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Product Name: Norcantharidin
Chemical Name: 3,6-Endoxohexahydrophthalic anhydride
CAS Number: 5442-12-6
Recommended Uses: Laboratory chemicals, pharmaceutical research, investigational anticancer agent
Supplier Details: Commercial chemical suppliers or relevant pharmaceutical distributors
Emergency Number: Refer to institution’s chemical safety office or local poison control
Synonyms: NCTD, N,N'-Norcantharidin
Formula: C8H8O4
Molecular Weight: 168.15 g/mol
Hazard Classification: Harmful if swallowed, suspected of causing genetic defects, irritating to eyes, skin, and respiratory tract
Signal Word: Warning
Hazard Statements: May cause organ damage through prolonged or repeated exposure; suspected carcinogen status not conclusive; causes mild cytotoxic effects
Pictograms: Exclamation mark, Health hazard
Routes of Exposure: Inhalation, skin absorption, eye contact, ingestion
Target Organs: Kidneys, liver, respiratory system
Potential Effects: Acute toxicity, gastrointestinal discomfort, irritation
Chemical Name: Norcantharidin
CAS Registry No.: 5442-12-6
Purity: >98% (standard laboratory grade)
Impurities: Not specified by supplier; check certificate of analysis
Other Ingredients: None reported
Description: White to off-white crystalline powder
General Advice: Remove from exposure area, consult a physician immediately
Ingestion: Rinse mouth thoroughly, do not induce vomiting, seek medical help
Inhalation: Move person to fresh air, keep at rest, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, rinse skin with water for at least 15 minutes, consult a doctor
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek medical attention
Most Important Symptoms: Gastrointestinal symptoms, irritation, potential nephrotoxicity
Special Notes for Emergency Personnel: Wear protective equipment; avoid contamination
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, water spray
Unsuitable Media: Do not use water jet directly on burning material
Specific Hazards: May emit toxic fumes of carbon oxides when heated to decomposition
Protective Equipment: Firefighters should use self-contained breathing apparatus, full protective gear, avoid inhaling smoke
Flash Point: Data not available, treat as combustible
Advice for Firefighters: Isolate scene and use appropriate tools for chemical fires; avoid runoff to drains
Personal Precautions: Evacuate unnecessary personnel, avoid breathing dust, ventilate area
Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat, particulate respirator
Environmental Measures: Prevent entry into drains, sewers, surface, and ground water
Methods for Cleanup: Avoid creating dust, collect with an inert, non-combustible absorbent material, place in suitable, tightly sealed container for disposal
Disposal: Use safe disposal in accordance with local, regional, and national regulations
Decontamination: Wash spill area with plenty of water
Handling: Use inside fume hood or well-ventilated area, avoid contact with skin, eyes, or clothing, do not breathe dust
Hygiene Practices: Wash hands thoroughly after handling, remove contaminated clothing
Storage Conditions: Store in a cool, dry, well-ventilated place, keep container tightly closed, protect from light and incompatible materials
Incompatible Materials: Strong oxidizers, acids, bases
Handling Precautions: Prevent dust formation, avoid direct exposure, follow laboratory safety protocols
Occupational Exposure Limits: No established TLV or PEL values
Engineering Controls: Use chemical fume hood, safety shower, eyewash station
Personal Protection–Respiratory: Dust mask or respirator (N95 or higher) if dust exposure risk exists
Personal Protection–Skin: Nitrile or neoprene gloves, disposable protective clothing or lab coat
Personal Protection–Eyes: Chemical safety goggles, face shield if risk of splashing
Personal Protection–Other: Closed shoes, handle with care during preparation and transfer
Monitoring: Regular monitoring for airborne dust concentration if used in larger scale or poorly ventilated settings
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Data not available, expected to be neutral in aqueous solution
Melting Point / Freezing Point: 209°C – 213°C
Boiling Point & Range: Not readily volatile
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Data not available; not expected to be highly flammable
Upper/Lower Flammability Limits: Not available
Vapor Pressure: Negligible
Vapor Density: Not applicable
Relative Density: 1.37 g/cm³ (approximate)
Solubility: Slightly soluble in water, soluble in organic solvents like DMSO
Partition Coefficient (log Kow): Not determined
Auto-Ignition Temperature: Not specified
Decomposition Temperature: Decomposes on heating
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Not highly reactive under normal laboratory conditions
Hazardous Reactions: None expected if handled and stored as instructed
Incompatible Materials: Strong oxidizing agents, acids, bases
Decomposition Products: Carbon monoxide, carbon dioxide, possibly toxic fumes
Conditions to Avoid: Excess heat, exposure to light, moisture, sources of ignition, incompatible chemicals
Acute Toxicity: Harmful if ingested, can provoke renal and hepatic effects based on animal data
Skin Corrosion/Irritation: Irritating to skin and mucous membranes
Serious Eye Damage/Irritation: May cause irritation to eyes
Respiratory Sensitization: Dust may cause irritation to respiratory tract
Chronic Toxicity: Evidence from animal studies suggests organ toxicity on prolonged exposure
Carcinogenicity: Not classified as carcinogenic in IARC, NTP, or OSHA listings; data remains incomplete
Mutagenicity: Suspected to induce genetic mutations in cellular assays
Reproductive Toxicity: Insufficient human data
Potential Health Effects: Renal toxicity, gastrointestinal upset, potential cytotoxicity
Toxicity (Aquatic): Toxicity data for aquatic life limited; avoid contamination of waterways
Persistence and Degradability: Expected to be persistent, no significant biotic degradation readily available
Bioaccumulation Potential: Data lacking, not expected to significantly bioaccumulate
Mobility in Soil: Slight water solubility limits rapid movement; adsorption to soil possible
Other Adverse Effects: No known significant effects; handle and dispose of responsibly to reduce environmental impact
Regulatory Reporting: Not listed under persistent organic pollutants but considered hazardous chemical waste
Waste Treatment Methods: Dissolve or mix material with a combustible solvent and burn in a chemical incinerator, equipped with afterburner and scrubber
Container Disposal: Dispose of as hazardous laboratory waste
Legislation: Comply with all applicable local, state, and national environmental regulations
Precautions: Do not allow material to enter drains, surface water, or ground water
Lab-Specific Procedures: Follow university or institutional chemical waste handling protocol; decontaminate surfaces after disposal
UN Number: Not classified as dangerous goods under UN transport regulations
Proper Shipping Name: Laboratory chemicals, not otherwise specified
Transport Hazard Class: Not a regulated class
Packing Group: None specified
Transport Labels: No specific hazard label required
Special Precautions: Ensure packaging is intact, container is sealed, and documentation is included
Road/Rail/Air/Sea Transport: Subject to local chemical transport rules; not considered a major transport hazard unless in bulk quantity
Federal Status (US): Not listed on SARA Title III, CERCLA, or RCRA hazardous waste programs; may be subject to reporting through OSHA hazardous chemical inventory
EU Regulation: Not classified as dangerous under current EC directives but carries risk and safety phrases for laboratory chemicals
Inventory Listings: May appear on TSCA, EINECS/ELINCS but generally handled under controlled laboratory use
Workplace Labelling: Standard chemical hazard label with NFPA or similar rating recommended
Other National Regulations: Observe all applicable regional and country standards for laboratory chemicals
Restriction Statements: For research use only, not for drug, food, or household use
