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Product Name: Norfloxacin Nicotinate
Chemical Family: Fluoroquinolone antibiotic derivative
Synonyms: Norfloxacin Nicotinate salt, Norfloxacin 1-pyridinecarboxylate
Molecular Formula: C16H18FN3O3·C6H5NO2
Molecular Weight: Approximately 491.47 g/mol
Recommended Use: Pharmaceutical intermediate, research chemical
Manufacturer: [Company name, address, and emergency contact details]
CAS Number: 72175-20-9 (for Norfloxacin base, check blend)
GHS Classification: Acute toxicity (oral, category 4), Eye irritation (category 2A), Specific target organ toxicity (single exposure, category 3)
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes serious eye irritation; May cause drowsiness or dizziness
Pictograms: Exclamation mark symbol
Precautionary Statements: Do not breathe dust; Wash hands thoroughly after handling; Avoid release to the environment; Wear gloves, eye and face protection
Potential Health Effects: May irritate eyes, skin, and respiratory tract; Prolonged exposure may affect liver and nervous system
Environmental Hazards: Toxic to aquatic life
Chemical Name: Norfloxacin Nicotinate
Active Ingredient: Norfloxacin Nicotinate — 98%
Impurities: Water ≤ 1.0%, Residual solvents ≤ 0.5%, Related substances ≤ 0.5%
Other Components: None indicated
CAS Number: 72175-20-9 (Norfloxacin base), 59-67-6 (Nicotinic acid)
EC Number: 276-972-6 (Norfloxacin)
Inhalation: Move to fresh air. Keep at rest. Loosen clothing. Seek medical advice if symptoms appear.
Skin Contact: Remove contaminated clothes. Rinse skin and wash with soap and water for 15 minutes. Seek attention if irritation or rash develops.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy. Continue rinsing. Consult a physician.
Ingestion: Rinse mouth with water, never give anything by mouth to an unconscious person. Do not induce vomiting. Get medical aid.
Most Important Symptoms: Eye redness, skin irritation, gastrointestinal discomfort, headache, dizziness.
Notes to Physician: Treat symptomatically and monitor for allergic reactions or signs of toxicity.
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, alcohol-resistant foam
Unsuitable Extinguishing Media: Strong water jets
Hazardous Combustion Products: Nitrogen oxides, carbon oxides, fluorine compounds, toxic fumes
Protective Equipment: Self-contained breathing apparatus, full protective clothing
Firefighting Instructions: Move containers away from fire if safe. Prevent fire runoff from entering drains. Cool containers with water spray.
Explosion Hazards: Dust buildup may form explosive mixtures with air.
Personal Precautions: Evacuate area, ventilate, avoid contact with eyes and skin, avoid breathing dust, wear protective gear.
Environmental Precautions: Prevent spillage from entering waterways, sewers, drains. Notify authorities if significant seepage occurs.
Methods for Clean Up: Sweep up and place in suitable, closed containers for disposal. Avoid dust generation. Wash spill area with plenty of water once material is picked up.
Other Precautions: Remove sources of ignition, handle with awareness of potential environmental impact.
Handling: Use only in well-ventilated areas. Avoid breathing dust, fumes, mist. Keep away from food, drink, and animal feed. Practice good hygiene.
Storage Conditions: Store in original container, tightly sealed in a dry, cool, well-ventilated location. Keep away from heat, incompatible substances (oxidizers, acids, bases).
Incompatible Materials: Strong oxidizing agents, reducing agents, acids, bases.
Specific End Use(s): Only intended for laboratory or medication production by qualified personnel.
Occupational Exposure Limits: No established limits; minimize exposure.
Engineering Controls: Use local exhaust ventilation or process enclosures to reduce airborne concentrations. Eyewash stations and emergency showers recommended.
Personal Protective Equipment: Safety goggles, impervious gloves (nitrile, latex), lab coat or protective clothing, dust respirator where dust is generated.
Hygiene Measures: Wash hands after handling. Remove contaminated clothing.
Environmental Controls: Prevent release into water sources. Use containment controls.
Appearance: White to off-white crystalline powder
Odor: Odorless or very slight odor
Odor Threshold: Not noted
pH: 3.5–5.5 (1% aqueous solution)
Melting Point/Freezing Point: 265–280°C (decomposes)
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not available
Flammability: Not classified as flammable
Vapor Pressure: Not determined
Vapor Density: Not available
Solubility: Slightly soluble in water, ethanol; practically insoluble in ether, chloroform
Partition Coefficient (n-octanol/water): 0.2–0.6
Auto-ignition Temp: Not determined
Decomposition Temp: Above 265°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage and handling conditions
Potentially Hazardous Reactions: Reaction with strong oxidizers, acids or bases may produce heat and toxic fumes
Conditions to Avoid: Moisture, heat, direct sunlight, high humidity
Incompatible Materials: Strong acids, bases, oxidizing agents
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, fluorine compounds
Acute Toxicity: LD50 (oral, mouse) ≈ 500–800 mg/kg (for norfloxacin base)
Skin Corrosion/Irritation: May irritate on prolonged contact
Serious Eye Damage/Irritation: Significant eye irritation possible
Respiratory Sensitization: May irritate mucous membranes
Germ Cell Mutagenicity: Limited data; mutagenic potential cannot be ruled out
Carcinogenicity: No detailed data for the salt form; norfloxacin not classified by IARC
Reproductive Toxicity: Animal studies observed developmental toxicity at high doses
Target Organ Effects: Potential neurotoxicity, liver and kidney effects in overdose or long-term exposure
Signs and Symptoms: Headache, dizziness, gastrointestinal upset, skin rash possible
Ecotoxicity: Harmful to aquatic organisms; may cause long-term adverse effects in the aquatic environment
Aquatic Toxicity: LC50 (fish, 96h): <100 mg/L (estimated for norfloxacin)
Persistence and Degradability: Not readily biodegradable; potential for environmental persistence
Bioaccumulative Potential: Low to moderate potential
Mobility in Soil: Likely low mobility; may adsorb to soil particles
Other Adverse Effects: Antibiotic resistance risk if released to the environment
Waste Treatment Methods: Use licensed chemical waste disposal system
Product Disposal: Dispose by incineration in accordance with local regulatory requirements
Contaminated Packaging: Triple rinse containers; treat as chemical waste
Special Precautions: Do not release into waterways, avoid landfill disposal, minimize unnecessary waste generation
UN Number: Not classified as hazardous for air, sea, or road transport
Proper Shipping Name: Norfloxacin Nicotinate
Transport Hazard Class(es): None assigned
Packing Group: None assigned
Special Precautions: Protect from physical damage, moisture; transport in closed containers
Environmental Hazards: Note aquatic toxicity; avoid spills during transport
Safety, Health, and Environmental Regulations: Subject to relevant chemical regulations for pharmaceuticals and laboratory reagents
U.S. OSHA HazCom: Hazardous; see classification
EU REACH/CLP: Not registered; handle based on hazard classification
TSCA, DSL Status: Not listed; for research and development use only
Other Local Regulations: Comply with state, national, and regional regulations for pharmaceuticals, hazardous waste, and workplace safety
Label Requirements: Hazard symbols, precautionary statements, supplier identification on packaging
