© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Nitric Oxide
Synonyms: Nitrogen monoxide, NO gas
Chemical Formula: NO
CAS Number: 10102-43-9
Use: Laboratory research, chemical synthesis, semiconductor industry, medical inhalation therapy (pulmonary hypertension)
Supplier Details: Company name, address, emergency contact number available through supplier’s website and product documentation
UN Number: 1660 (for transport and identification)
GHS Classification: Gases under pressure (compressed gas), Acute toxicity (inhalation), Specific target organ toxicity (single exposure), Oxidizing gas
Hazard Statements: Causes severe respiratory irritation and potential pulmonary edema if inhaled, may cause asphyxiation in confined space due to oxygen displacement, forms toxic nitrogen dioxide (NO2) in air, poses risk for environmental damage from uncontrolled release
Pictograms: Gas cylinder, health hazard, oxidizer, exclamation mark
Signal Word: Danger
Precautionary Measures: Prevent inhalation, avoid release to environment, wear protective equipment, keep container in well-ventilated area, handle drip trays and secure valve protection caps during transport and storage
Chemical Name: Nitric Oxide
Concentration: 100% (pure gas)
CAS Number: 10102-43-9
Impurities/Stabilisers: May contain trace impurities identified by manufacturer, oxygen or nitrogen as balance in medical grade mixtures
Inhalation: Move person to fresh air immediately, provide oxygen or artificial respiration as required, seek prompt medical attention for breathing difficulties or cough, delayed symptoms like pulmonary edema possible up to 48 hours post-exposure
Skin Contact: Remove contaminated clothing, rinse skin with water for at least 15 minutes, consult medical staff for lasting irritation
Eye Contact: Rinse thoroughly with water for 15 minutes, hold eyelids open, seek immediate ophthalmological assessment if irritation persists
Ingestion: Ingestion is highly unlikely due to gaseous state, seek medical assessment nonetheless
Note to Physicians: Symptomatic and supportive therapy recommended, monitor for delayed respiratory effects such as noncardiogenic pulmonary edema, observe for methemoglobinemia with lab tests as needed
Flammability: Not flammable, but supports combustion and can intensify fire by increasing oxygen content
Suitable Extinguishing Agents: Use water spray, dry chemical, foam, or carbon dioxide to fight secondary fires involving other combustibles
Specific Hazards: Exposure to heat can cause container rupture or explosion, reacts vigorously with reducing agents and combustibles, produces toxic gases (NO2, N2O) upon thermal decomposition
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full structural turnout gear, remain upwind, remove containers from fire zone if it can be done without risk
Special Precautions: Cool closed containers with water spray to prevent pressure build-up, evacuate area around fire, consider controlling runoff to prevent environmental contamination
Personal Protection: Evacuate personnel to safe areas, ventilate affected area, use self-contained breathing apparatus for cleanup, wear chemical-resistant clothing and gloves, avoid direct skin or eye contact
Environmental Precautions: Prevent release into sewers, waterways, and confined spaces, alert environmental authorities if significant release occurs
Spill Cleanup Methods: Stop leak if safe to do so, vent area to atmosphere, isolate hazard area, remove all sources of ignition, use non-combustible absorbent for containment if in liquid cryogenic form, do not return escaping gas to original container
Decontamination: Wash surfaces with copious water, monitor for presence of NO2 and oxygen levels before area re-entry
Handling: Use only with equipment rated for high pressure and compatible with reactive oxidizing gases, avoid inhaling gas or exposure to leaks, open valves slowly to control flow, inspect connections regularly for corrosion or wear, prevent contact with combustible materials
Storage: Store in cool, dry, ventilated area away from direct sunlight or sources of heat, keep cylinders upright and secure with chains or straps, store away from reducing agents, acids, and organic materials, segregate from incompatible chemicals like ammonia, hydrocarbons, and flammable substances
Special Provisions: Ensure all local and federal guidelines for compressed gas storage are met, prohibit smoking or open flames, maintain legible labels and safety signage
Occupational Exposure Limits: OSHA PEL: Ceiling 25 ppm, NIOSH REL: Ceiling 25 ppm, ACGIH TLV: 25 ppm (as NO)
Engineering Controls: Work under fume hood or in area with local exhaust ventilation, install gas detection and alarm systems for NO and NO2, use leak-proof tubing and regulators
Personal Protective Equipment: Wear safety goggles or face shield, chemical resistant gloves (nitrile, butyl), flame-retardant lab coat or chemical suit, closed-toed shoes, respiratory protection such as NIOSH-approved respirators if exposure likely to exceed OELs
Hygiene Measures: Wash hands after handling, do not eat, drink, or smoke in areas of use, remove contaminated clothing before leaving work area
Physical State: Gas at ambient temperature, colorless, turns reddish-brown in air due to NO2 formation
Odor: Slightly sweet, acrid at higher concentrations
Boiling Point: -151.8°C
Melting Point: -163.6°C
Molecular Weight: 30.01 g/mol
Vapor Density: 1.04 (air = 1)
Solubility: Slightly soluble in water, reacts to form nitrous/nitric acids
Vapor Pressure: High at room temperature
Explosive Properties: Not independently explosive, but promotes combustion in presence of flammable substances
Critical Temperature: -93.1°C
Partition Coefficient: Not applicable, substance diffuses rapidly in air
Chemical Stability: Stable under normal storage and use, rapidly oxidizes in air to brown NO2
Conditions to Avoid: Avoid heat, UV light, sources of ignition, and incompatible materials like reducing agents, alkali metals, hydrides, strong acids, organic compounds
Hazardous Decomposition Products: Nitrogen dioxide, nitrous oxide, nitric acid vapors may generate on exposure or combustion
Polymerization: Does not undergo polymerization
Reactivity: Vigorous reactions with oxygen, ozone, halogens, combustibles, easily forms toxic derivatives upon contact with air
Routes of Exposure: Inhalation is the primary route, skin and eye contact pose irritant risk
Acute Effects: Shortness of breath, cough, headache, chest tightness, delayed pulmonary edema; high-level exposure leads to asphyxiation
Chronic Effects: Prolonged or repeated low-level exposure may result in irreversible lung damage, possible methemoglobinemia, neurological symptoms
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: Limited animal and in vitro data show weak mutagenic potential, high-dose exposure may alter DNA repair
Reproductive Toxicity: Limited evidence for reproductive effects, seek specialist advice for occupational exposure during pregnancy
Target Organs: Lungs, respiratory tract, blood (oxidative stress to hemoglobin)
LD50 / LC50: LC50 (rat, inhalation, 4h): 1068 ppm
Environmental Behavior: Rapidly oxidizes to form NO2, contributes to photochemical smog and acid rain, increases ground-level ozone formation
Aquatic Toxicity: Highly toxic to aquatic organisms when dissolved as nitric acid, leads to acidification of water bodies
Terrestrial Impact: Damages vegetation, alters soil pH, impairs growth of sensitive crops
Persistence and Degradability: Short atmospheric half-life, but byproducts (NO2, nitric acid) persist and exert harmful effects
Bioaccumulative Potential: Not bioaccumulative in organisms, but indirectly shifts ecosystem function
Other Hazards: Contributes significantly to eutrophication and greenhouse gas accumulation through downstream nitrogen cycle effects
Safe Disposal Methods: Evacuate gas in a controlled, well-ventilated system equipped with a scrubbing unit designed for acid gases, do not vent directly to atmosphere, comply with local, regional, and federal disposal regulations
Container Disposal: Empty cylinders should be returned to supplier for reuse or safe disposal, do not attempt to refill or remove valve without training
Sewage/Incineration: Never dispose of NO through general wastewater or incineration, due to toxic byproduct formation
Responsibility: Only trained personnel should undertake disposal activities, record and report all disposal steps as required by environmental authorities
UN Number: 1660
Proper Shipping Name: Nitric Oxide, compressed
Transport Hazard Class: 2.3 (Toxic gas)
Packing Group: Not applicable (compressed gas)
Labeling Requirements: Poison, Oxidizer, Gas under pressure symbols required
Special Transport Precautions: Secure cylinders upright during transit, use ventilated vehicle, keep away from incompatible or combustible cargo
Regulatory Information: Transport subject to U.S. DOT, ICAO/IATA, IMDG, ADR guidelines
OSHA: Listed hazardous substance, workplace exposure monitored and controlled under OSHA Process Safety Management
EPA: Regulated under Clean Air Act as a criteria pollutant and toxic release inventory (TRI) chemical
TSCA: Listed in U.S. Toxic Substances Control Act Inventory
SARA Title III: Classified as an extremely hazardous substance (EHS), detailed reporting required for releases
Global Harmonized System (GHS): Enforced globally, use of hazard pictograms and detailed safety labeling on all containers
Additional Local/State: Always follow additional standards issued by local regulatory bodies, fire marshals, and environmental health & safety agencies for compressed gas handling
