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Product name: Nicotinamide
Synonyms: Niacinamide, Vitamin B3 amide
Chemical formula: C6H6N2O
CAS number: 98-92-0
Molecular weight: 122.13 g/mol
Manufacturer: Pharmaceutical raw material supplier details
Recommended use: Ingredient in pharmaceutical products, dietary supplements, cosmetics
Emergency contact: Local poison control center, manufacturer’s emergency phone
Classification: Not classified as hazardous under GHS
Main hazards: Mild irritant for eyes and skin, low acute toxicity, dust may cause respiratory irritation
Signal word: None required
Pictograms: Not required
Hazard statements: May cause eye irritation, may cause mild skin discomfort and dryness, inhalation of dust can cause coughing and throat dryness
Precautionary statements: Avoid generating dust, avoid contact with eyes, wash hands after handling
Chemical: Nicotinamide
Concentration: ≥99%
Impurities: Trace impurities within pharmaceutical standards
Eye contact: Rinse immediately with plenty of water, remove contact lenses if present, continue rinsing, seek medical attention if irritation persists
Skin contact: Wash thoroughly with soap and water, remove contaminated clothing, get medical attention if rash develops
Inhalation: Move person to fresh air, keep at rest, seek medical advice if adverse symptoms occur
Ingestion: Rinse mouth, drink water, do not induce vomiting, seek medical attention if feeling unwell
Most important symptoms: Irritation, redness, mild burning sensation
Suitable extinguishing media: Dry chemical, water spray, carbon dioxide, foam
Specific hazards: Emits toxic fumes of nitrogen oxides and carbon oxides under fire conditions
Protective equipment: Self-contained breathing apparatus, protective suit for firefighters
Advice for firefighters: Evacuate area, fight fire from safe distance, prevent runoff from entering drains or water bodies
Personal precautions: Use personal protective equipment, avoid dust formation, ventilate area
Environmental precautions: Do not allow product to enter drains, water courses, or soil
Methods for cleaning up: Sweep up and shovel into a suitable container for disposal, clean contaminated surface thoroughly, avoid raising dust
Handling procedures: Use in well-ventilated areas, avoid breathing dust, wear protective clothing and gloves, avoid eye and skin contact, wash thoroughly after handling
Storage conditions: Keep container tightly closed, store in a cool, dry, well-ventilated place, protect from light, segregate from incompatible substances such as strong oxidizers and acids
Exposure limits: No occupational exposure limits set for nicotinamide
Engineering controls: Local exhaust ventilation, dust extraction
Personal protective equipment: Safety glasses with side shields, chemical-resistant gloves, lab coat or overalls, dust mask for airborne particulates
Hygiene measures: Wash hands, forearms, and face after handling, remove and wash contaminated clothing
Appearance: White, odorless, crystalline powder
Solubility: Freely soluble in water and ethanol
Melting point: ~128-131 °C
Boiling point: Decomposes before boiling
pH (5% in water): 6.0–7.5
Flash point: Not applicable under normal conditions
Vapor pressure: Negligible at room temperature
Density: ~1.4 g/cm³
Partition coefficient: Log Pow -0.37
Chemical stability: Stable under recommended conditions
Reactivity: Not reactive under normal use and storage
Incompatible materials: Strong oxidizing agents, acids, bases
Hazardous decomposition: Nitrogen oxides, carbon oxides liberated at elevated temperatures
Polymerization: Does not occur
Acute toxicity: Oral LD50 rat: over 5,000 mg/kg – indicates low toxicity
Skin irritation: Not classified as a skin irritant
Eye irritation: May cause mild, transient irritation
Respiratory: Dust can cause upper airway irritation
Chronic effects: High oral doses over extended periods can cause liver toxicity and other systemic effects
Carcinogenicity: Not classified as carcinogen, not listed by IARC, NTP, OSHA
Mutagenicity: No evidence from animal studies to support mutagenic risk
Reproductive toxicity: No adverse effects at recommended doses in animal models
Ecotoxicity: No adverse effects on aquatic life at expected environmental concentrations
Mobility: Readily soluble, may leach into groundwater
Persistence and degradability: Biodegradable under aerobic conditions
Bioaccumulation: Not expected to bioaccumulate
Other adverse effects: No significant environmental hazards identified
Product disposal: Dispose of in accordance with local, regional, and national regulations
Container disposal: Rinse thoroughly, dispose of as chemical waste
Precautions: Prevent material from entering water sources or soil
UN number: Not regulated as dangerous goods
Proper shipping name: Nicotinamide, Pharmaceutical Grade
Transport hazard class: Not applicable
Packing group: Not applicable
Special precautions: Avoid excessive heat and moisture during transport
Labeling: No special hazard labeling required under GHS or local standards
Chemical Inventory Listings: Registered or exempt under applicable regulations such as US TSCA, EU REACH
Other applicable regulations: FDA-approved for use in pharmaceuticals and supplements, subject to GMP requirements for pharmaceutical use
Worker protection: Refer to OSHA standards for general chemical hygiene and lab safety practices
International regulations: Status allows for use in medicines, foods, and cosmetics in many jurisdictions
