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Product Name: Nitrofurazone
Chemical Formula: C6H6N4O4
CAS Number: 59-87-0
Synonyms: Nitrofural, Furacilin
Recommended Use: Antibacterial topical medication
Supplier: Pharmaceutical or chemical supply company contact details
Emergency Contact: National emergency response numbers, poison control centers
Hazard Classification: Harmful if swallowed, suspected of causing genetic defects, may cause cancer, irritant
Signal Word: Warning
Hazard Statements: H302 - Harmful if swallowed, H341 - Suspected of causing genetic defects, H351 - Suspected of causing cancer
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust, wear protective gloves, wash hands thoroughly after handling, avoid release to the environment
Chemical Name: Nitrofurazone
Concentration: 100% in pure form, diluted in formulations
Impurities: Small traces of related nitrofuran derivatives
Other Ingredients: None in pure substance
Molecular Weight: 198.14 g/mol
Inhalation: Move person to fresh air, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water, use soap if available
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical advice
Symptoms and Effects: Irritation, nausea, headache, potential hemolytic anemia in sensitive individuals
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: No data for strong incompatibility, avoid high-pressure water jets
Specific Hazards: Emits toxic fumes of nitrogen oxides and carbon oxides when heated or burned
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing
Advice for Firefighters: Use caution when approaching fire, cool containing vessels with water spray to prevent explosion
Personal Precautions: Wear gloves, lab coat, chemical goggles, use proper ventilation
Environmental Precautions: Avoid discharge to drains, surface or ground water
Methods for Containment: Sweep up without raising dust, transfer to approved waste container
Cleaning Procedures: Wash spill area with soap and water after initial clean-up
Notification: Inform local authorities if significant spill occurs and contamination of waterways is possible
Handling: Use in well-ventilated areas, avoid inhaling dust or contact with skin and eyes, keep away from incompatible substances
Storage Conditions: Store tightly sealed in original container, cool and dry location, away from strong oxidizers
Storage Temperature: Recommended under 25°C, protect from light
Incompatibilities: Strong acids, strong bases, oxidizing agents
Safe Transfer: Use tools that minimize breakage and dust, label containers clearly
Exposure Limits: Not established by OSHA or ACGIH; minimize exposure by all routes
Engineering Controls: Work in chemical fume hood, use local exhaust ventilation
Personal Protective Equipment: Gloves (nitrile or latex), goggles, lab coat, dust mask or respirator for dusty conditions
Hygiene Measures: Wash hands thoroughly after use, remove contaminated clothing before leaving the workplace
Environmental Exposure Controls: Keep run-off from entering waterways, use spill containment during bulk handling
Appearance: Yellow crystalline powder
Odor: Odorless
pH: Slightly acidic in solution
Melting Point: 236–240°C (dec)
Boiling Point: Not applicable (decomposes)
Solubility: Slightly soluble in water (1 g/L), more soluble in ethanol and DMSO
Density: 1.7–1.8 g/cm³
Vapor Pressure: Negligible
Flash Point: Not applicable
Other Data: Stable under normal conditions, decomposes with prolonged exposure to light or heat
Reactivity: Not highly reactive under recommended handling and storage
Chemical Stability: Stable at room temperature, sensitive to light and moisture
Hazardous Reactions: Decomposes on heating, releasing toxic fumes
Incompatible Materials: Strong oxidizers, strong acids and bases
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, toxic fumes
Routes of Exposure: Inhalation, skin contact, ingestion
Acute Toxicity: Oral LD50 (rat): ~1300 mg/kg
Chronic Effects: Possible carcinogen (IARC 2B), mutagenic effects in laboratory tests, may cause contact dermatitis
Symptoms of Exposure: Irritation to eyes and skin, nausea, allergic reactions in sensitive individuals, potential hepatic and renal effects with prolonged use
Medical Conditions Aggravated: G6PD deficiency, hypersensitivity to nitrofurans
Ecotoxicity: Harmful to aquatic life, potential risk of bioaccumulation
Persistence and Degradability: Not readily biodegradable, persistent in soil and water for extended periods
Mobility in Soil: Limited mobility, may bind to sediments
Other Adverse Effects: Drug residues may contribute to antibacterial resistance in natural water systems
Degradation Products: Unknown toxicity of breakdown products in the environment
Waste Disposal Methods: Dispose of waste at licensed chemical disposal facility, follow local, state, and federal regulations
Contaminated Packaging: Triple rinse, then dispose as chemical waste
Special Instructions: Do not discharge into drains, avoid contamination of surface and groundwater
Disposal Containers: Use sturdy, labeled chemical waste receptacles, ensure compatibility
Recycling and Recovery: Not typically applicable due to toxicity
UN Number: Not classified as hazardous for transport under current regulations
Proper Shipping Name: Nitrofurazone
Transport Hazard Class: Not regulated (consult local transport guidelines for major quantities)
Packing Group: Not assigned
Transport Precautions: Use leak-proof containers, ensure shipment documents include emergency information, protect from moisture and light
Safety, Health and Environmental Regulations: Listed by US EPA as a substance of concern for aquatic environments, IARC 2B (possible human carcinogen), use restricted in certain countries for human or veterinary use, not listed under Canadian WHMIS as a general hazard
TSCA (US): Listed
REACH (EU): Compliance required, check national inventories
OSHA: Not specifically regulated, general chemical safety applies
California Proposition 65: Listed for carcinogenicity
Other US Federal Regulations: Not classified as hazardous waste under RCRA, but caution advised
International Listings: Check local regulations for specific restrictions and permitted uses
