© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Nicergoline
Synonyms: Nicergolina, Sermion
Chemical Family: Ergoline derivatives
Molecular Formula: C24H26N4O3
Molecular Weight: 426.49 g/mol
Manufacturer: [Enter manufacturer name]
Emergency Phone: [Enter emergency contact number]
Recommended Uses: Pharmaceutical ingredient, research chemical
GHS Classification: Not classified as hazardous under GHS standards for pure substance
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Health Hazards: Irritation to eyes and skin, respiratory discomfort if inhaled
Chronic Effects: Potential for headache, dizziness, gastrointestinal discomfort based on pharmacological activity
Environmental Impact: Not expected to cause acute ecological issues in typical lab settings but limited aquatic data available
Signal Word: Caution
Chemical Name: Nicergoline
CAS Number: 27848-84-6
Concentration: ≥98% (active substance)
Impurities: Trace solvents, ergoline analogs (<1%)
General Advice: Move individual away from source of exposure and supply fresh air
Inhalation: Remove to fresh air promptly, consult physician if cough or difficulty breathing
Eye Contact: Rinse carefully under running water for at least 15 minutes, seek medical care if irritation persists
Skin Contact: Wash thoroughly with soap and water
Ingestion: Rinse mouth with water, seek medical advice if feeling unwell
Symptoms: Nausea, headache, skin redness, watery eyes possible based on chemical nature
Extinguishing Media: Water spray, carbon dioxide, dry chemical, alcohol-resistant foam
Hazardous Combustion Products: Oxides of carbon, nitrogen oxides, and noxious fumes
Protective Equipment: Wear self-contained breathing apparatus with full protective gear
Specific Hazards: Powdered product can form combustible dust clouds
Advice for Firefighters: Avoid inhaling fumes; keep containers cool with water spray to prevent pressure build-up
Personal Precautions: Wear gloves, lab coat, and safety goggles; avoid dust generation
Environmental Precautions: Prevent product from contacting soil, waterways, drains
Containment: Sweep up gently with minimal dust, collect in labeled waste bin
Cleaning Methods: Wash minor residues with plenty of water and detergent, ventilate area well
Handling: Use in well-ventilated area with appropriate PPE; minimize dust formation
Storage Conditions: Store in a cool, dry location in tightly closed container, away from direct sunlight and strong oxidizers
Special Storage Instructions: Segregate away from acids, alkalis, and incompatible chemicals
Hygiene: Wash hands thoroughly after handling; never eat or drink in storage or work areas
Engineering Controls: Use fume hood or local exhaust ventilation
Respiratory Protection: Dust mask or NIOSH-approved respirator if airborne dust anticipated
Skin Protection: Chemically resistant gloves and long sleeves
Eye Protection: Safety goggles or face shield
Other Protective Measures: Lab coat, closed footwear; emergency shower and eyewash station nearby
Appearance: White to yellowish crystalline powder
Odor: Odorless or faintly characteristic
pH: Not applicable (insoluble in water; soluble in organic solvents)
Melting Point: 147–150°C (lit.)
Boiling Point: Decomposes
Solubility: Moderately soluble in methanol, ethanol, chloroform; very slightly soluble in water
Vapor Pressure: Negligible at room temperature
Partition Coefficient (Log Kow): Unavailable
Density: Approximately 1.4 g/cm³
Evaporation Rate: Not applicable
Stability: Stable under normal temperatures and pressures
Conditions to Avoid: Moisture, heat, direct sunlight, open flames
Incompatible Materials: Strong oxidizers, strong acids
Hazardous Decomposition: May release carbon and nitrogen oxides, toxic vapors when heated or decomposed
Polymerization: Not anticipated under standard handling conditions
Acute Toxicity: Oral LD50 in rodent models exceeds 2000 mg/kg; low acute toxicity
Chronic Effects: Headache, hypotension, nausea, and potential CNS effects reported at high doses based on clinical pharmacology
Skin, Eye, and Respiratory Irritation: Irritation likely with direct exposure
Carcinogenicity: No evidence of carcinogenicity in available animal studies; compound not listed by IARC, NTP, OSHA
Mutagenicity and Teratogenicity: No evidence found in standard lab models; not considered genotoxic
Target Organs: Central nervous system, liver at significantly elevated exposure levels
Ecotoxicity: Lack of standard test data; similar ergoline compounds suggest low environmental persistence and bioaccumulation
Mobility in Soil: Expected low mobility due to low water solubility
Persistence and Degradability: No significant persistence; likely to degrade through natural processes
Bioaccumulative Potential: Not expected to bioaccumulate
Other Adverse Effects: No evidence for environmental hazard in small-scale use
Waste Treatment Methods: Dispose of through licensed waste contractor or hazardous waste incineration
Product Disposal: Treat as pharmaceutical or laboratory hazardous waste; do not flush into drains
Contaminated Packaging: Dispose of as hazardous solid waste after neutralization if feasible
Regulatory Considerations: Follow local, national, and international regulations for pharmaceutical waste
UN Number: Not regulated for ground, air, or sea transport under UN, IATA, DOT, IMDG
Proper Shipping Name: Not assigned
Transport Hazard Class: Non-hazardous
Packing Group: Not applicable
Marine Pollutant: No data suggesting hazard
Special Precautions: Protect from excessive heat and physical damage during transport
Labeling Requirements: Pharmaceutical/intermediate labeling applies; not classified as hazardous for industrial handling
TSCA: Not listed
REACH Status: Subject to registration if used over threshold in EU
OSHA: Not considered hazardous under OSHA Hazard Communication Standard
WHMIS Classification: Not controlled
SARA Title III: Not listed as extremely hazardous
Other International Controls: Check national registries for pharmaceutical ingredients and workplace safety regulations
