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Product Name: Nimustine Hydrochloride
Chemical Name: 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea hydrochloride
Synonyms: Nimustine; ACNU
CAS Number: 37852-70-7
Molecular Formula: C9H13ClN4O2·HCl
Recommended Use: Research, cytostatic drug for cancer treatment
Supplier Information: Manufacturer or distributor will have detailed address and contact for emergencies.
Emergency Phone: Consult local regulations and supplier instructions for emergency numbers.
Hazard Class: Acute toxicity, carcinogenicity, organ toxicity
Signal Word: Danger
Hazard Statements: May cause cancer by inhalation, ingestion, or skin absorption. Toxic if swallowed or in contact with skin. Potentially mutagenic and teratogenic. Damages blood, liver, and kidneys. Causes irritation to skin, eyes, and respiratory tract.
Precautionary Statements: Avoid all contact. Use personal protective equipment. Prevent environmental contamination.
Pictograms: Skull and crossbones, Health hazard
Chemical Component: Nimustine Hydrochloride
Concentration: Typically greater than 98% purity for laboratory grade material
Impurities: Manufacturer-specific details available upon request, low levels of related compounds
Inhalation: Move subject to fresh air. Seek immediate medical attention. Provide oxygen if breathing is difficult.
Skin Contact: Remove contaminated clothing. Rinse skin with plenty of water for at least 15 minutes. Wash thoroughly with soap. Medical evaluation needed.
Eye Contact: Rinse eyes with flowing water for at least 15 minutes, holding eyelids apart. Get medical help without delay.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly with water. Immediate medical attention critical.
General Advice: Get medical attention immediately in all cases of exposure. Show MSDS to attending physician. Persons handling the compound on a regular basis should receive specific training in managing chemical exposures.
Suitable Extinguishing Media: Use carbon dioxide, dry chemical powder, foam, or water spray.
Unsuitable Extinguishing Media: High-volume water jet may spread material.
Specific Hazards: Emits toxic fumes of nitrogen oxides, hydrogen chloride, chlorine, and carbon oxides during fire.
Advice for Firefighters: Wear full-body, self-contained breathing apparatus and protective gear. Approach from upwind.
Special Protective Measures: Evacuate area. Use water spray to cool closed containers. Prevent fire-fighting run-off from contaminating water supplies.
Personal Precautions: Isolate area and avoid direct contact. Use NIOSH-approved respirator, chemical-resistant gloves, protective coveralls, and eye protection.
Environmental Precautions: Prevent entry into drains, waterways, or soil. Notify authorities if material enters environment.
Methods for Cleanup: Use only trained personnel. Scoop or sweep up without raising dust. Place in chemical waste container. Ventilate area and decontaminate surfaces with appropriate agent. Dispose of waste in line with local regulations.
Handling: Handle in chemical fume hood. Avoid breathing dust or vapors. Avoid contact with skin, eyes, and clothing. Do not eat, drink, or smoke while working. Decontaminate all equipment after use.
Storage: Store in tightly closed container in cool, dry, well-ventilated area. Protect from light. Keep separate from food and incompatible substances such as strong oxidizing agents.
Incompatibilities: Strong acids, strong bases, oxidizing agents.
Engineering Controls: Use certified chemical fume hood and local exhaust ventilation.
Personal Protection: Protective gloves (nitrile or neoprene), lab coat, chemical splash goggles, and properly fitted respiratory protection as per safety guidelines.
Hygiene Measures: Wash hands, face, and exposed skin after handling. Contaminated clothing must be laundered before reuse.
Exposure Limits: No occupational exposure limits set by OSHA or ACGIH; follow internal guidelines and safety procedures for cytotoxic agents.
Appearance: White to pale-yellow crystalline powder
Odor: No distinctive odor
Melting Point: 160-163°C
Solubility: Soluble in water, methanol, and ethanol
pH: 3.0-5.0 (1% solution in water)
Molecular Weight: 277.7 g/mol (base), 314.2 g/mol (hydrochloride)
Boiling Point: Data not available (decomposes)
Vapor Pressure: Not significant under ambient conditions
Partition Coefficient: Log Kow approximately 0.06
Flash Point: Not applicable (non-flammable solid)
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Decomposes on prolonged exposure to moisture, heat, or light with release of toxic fumes.
Hazardous Reactions: May react with oxidizing acids and bases to release hazardous gases.
Decomposition Products: Carbon monoxide, nitrogen oxides, hydrogen chloride, chlorine.
Incompatibilities: Strong oxidizers and reducing agents accelerate decomposition.
Acute Toxicity: Categories for oral, dermal, and inhalation routes indicate high toxicity.
Carcinogenicity: Classified as carcinogenic to humans based on animal data and usage in cancer therapy.
Mutagenicity: Causes genetic mutations, confirmed by in vitro and in vivo studies.
Reproductive Toxicity: Harmful to developing fetus and may impair fertility.
Target Organs: Bone marrow, liver, kidney, gastrointestinal tract, immune system.
Symptoms of Exposure: Nausea, vomiting, abdominal pain, anemia, immunosuppression, increased risk of infection, hemorrhagic complications.
Sensitization: Not established, but repeated exposure increases risk of allergic reactions.
Aquatic Toxicity: Toxic to aquatic life, risk of long-term adverse effects in aquatic environments.
Persistence and Degradability: Not readily biodegradable, may persist in environment.
Bioaccumulative Potential: Potential for bioaccumulation low given chemical properties, but breakdown products may persist.
Mobility in Soil: Moderate mobility expected; compound can leach into groundwater.
Additional Information: Avoid release to natural water sources and sewers. Environmental hazard is elevated in case of uncontrolled disposal.
Waste Treatment: Use a licensed chemical waste disposal contractor. Treat as hazardous pharmaceutical waste.
Contaminated Packaging: Contaminated containers must be triple-rinsed and managed as hazardous waste.
Disposal Guidance: Incinerate in a controlled facility in compliance with local regulations. Do not discharge to sewer or land.
Regulations: Follow US EPA, EU, and regional hazardous waste guidelines.
UN Number: UN2811 (Toxic Solid, Organic, N.O.S.)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II (medium danger)
Shipping Name: Toxic solid, organic, n.o.s. (contains Nimustine Hydrochloride)
Special Precautions: Prevent release into environment during transport. Ensure packaging is secure and labeled. Carried only by authorized personnel certified for hazardous shipments.
Regulatory Codes: Refer to IATA, IMDG, DOT, ADR standards for exact handling and documentation advice.
TSCA: Not listed for commercial sale in the US under TSCA.
OSHA: Handled under regulations for toxic and hazardous drugs; classify lab and handling areas according to OSHA standards for cytotoxic agents.
RCRA: Listed as a hazardous waste (U.S.) based on toxic properties.
EU Regulations: Classified according to CLP Regulation (EC) No 1272/2008; hazard category: Carcinogen Category 1B.
Other: Follow national, regional, and international guidelines on handling, use, and disposal of cytotoxic agents. Facility should keep records of usage and incidents as per regulatory requirements.
