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Product Name: Nitrobenzotrifluoride
Chemical Formula: C7H4F3NO2
Synonyms: Alpha, Alpha, Alpha-Trifluoro-4-nitrotoluene
CAS Number: 402-51-1
Manufacturer: Information available on direct supplier request
Recommended Use: Industrial solvent, manufacturing in dyes, intermediates for pharmaceuticals
Contact Information: Company emergency phone number or local poison control for incidents and questions
Classification: Flammable liquid, Acute toxicity (oral, dermal, inhalation), Skin/eye irritation, Specific target organ toxicity (single exposure)
Hazard Statements: Harmful if swallowed, inhaled, or absorbed through skin. Causes moderate eye, skin, and respiratory irritation. Flammable, vapors may form explosive mixtures with air.
Signal Word: Warning
Pictograms: Flame, Exclamation mark, Health Hazard
Precautionary Statements: Avoid breathing vapors, wash thoroughly after handling, keep container tightly closed, ground and bond container and receiving equipment, use explosion-proof equipment, wear protective gear.
Chemical Name: Nitrobenzotrifluoride
Concentration: Typically 99% or higher
Impurities: Trace organics below reportable thresholds
CAS Number: 402-51-1
Inhalation: Move victim to fresh air, monitor for breathing, administer oxygen if breathing is difficult, seek immediate medical attention.
Skin Contact: Remove contaminated clothing, rinse affected skin with running water for at least 15 minutes, do not apply any creams or ointments unless instructed by a physician, get medical help as soon as possible.
Eye Contact: Rinse thoroughly with clean water for 15–20 minutes, hold eyelids open, remove contact lenses if present, seek urgent evaluation by medical professionals, do not rub eyes.
Ingestion: Do not induce vomiting, rinse mouth with water, never give anything by mouth to an unconscious person, seek immediate medical attention
Advice for First Responders: Use gloves and goggles, provide artificial respiration if needed, keep airway clear, transport to hospital with MSDS copy.
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, or water spray, only use water spray to cool containers, not directly on fire if possible
Specific Hazards: Vapors can travel significant distances to ignition sources and cause flashback, fire may produce toxic and corrosive gases including hydrogen fluoride, nitrogen oxides, carbon oxides
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus, full body chemical protective clothing
Fire Fighting Instructions: Approach from upwind, use water to keep containers cool, avoid run-off to sewers and waterways, withdraw immediately in case of rising sound from vent or discoloration of container.
Personal Precautions: Evacuate non-essential personnel, ventilate area, remove ignition sources, restrict access until cleanup is finished, wear gloves, chemical-resistant boots, splash goggles, and apron
Environmental Precautions: Prevent release to drains, surface, and groundwater; dike spills with non-combustible material, notify appropriate environmental authorities in case of significant release
Methods for Cleanup: Absorb spills with sand, earth, or vermiculite, use spark-proof and non-sparking tools, place waste in approved containers, wash spill area with detergent solution, ventilate and monitor area for residual vapors
Handling: Work in well-ventilated spaces, use spark-resistant equipment, avoid unnecessary skin or eye contact, do not eat, drink, or sniff near chemical, keep away from heat, sparks, open flames, and static discharge sources, avoid creating aerosols or mist
Storage: Store in original, tightly sealed containers in cool, dry, well-ventilated areas, keep away from incompatible materials (strong bases, oxidizing agents, reducing agents), protect from direct sunlight, ensure area has spill containment and eyewash station, label storage area with hazard classifications, restrict access to trained personnel only
Engineering Controls: Use local exhaust ventilation and process enclosure to reduce exposure, monitor airborne concentrations regularly, install explosion-proof ventilation systems and electrical fixtures
Occupational Exposure Limits: No specific OSHA/ACGIH limit, recommend time-weighted average below 1 ppm as a conservative safety measure
Personal Protective Equipment: Nitrile or neoprene gloves, chemical splash goggles or face shield, flame-resistant lab coat or coveralls, closed-toe chemical-resistant footwear
Respiratory Protection: Use NIOSH-approved cartridge respirators for organic vapors if exposure exceeds safe levels
Hygiene Measures: Do not smoke, eat, or drink around chemical, wash hands before breaks and after work, remove contaminated clothing promptly
Appearance: Colorless to pale yellow liquid
Odor: Sweet, aromatic
pH: Not applicable (non-aqueous)
Melting Point: -24°C
Boiling Point: 174°C
Flash Point: 58°C, closed cup
Evaporation Rate: Slower than ether
Vapor Pressure: 3.3 mmHg at 25°C
Vapor Density: Heavier than air (approx. 5.1)
Solubility: Slightly soluble in water, miscible with common organic solvents
Density: 1.43 g/cm³ at 20°C
Autoignition Temperature: 520°C
Partition Coefficient (log Kow): Approx. 3.6
Chemical Stability: Stable under normal temperature and pressure, may degrade under prolonged exposure to intense light or heat
Hazardous Reactions: Reacts vigorously with strong bases, alkalis, oxidizers, reducing agents, may form hazardous byproducts
Decomposition Products: Hydrogen fluoride, nitrogen oxides, carbon oxides, possible toxic perfluorinated compounds
Conditions to Avoid: High temperatures, open flames, incompatible chemicals, physical shock, moisture ingress
Acute Toxicity: Oral LD50 (rat): approx. 800 mg/kg, Inhalation LC50: not well defined, dermal absorption may cause systemic effects
Skin/Eye Irritation: Irritating to skin and eyes, can cause redness, burning, or ulceration
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: Drowsiness, headaches, irritation of mucous membranes, coughing, nausea, possible chemical pneumonitis in severe inhalation cases
Chronic Effects: Liver and kidney damage reported in animal studies after repeated exposure, potential risk of sensitization on contact
Carcinogenicity: Not classified as carcinogen by IARC, OSHA, or NTP
Mutagenicity: Not conclusively established, some test data indicate possible mutagenic effects
Persistence and Degradability: Not rapidly biodegradable, persists in aquatic environments, potential to bioaccumulate
Toxicity to Aquatic Life: LC50 (fish, 96h): ranges from 20–50 mg/L, moderate toxicity to daphnia and algae
Mobility: Limited water solubility means it may adsorb to soils and sediments
Potential Risks: Possible risk of long-term adverse effects in the aquatic environment, avoid release to natural waters, wastewater treatment may not remove all residues effectively
Other Adverse Effects: No known significant effects on ozone or long-term ecological processes
Waste Treatment Methods: Incinerate using thermal oxidation in permitted chemical incinerator with afterburner and scrubber, avoid landfill when possible
Contaminated Packaging: Rinse containers completely, treat rinsate as hazardous, send for certified hazardous waste recycling or disposal
Disposal Regulations: Comply with all local, regional, and national hazardous waste regulations, do not pour down drains, incinerate or bury in lined, sealed disposal sites only
Precautions: Document all disposals, keep MSDS with outgoing waste materials
UN Number: 2810
Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains Nitrobenzotrifluoride)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Label Requirements: Toxic, flammable symbols required
Environmental Hazards: Marine pollutant marking recommended for international shipments
Special Precautions: Avoid loading with incompatible materials or foodstuffs, emergency response guides must accompany shipment, transport in secured, upright, leak-proof containers
OSHA Hazard Category: Acute health hazard, fire hazard, toxic substance
SARA Title III, Section 313: Listed as reportable toxic chemical, threshold quantity applies
TSCA Status: Listed
DSL/NDSL (Canada): Listed on Domestic Substances List
REACH (EU): Pre-registered, restrictions may apply pending updated EC safety review
Other Global Regulations: Handled as a regulated hazardous chemical in most jurisdictions, consult national authorities for specific rules, risk assessment required for workplace use, spill, and waste management plans strongly recommended
