools
Handling: Protect containers against physical damage, minimize exposure, transfer only in properly ventilated areas, wash hands after use, avoid eating or drinking in work area
Storage: Store in cool, dry, well-ventilated location, secure containers upright, keep away from incompatible chemicals and strong oxidizers, restrict unauthorized access
Container Requirements: Use tightly closed, corrosion-resistant containers, label clearly
Storage Temperature: Maintain at 2–8 °C for maximum shelf life, do not freeze
Special Precautions: Equip storage areas with emergency showers and eyewash stations, post warning signs, keep spill kits and sorbents handy
Occupational Exposure Limits: No established ACGIH or OSHA limits; 0.1 mg/m³ recommended ceiling for similar organophosphates
Engineering Controls: Local exhaust ventilation, closed system transfer, continuous air monitoring where feasible
Personal Protective Equipment: Chemical-resistant gloves (nitrile or butyl), splash goggles, full coveralls, rubber boots, full-face respirator with organic vapor/acid gas cartridge or supplied air system
Hygiene Measures: Remove and wash contaminated clothing before reuse, shower after each shift, no food or drink storage in chemical areas
Emergency Equipment: Eyewash stations, safety showers, first-aid kits readily accessible
Appearance: Colorless to pale yellow oily liquid or crystalline solid
Odor: Faint, aromatic or solvent-like
Boiling Point: Approximately 180–190 °C at reduced pressure
Melting Point: 45–52 °C for pure compound
Vapor Pressure: Low at ambient temperature
Solubility: Insoluble in water, soluble in organic solvents (acetone, xylene, methanol)
Density: 1.33 g/cm³ at 20°C
pH: Not applicable (neutral, non-aqueous liquid)
Flash Point: 110°C (closed cup)
Decomposition Temperature: Above 200°C, releases toxic gases
Partition Coefficient (log Kow): 3.6–4.4 (lipophilic)
Viscosity: Moderate, varies by formulation
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with strong oxidizers, acids, bases, may hydrolyze in presence of moisture
Hazardous Decomposition: Sulfur oxides, phosphorus oxides, nitro compounds, organic vapors on burning
Polymerization: Not expected under normal use
Incompatible Materials: Strong reducing agents, alkali metals, anhydrides
Condition to Avoid: Moisture, high heat, open flames, direct sunlight, prolonged exposure to air
Acute Toxicity: LD50 (oral, rat): 2–6 mg/kg, very toxic by ingestion
Dermal Toxicity: Rapidly absorbed, LD50 (dermal, rat): 10–40 mg/kg
Inhalation: Harmful by inhalation, strong cholinesterase inhibition
Chronic Effects: Cumulative nerve damage with repeated low-level exposure, potential for delayed neurological symptoms
Symptoms of Overexposure: Miosis, bronchoconstriction, bradycardia, convulsions, respiratory arrest
Carcinogenicity: Not listed by IARC or NTP
Mutagenicity: No definitive data; handle as a potential mutagen
Reproductive Toxicity: Evidence from related compounds shows risk of birth defects and fertility impairment
Target Organ Effects: CNS, peripheral nerves, blood cholinesterase
Aquatic Toxicity: Highly toxic to fish and aquatic invertebrates (LC50 <1 mg/L)
Persistence: Low to moderate persistence in soil (t1/2: 1–6 weeks depending on conditions)
Bioaccumulation: High potential in aquatic and land organisms due to lipophilicity
Degradation: Hydrolyzes slowly in water, breaks down faster under aerobic, moist conditions
Mobility: Limited in dry soil, increases sharply with runoff and leaching
Effect on Wildlife: Acutely toxic to bees, mammals, birds; sublethal effects on food chain organisms
Environmental Precautions: Do not allow to contaminate water courses, cropland, or sewage systems, restrict spray drift
Waste Disposal Method: Submit for hazardous waste incineration at licensed facility
Contaminated Packaging: Triple rinse, puncture, and send to certified hazardous waste processor
Special Disposal Codes: Do not dispose with regular trash, do not burn in open pits
Spill Residues: Treat as hazardous waste, neutralize with sodium hydroxide if authorized
Regulatory Requirements: Document all disposal transactions for environmental auditing, retain manifests
Community Protection: Notify licensed waste carriers before transport to disposal site
UN Number: 2783
Proper Shipping Name: Toxic liquid, organic, n.o.s. (O-Ethyl-O-(4-Nitrophenyl)Phenylthiophosphonate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II (medium danger)
Special Provisions: Label as highly toxic, handle by trained personnel, carry safety data sheet during transport
Transport Category: Land (ADR/RID): Class 6.1, Sea (IMDG): Class 6.1, Air (ICAO/IATA): Class 6.1
Environmental Hazard: Marine pollutant, avoid package damage and leaks
Classification: Subject to local, national, and international chemical transport and use regulations; listed as an extremely hazardous substance
Inventory Status: Check with national databases for permitted industrial use
Regulatory Listings: TSCA (US), REACH (EU) regulations, specific national pesticide laws
EU Hazard Statements: H300 (Fatal if swallowed), H310 (Fatal in contact with skin), H400 (Very toxic to aquatic life)
US EPA Status: Restricted use pesticide, permitted for use only by certified personnel
Worker Protection: Follow OSHA Chemical Hygiene Plan, ensure regular health monitoring for users
Restriction Notes: Not for domestic or public domain use, export and import controls in place
