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Product Name: Norepinephrine Bitartrate
Synonyms: Levonorepinephrine Bitartrate, Arterenol, Noradrenaline Bitartrate
CAS Number: 108341-18-0
Recommended Use: Laboratory chemical, Pharmaceutical raw material
Manufacturer/Supplier: Contact information available on request
Emergency Telephone: Refer to local poison control center, fire service, or manufacturer hotline
Classification: Acute toxicity (oral, dermal, inhalation), Skin sensitizer, Eye irritant, Specific target organ toxicity
Signal Word: Danger
Hazard Statements: Toxic if swallowed, in contact with skin, or if inhaled. May cause serious skin or eye irritation, possible respiratory sensitization. Target organ effects: cardiovascular system, central nervous system.
Precautionary Statements: Avoid all unnecessary contact. Wear protective equipment. Wash exposed skin thoroughly after handling. Do not breathe dust or powder. Store locked up.
Routes of Exposure: Inhalation, ingestion, dermal, ocular.
Chemical Name: Norepinephrine Bitartrate
CAS Number: 108341-18-0
Concentration: >98% by weight
Impurities: Trace amounts of water, residual solvents, bitartrate byproducts
Molecular Formula: C8H11NO3·C4H6O6
Molecular Weight: 337.3 g/mol
Inhalation: If dust or powder inhaled, move patient to fresh air immediately. Keep person warm and at rest. Initiate artificial respiration if breathing ceases. Seek urgent medical attention.
Skin Contact: Remove contaminated clothing. Rinse skin thoroughly with water and soap. If irritation or symptoms develop, get medical attention.
Eye Contact: Flush eyes with large amounts of water for at least 15 minutes. Remove contact lenses if worn and accessible. Get medical help right away.
Ingestion: Do not induce vomiting. Rinse mouth with water if person is conscious. Never give anything by mouth to an unconscious individual. Seek immediate physician assistance.
Most Important Symptoms/Effects, Acute and Delayed: Headache, palpitations, narrow pupils, anxiety, high blood pressure, arrhythmia, possible convulsions in severe exposure.
Indication of Any Immediate Medical Attention and Special Treatment Needed: Provide symptomatic and supportive treatment. Monitor vital signs and treat for shock if needed.
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam. Avoid direct high-pressure streams.
Specific Hazards Arising from the Chemical: Combustion releases oxides of carbon, nitrogen oxides, and dense smoke. Dust/dispersed powder can form explosive mixtures in air under some conditions.
Protective Equipment and Precautions for Firefighters: Use self-contained breathing apparatus and full protective gear. Evacuate personnel to safe area. Keep containers cooled with water spray.
Advice for Firefighters: Prevent runoff from entering drains and waterways. Remain upwind of fire/explosion zone.
Personal Precautions: Prevent exposure by wearing gloves, goggles, and masks. Avoid breathing dust. Remove all sources of ignition in spill area.
Environmental Precautions: Avoid release to environment. Keep spills out of sewers, watercourses, and confined areas.
Methods for Containment and Cleaning Up: Sweep up loose powder with care to avoid dust formation. Shovel into suitable labelled waste container. Wash contaminated surfaces with plenty of water. Dispose of in accordance with local regulations.
Reference to Other Sections: For appropriate PPE see section on Personal Protection. See Disposal Considerations for waste management.
Precautions for Safe Handling: Wear chemical-resistant gloves, safety glasses, and laboratory coats. Work in well-ventilated areas or fume hoods. Prevent any contact with incompatible substances including strong oxidizing agents.
Conditions for Safe Storage: Store tightly sealed in original container. Keep in cool, dry, and dark area, ideally at 2-8°C in a dedicated chemical refrigerator. Protect from heat, light, and moisture.
Incompatible Materials: Strong acids, strong bases, strong oxidizers, reducing agents.
Occupational Exposure Limits: No established ACGIH, OSHA, or NIOSH exposure limits. Minimize exposure due to pharmacological activity.
Engineering Controls: Use local exhaust or general laboratory ventilation.
Personal Protection: Gloves (nitrile or latex), chemical splash goggles, lab coat or apron. Use P2 or better dust respirator when handling powder or if risk of aerosol generation exists.
Hygiene Measures: Do not eat, drink, or smoke in work area. Wash hands and face thoroughly after handling.
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not available
pH: 3.5-4.5 in 1% aqueous solution
Melting Point/Freezing Point: Approximately 98°C (decomposes)
Boiling Point: Not established (decomposes before boiling)
Flash Point: Not applicable (solid substance)
Evaporation Rate: Not applicable
Flammability: May be combustible as a dust
Vapor Pressure: Not available
Vapor Density: Not available
Relative Density: 1.65 g/cm³ (estimated)
Solubility: Soluble in water, slightly soluble in alcohol
Partition Coefficient n-octanol/water: Not available
Auto-ignition Temperature: Not established
Decomposition Temperature: >98°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions and inert atmosphere. Sensitive to air, moisture, and light.
Possibility of Hazardous Reactions: May react energetically with oxidizers, acids, or alkalis. Risk of dust explosion in finely divided form.
Conditions to Avoid: Exposure to heat, light, moisture, strong acids and bases.
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases, reducing agents.
Hazardous Decomposition Products: Oxides of carbon, nitrogen oxides, irritating fumes.
Likely Routes of Exposure: Inhalation, skin/eye contact, ingestion
Acute Toxicity: LD50 (oral, rat): ~100 mg/kg. Extremely potent and can cause serious effects even at low doses.
Skin Corrosion/Irritation: May cause irritation, redness, and local toxicity if absorbed.
Eye Damage/Irritation: Risk of serious irritation, tearing, and burning.
Respiratory or Skin Sensitization: Sensitization has been reported from occupational or repeated exposure.
Germ Cell Mutagenicity: No indication from available studies.
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA.
Reproductive Toxicity: High-risk in pregnancy; norepinephrine causes vasoconstriction and could harm fetus.
Specific Target Organ Toxicity — Single Exposure: Significant risk to cardiovascular system (tachycardia, hypertension, arrhythmia), nervous system.
Specific Target Organ Toxicity — Repeated Exposure: Risk of cardiac and vascular disorders.
Aspiration Hazard: Not a likely route due to physical state.
Ecotoxicity: Toxic to aquatic life, especially fish and daphnia, if large quantities reach waterways.
Persistence and Degradability: Information scarce, possible slow biodegradation due to aromatic amine structure.
Bioaccumulative Potential: Low expected due to hydrophilic structure.
Mobility in Soil: Possibly mobile in aqueous environments due to solubility.
Other Adverse Effects: Harmful to aquatic organisms even at low concentrations. Prevent bulk waste disposal to environment.
Waste Treatment Methods: Segregate from general chemical waste. Incinerate at high temperature in licensed facility. Small quantities may be adsorbed onto inert material and disposed of as hazardous waste.
Contaminated Packaging: Dispose as chemical waste after decontamination. Do not reuse containers.
Disposal Precautions: Keep material out of municipal sewage systems and open water bodies. Comply with national and local environmental regulations.
UN Number: Not assigned for pharmaceutical ingredient in most jurisdictions; check regional guidance.
Transport Hazard Class: Not regulated under most transport codes. Treat as non-hazardous unless shipped in bulk or special concentration.
Packing Group: Not specified
Environmental Hazards: Not a marine pollutant in small quantites; prevent release to environment.
Special Precautions: Package securely. Protect from moisture, light, and physical damage during transit.
Transport in Bulk: Not intended for bulk transport.
TSCA: Not listed for pharmaceutical applications.
DSL/NDSL (Canada): Not listed for pharmaceutical grade chemicals.
REACH (EU): Exempt for medicinal use. Registration not typically required.
OSHA: No listed permissible exposure limit. Treat as hazardous due to pharmacological potency.
SARA Title III: Not reportable.
California Proposition 65: Not listed.
Other Regulatory Information: Subject to national drug/controlled substance regulations. Follow all federal, state, and local guidelines for possession, handling, distribution.
