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Product Name: Niclofolan
CAS Number: 1975-20-2
Recommended Uses: Veterinary anthelmintic
Manufacturer: Refer to product Packaging
Emergency Telephone: See national emergency contact list
Address: See company details on official documentation
GHS Classification: Toxic if swallowed, causes skin irritation, causes serious eye irritation, suspected of damaging fertility or the unborn child, very toxic to aquatic life
Hazard Pictograms: Skull and crossbones, exclamation mark, health hazard, environment
Signal Word: Danger
Hazard Statements: Harmful if swallowed; causes skin and eye irritation; suspected of reproductive toxicity; highly toxic to aquatic organisms, with long-lasting effects
Precautionary Statements: Avoid inhalation, ingestion, and skin or eye contact; use appropriate PPE; avoid release to the environment
Chemical Name: Niclofolan
Synonyms: 2-(2’,4’-Dichlorophenyl)-2-methylthio-N-nitroethanamine
Molecular Formula: C9H10Cl2N2O2S
Molecular Weight: 297.16 g/mol
Concentration: >95% (technical grade)
Impurities and Stabilizers: Trace organic solvents, residuals ≤1%
General Advice: Take patient to fresh air; remove contaminated clothing; provide symptomatic care
Inhalation: Move affected person to fresh air, keep at rest, and monitor breathing
Skin Contact: Wash thoroughly with plenty of soap and water; seek medical advice if symptoms occur
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing
Ingestion: Rinse mouth thoroughly but do not induce vomiting; seek immediate medical assistance
Most Important Symptoms: Nausea, irritation, headache, allergic reaction, dizziness
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Unsuitable Media: Direct water stream increases risk of wider contamination
Hazards: Decomposition releases toxic fumes including hydrogen chloride, nitrogen oxides, sulfur oxides
Protective Equipment: Wear self-contained breathing apparatus and full protective clothing
Special Procedures: Prevent contaminated water runoff entering drains or watercourses; isolate hazard area
Personal Precautions: Use recommended personal protective equipment, ventilate area, avoid dust or aerosol formation
Environmental Precautions: Prevent further leakage or spillage without harming remedial personnel; do not let product enter drains, waterways, or soil
Methods for Containment: Spill should be covered with inert absorbent material, collected, and placed in appropriate labeled containers for disposal
Methods for Cleaning Up: Clean area with detergent and water, ventilate affected zone, monitor air quality if dust develops
Protective Measures: Use with adequate ventilation; minimize dust generation; avoid breathing dust, vapors, or mist
Safe Handling Advice: Wear protective gloves, chemical safety goggles, and appropriate clothing; do not eat, drink, or smoke during handling
Storage Conditions: Keep container tightly closed in a dry, cool, and well-ventilated area; avoid exposure to heat, sparks, open flame
Incompatible Materials: Strong oxidizers, strong acids or bases
Special Storage Requirements: Store locked up, label all containers
Occupational Exposure Limits: No specific official limit; minimize exposure as low as possible
Engineering Controls: Use local exhaust ventilation; handling in closed systems recommended
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, protective clothing, appropriate respiratory protection for dust or fumes
Hygiene Measures: Wash hands before breaks and after handling; do not eat or drink in work area
Appearance: Off-white to yellowish powder
Odor: Faint, not distinctive
Odor Threshold: Not determined
pH: Not applicable (solid material)
Melting Point: 86-89°C
Boiling Point: Decomposes before boiling
Flash Point: Not established
Evaporation Rate: Not determined
Flammability: Not classified as flammable
Vapor Pressure: Very low at 20°C
Solubility: Poorly soluble in water; soluble in organic solvents (e.g., chloroform, ethanol)
Partition Coefficient (log Kow): Estimated value >3
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Tends to decompose above 120°C
Viscosity: Not applicable
Chemical Stability: Stable under normal use and storage conditions
Reaction Risks: Reacts vigorously with strong acids, bases, and oxidizers
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, sulfur oxides may form during thermal decomposition
Conditions to Avoid: Excessive heat, open flames, direct sunlight, incompatible materials
Acute Toxicity (Oral): LD50 rat ≈ 200 mg/kg
Acute Toxicity (Dermal): Not well established; possible moderate hazard
Skin Corrosion/Irritation: Causes irritation on prolonged or repeated contact
Serious Eye Damage/Eye Irritation: Causes eye irritation
Respiratory or Skin Sensitization: Limited data; allergic reactions possible
Germ Cell Mutagenicity: Data not conclusive
Carcinogenicity: No classification based on current evidence
Reproductive Toxicity: Suspected, needs further examination; precautionary measures advised
Target Organ Toxicity: Data limited but includes liver and kidney effects with high exposures
Symptoms: Nausea, vomiting, abdominal pain, headache, skin rash, eye redness
Aquatic Toxicity: Very toxic to aquatic organisms, values for LC50 (fish) <1 mg/L
Persistence and Degradability: Moderately persistent in soil/water
Bioaccumulative Potential: Evidence of bioaccumulation likely due to log Kow >3
Mobility in Soil: Tends to bind to soils, potential for leaching depends on conditions
Other Adverse Effects: Harmful to aquatic invertebrates, long-term hazards to aquatic systems
Product Disposal: Dispose of by incineration in approved facility; avoid uncontrolled releases
Container Disposal: Thoroughly clean containers prior to recycling or disposal; follow local and national regulations
Precautions: Do not allow material to enter groundwater or public wastewater systems; consult local hazardous waste guidelines for pesticide disposal
UN Number: 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains Niclofolan)
Transport Hazard Class: Class 6.1 (Toxic substances)
Packing Group: II
Environmental Hazards: Marine pollutant
Special Precautions: Handle and transport using appropriate safety procedures as outlined in hazardous material regulations
Labeling Requirements: Comply with local, national, and international labeling rules for hazardous chemicals
TSCA Status: Not listed (consult US regulations)
REACH Status: Not registered or not applicable
Other Regulations: Subject to pesticide regulations in multiple jurisdictions, observe additional restrictions or reporting obligations per country
Workplace Restrictions: Only authorized, properly trained personnel permitted to handle
Note: Users must review regional regulations, including workplace and environmental controls, before use
