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Product Name: Nicotine Salicylate
Chemical Formula: C14H17NO2
CAS Number: 4418-20-8
Synonyms: Salicylic acid nicotine salt
Recommended Use: Laboratory chemical, ingredient in e-liquid, pharmaceutical research
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Classification: Acute Toxicity (Oral, Dermal, Inhalation) Category 2; Eye Irritant Category 2A; Skin Corrosive/Irritant Category 2
Hazard Statements: Fatal if swallowed, inhaled, or absorbed through skin; Causes skin and eye irritation
Signal Word: Danger
Hazard Symbols: Skull and crossbones, exclamation mark
Precautionary Statements: Avoid breathing dust, fumes, or vapors; Use protective gloves and eye/face protection; Wash skin thoroughly after handling
Routes of Exposure: Inhalation, ingestion, skin absorption
Target Organs: Nervous system, respiratory system
Chemical Name: Nicotine Salicylate
PURITY: 98% or above
Primary Constituents: Nicotine (approx. 50% by weight), Salicylic acid (approx. 50% by weight)
Impurities or Stabilizers: None reported in pharmaceutical-grade samples
CAS Numbers: Nicotine: 54-11-5; Salicylic acid: 69-72-7
Inhalation: Move affected person to fresh air immediately; Administer artificial respiration if breathing has stopped; Call emergency medical services
Skin Contact: Remove contaminated clothing; Immediately wash skin with soap and water for at least 15 minutes; Seek medical attention
Eye Contact: Rinse cautiously with water for at least 15 minutes; Remove contact lenses if present; Seek ophthalmologist aid
Ingestion: Rinse mouth; Do not induce vomiting; Immediately call a physician or poison center
Notes for Physicians: Treatment focused on symptomatic and supportive care; Monitor for nicotine toxicity and salicylate poisoning
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, water spray, foam
Unsuitable Media: Direct water jet
Specific Hazards: Combustion produces toxic fumes including nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment for Firefighters: Wear full protective gear and self-contained breathing apparatus
Special Procedures: Isolate hazard area; Remove containers from fire zone if safe; Use water spray to keep containers cool
Personal Precautions: Wear gloves, laboratory coat, eye protection, face shield, and respiratory protection in poorly ventilated areas
Environmental Precautions: Prevent spillage from entering waterways, soil, or drainage systems
Cleanup Methods: Absorb with inert material (sand, vermiculite); Collect in suitable containers for disposal; Ventilate area thoroughly
Spill Response: If a large spill occurs, evacuate area and contact emergency personnel
Handling: Manipulate only in well-ventilated areas; Avoid skin, eye, and clothing contact; Avoid inhaling dust or vapor; Do not eat, drink, or smoke during use
Storage Conditions: Store in tightly closed container; Place in cool, dry, well-ventilated, secure area away from incompatible substances (oxidizers, acids, alkalis)
Storage Temperature: Recommended 2-8°C; Avoid exposure to heat, direct sunlight, or moisture
Special Precautions: Keep out of reach of children; Clearly label all containers; Regular inspection of storage area is advised
Exposure Limits: Nicotine Occupational Exposure Limit (OEL): 0.5 mg/m³ (8h TWA)
Engineering Controls: Local exhaust ventilation, safety showers, eye-wash stations
Personal Protective Equipment: Chemically resistant gloves (nitrile/rubber), protective clothing, safety goggles, face shield, respiratory protection if airborne concentration exceeds OEL
Hygiene Measures: Wash hands and exposed skin after handling; Remove contaminated clothing before entering eating areas
Appearance: Off-white to pale beige crystalline powder
Odor: Characteristic, fishy, tobacco-like
Molecular Mass: 231.29 g/mol
pH (solution): Approximately 5-7 (1% aqueous)
Melting Point: 98 to 110 °C
Boiling Point: Decomposes before boiling
Flash Point: Data not precise but typically above 90°C
Solubility: Soluble in water, ethanol, chloroform
Vapor Pressure: Low at ambient conditions
Partition coefficient (LogPow): Estimated 1-2
Stability: Stable under recommended storage; Hygroscopic
Reactivity: Sensitive to strong acids, oxidizers
Chemical Stability: Stable under recommended storage and handling
Conditions to Avoid: Heat, sparks, open flames, exposure to light, moisture
Hazardous Decomposition: Releases toxic nitrogen oxides, carbon oxides upon decomposition
Incompatible Materials: Strong oxidizers, reducing agents, strong acids or alkalis
Polymerization: No hazardous polymerization anticipated
Acute Toxicity: Highly toxic by ingestion, inhalation, and skin contact; LD50 (oral, rat) nicotine component 50–60 mg/kg
Skin Corrosion/Irritation: Causes moderate skin irritation and may be absorbed through skin
Eye Damage/Irritation: Causes severe eye irritation
Respiratory Sensitization: Inhalation may cause symptoms of nicotine poisoning including dizziness, confusion, tremor, and convulsions
Long-Term Effects: Chronic exposure linked to CNS effects, cardiovascular symptoms, and addiction
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Additional Information: Symptoms of poisoning can include salivation, nausea, vomiting, abdominal pain, respiratory difficulties, seizures, and death
Aquatic Toxicity: Very toxic to aquatic life; EC50 (Daphnia magna, 48h): 1 mg/L (nicotine component)
Persistence and Degradability: Nicotine portion may persist in the environment
Bioaccumulative Potential: Bioaccumulation is possible
Mobility in Soil: Moderate mobility expected due to water solubility
Other Adverse Effects: Toxic to bees and other invertebrates; Avoid any release to natural waters or soil
Waste Treatment Methods: Incinerate in approved facility; Do not mix with household waste
Disposal of Packaging: Contaminated packaging must be disposed in accordance with local, regional, and national regulations
Special Precautions for Disposal: Avoid release to the environment; Consult local regulatory authorities for guidance
Recommended Measures: Use licensed hazardous waste disposal contractors
UN Number: UN 1654 (Nicotine, solid, for shipping reference)
UN Proper Shipping Name: Nicotine salts
Transport Hazard Class: Class 6.1 (Toxic substances)
Packing Group: II (Medium danger)
Marine Pollutant: Yes
Special Precautions: Keep away from food and animal feed during transport; Secure packaging to prevent leaks
Regulatory References: ADR, IMDG, IATA require compliance with toxic substance shipping rules
OSHA Status: Regulated as highly toxic substance
TSCA Listing: All components listed
SARA Title III: Does not trigger Section 313 reporting thresholds
European Union (CLP): Classified as Acute Tox. 2, Skin Irrit. 2, Eye Irrit. 2A
REACH Status: Registered under REACH in EU for laboratory and research use
Other National Regulations: Subject to strict controls under poisons legislation in most jurisdictions
Labelling Requirements: Poison symbol, risk and safety phrases, emergency contact information
