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Product Name: Nicarbazin
Chemical Name: 4,4’-Dinitrocarbanilide and 2-hydroxy-4,6-dimethylpyrimidine
CAS Number: 330-95-0
Synonyms: DNC–HDP Complex
Recommended Use: Antiprotozoal feed additive, strictly for veterinary use, controls coccidiosis in poultry
Supplier: Contact animal health or feed supplier for manufacturer details
Emergency Telephone Number: Local poison control center or supplier-provided contact
Classification: Available studies classify Nicarbazin as not acutely toxic by oral, dermal, or inhalation exposure, falling outside the GHS acute toxicity category; not considered corrosive or an irritant.
Label Elements: Not classified as dangerous according to GHS; precautionary statements for dust inhalation risk.
Hazards: Dust can irritate respiratory system and eyes. Spilled material on skin may cause mild irritation in sensitive individuals.
Health Effects: Swallowing large amounts can disrupt egg production and cause health effects in birds but rarely affects humans at typical exposure levels.
Environmental Risks: Water contamination with large amounts can impact aquatic life.
Active Ingredient: Nicarbazin (99% purity typically found in technical grade products)
Chemical Formula: C19H18N6O6 for dinitrocarbanilide; C6H8N2O2 for 2-hydroxy-4,6-dimethylpyrimidine
Impurities: Trace levels of process-related impurities, not reported to be hazardous at concentrations present.
Formulation Components: In commercial products may contain starch, calcium carbonate, or other feed carriers.
Inhalation: Move affected individual to fresh air. Consider seeking medical attention if irritation occurs or persists.
Eye Contact: Rinse under gentle running water for at least fifteen minutes, keeping eyelids open. Medical help for persistent discomfort.
Skin Contact: Remove contaminated clothing; wash skin with mild soap and water. See a physician if symptoms develop.
Ingestion: Rinse mouth thoroughly, seek medical advice. Never give anything by mouth to an unconscious person.
Advice for Physicians: Treat symptomatically; no specific antidote exists.
Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide. Water jet may spread dust and should be avoided.
Combustion Hazards: Toxic fumes such as nitrogen oxides and carbon oxides may form if product burns.
Personal Protection: Wear self-contained breathing apparatus and full protective gear.
Special Procedures: Prevent run-off water from contaminating watercourses or sewers.
Personal Protection: Avoid breathing dust; use dust mask and gloves. Ventilate area for large spills.
Environmental Precautions: Prevent entry to rivers, drains, or soil. Use absorbent earth for containment of bulk material.
Cleaning Method: Sweep or scoop up spilt material into dust-tight labeled containers for disposal. Wash contaminated area with water.
Safe Handling: Use protective gloves and safety glasses. Avoid generating dust clouds. Wash hands after handling.
Storage Conditions: Store in original, tightly closed containers in a cool, dry, well-ventilated space away from feed and foodstuffs.
Storage Temperature: Keep away from heat, direct sunlight, or moisture to preserve stability.
Incompatible Substances: Strong oxidizers or acids could cause degradation.
Exposure Limits: No established occupational exposure limits specifically for Nicarbazin; keep dust concentrations as low as possible.
Engineering Controls: Employ good general ventilation; local exhaust recommended for bulk handling.
Protection: Safety goggles, dust mask (nuisance level), gloves made from non-reactive materials.
Hygiene: Avoid touching face or eating while handling. Wash thoroughly after use.
Appearance: Off-white to yellowish-gray powder
Odor: Odorless or faint chemical smell
pH: 5.5–7.0 (aqueous suspension)
Melting Point: Dinitrocarbanilide component melts at approximately 220°C; HDP component at 220–225°C
Solubility: Practically insoluble in water; slightly soluble in organic solvents like ethanol or acetone
Vapor Pressure: Negligible, does not evaporate
Density: Around 1.44 g/cm³
Partition Coefficient (log Kow): 2.23 (dinitrocarbanilide), -0.14 (HDP)
Chemical Stability: Stable under normal storage and handling conditions.
Conditions to Avoid: Exposure to extreme heat, direct sunlight, moisture.
Incompatible Materials: Strong acids, bases, and oxidizers.
Decomposition Products: On burning, may release nitrogen oxides, carbon oxides, and toxic particles.
Hazardous Reactions: No dangerous reactions reported under normal conditions of use.
Acute Toxicity: Oral LD50 >10,000 mg/kg (rat). Low toxicity by single-dose exposure.
Skin and Eye Contact: Mild irritation possible if large quantities come in contact with sensitive skin or eyes.
Long-term Effects: Prolonged, repeated exposure unlikely to cause harm in humans at normal occupational levels. Very high doses shown to inhibit egg production and cause reproductive issues in birds.
Cancer Risk: No conclusive evidence of carcinogenicity identified.
Mutagenicity: Not found mutagenic or genotoxic in studies conducted to date.
Sensitization: Low potential for allergic reactions in humans.
Environmental Fate: After use in animals, much is excreted unchanged or as low-toxicity metabolites.
Aquatic Toxicity: Toxic to aquatic invertebrates and fish in laboratory studies at elevated concentrations.
Persistence and Degradability: Tends to persist in soil and water; not quickly broken down by microbes or sunlight.
Bioaccumulation: Low to moderate potential; does not strongly accumulate in animal tissues.
Soil Mobility: Moderately mobile; risk of groundwater contamination is present if improperly managed.
Waste Treatment: Avoid discharge into sewers or the environment. Collect all residues or waste material, seal in labeled, disposable containers.
Methods: Disposal at authorized chemical or pharmaceutical waste facilities. Do not burn, crush, or attempt to compost.
Container Disposal: Rinse thoroughly, comply with local hazardous waste guidelines.
UN Number: Not classified as hazardous for transport.
Proper Shipping Name: Nicarbazin
Transport Hazard Class: Not regulated in major jurisdictions.
Packing Group: None assigned.
Special Precautions: Prevent container damage or leaks; shield from extreme heat and moisture during transit.
Labeling: Not classified as hazardous material under current United States OSHA, European CLP, or Globally Harmonised System (GHS) guidelines.
Veterinary Regulations: Only approved for use in selected countries as a coccidiostat feed additive for poultry.
Residue Monitoring: Subject to regulatory maximum residue limits (MRLs) in countries where approved for food-producing animals.
Worker Protections: Adhere to feed mill hygiene rules and worker safety practices.
Other Standards: May be listed under chemical inventories such as TSCA, REACH, or similar country-specific lists.
