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Product Name: Neomycin B Sulfate also known as Framycetin Sulfate
Synonyms: Neomycin Sulfate, Neomycin B, Framycetin
CAS Number: 1405-10-3
Recommended Use: Antibacterial ingredient in pharmaceuticals, topical creams, wound ointments
Manufacturer/Supplier: Refer to product label or invoice
Contact Information: Emergency phone numbers available from supplier or local poison control center
GHS Classification: Harmful if swallowed (Acute Toxicity: Oral, Category 4), Causes skin irritation (Skin Irritation: Category 2), Causes serious eye irritation (Eye Irritation: Category 2A), May cause allergic skin reaction (Sensitization: Category 1)
Label Elements: Warning pictogram (exclamation mark), Signal word: Warning
Hazard Statements: May cause irritation to skin, eyes, and respiratory tract; possible allergic reactions; risk of hearing loss with high or prolonged exposure or ingestion; toxic to aquatic organisms
Precautionary Statements: Avoid breathing dust, wear protective gloves and eye protection, do not eat, drink, or smoke during use
Chemical Name: Neomycin B Sulfate / Framycetin Sulfate
Formula: C23H46N6O13 • 2H2SO4
Content: >95% purity
Impurities: Neomycin C, other aminoglycoside compounds trace levels
Additives: No intentional ingredients other than active substance
Inhalation: Move to fresh air, keep at rest, seek medical help if irritation or symptoms persist
Skin Contact: Wash off with soap and water for several minutes, remove contaminated clothing, get medical advice if skin reaction appears
Eye Contact: Rinse gently with clean water for at least 15 minutes, remove contact lenses if present and easy to do, call a physician if discomfort continues
Ingestion: Rinse mouth with water, do not induce vomiting, consult a medical professional immediately; risk of serious adverse effects
Most Important Symptoms: Rash, redness, sneezing, wheezing, possible hearing issues after repeated exposure
Immediate Medical Attention Needed: For breathing problems, severe allergic reaction, hearing changes
Suitable Extinguishing Media: Water spray, dry chemical, foam, CO2
Unsuitable Extinguishing Media: No known restrictions, but water jet may spread spill
Specific Hazards: Emits toxic fumes under fire conditions (nitrogen oxides, sulfur oxides)
Protective Equipment: Full protective gear and self-contained breathing apparatus for firefighters
Firefighting Procedures: Evacuate area, use water spray to cool containers, avoid breathing smoke, prevent chemical runoff into drains
Personal Precautions: Wear gloves, goggles, mask; avoid dust formation; ventilate area
Environmental Precautions: Keep away from surface water and drains; minimize environmental contamination as compound shows toxicity to aquatic life
Containment Methods: Sweep up without creating dust, shovel into appropriate waste container for disposal
Cleanup Procedures: Wash affected area with water and detergent; dispose of cleaning water safely
Safe Handling: Use in well-ventilated spaces; avoid breathing dust or contact with skin/eyes; wear appropriate protective gear; avoid eating or drinking while handling
Storage Conditions: Store in cool, dry, well-ventilated location away from sunlight and incompatible substances like acids, strong oxidizers, alkalis
Incompatibilities: Keep away from reactive chemicals; do not mix with cleaning chemicals not approved by supplier
Inventory Management: Keep container tightly sealed, check labels and material integrity regularly
Engineering Controls: Mechanical exhaust ventilation recommended, fume hoods where applicable, eyewash stations
Personal Protective Equipment (PPE): Chemical safety goggles, impermeable gloves (nitrile or PVC), lab coat or apron, dust mask or respirator (NIOSH approved) in areas with dust
Exposure Limits: No OSHA, ACGIH or EU exposure limits set, but minimize prolonged or repeated exposure by following safety practices
Hygiene Measures: Handwashing after handling, regular laundering of protective gear, do not reuse contaminated clothing
Appearance: White or almost white powder
Odor: Slight, sometimes odorless
pH (1% solution): 5.0–7.5
Melting Point: Decomposes on heating, does not show sharp melting point
Solubility: Very soluble in water, practically insoluble in organic solvents like ethanol and chloroform
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Not applicable
Flash Point: Not relevant (not flammable under normal conditions)
Stability: Stable under normal storage, sensitive to strong oxidizing/reducing agents
Chemical Stability: Stable when stored in original container under proper conditions
Conditions to Avoid: Excessive heat, light, moisture, strong acids and bases, oxidizing agents
Hazardous Reactions: May form toxic compounds on thermal decomposition (NOx, SOx); no violent reactions documented under routine conditions
Decomposition Products: Nitrogen oxides, sulfur oxides upon combustion
Polymerization: No hazardous polymerization expected
Acute Toxicity: Oral LD50 (rat) more than 2000 mg/kg
Chronic Exposure: Risk of ototoxicity (hearing damage), nephrotoxicity (kidney injury) with repeated occupational or medicinal exposure
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Skin rashes, eye irritation, nausea, vomiting, loss of appetite, respiratory irritation
Sensitization: Reports of allergic reactions including anaphylactic shock, especially in pre-sensitized people
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Genotoxicity: No convincing evidence from available studies
Reproductive Toxicity: No clear risks identified in available reports
Ecotoxicity: Toxic to aquatic organisms, LC50 values (fish/daphnia) at low mg/L concentrations, risk of long-term adverse effects in aquatic environments
Persistence and Degradability: Bioactive compound, not easily degradable in wastewater systems
Bioaccumulative Potential: Does not show significant bioaccumulation in wildlife, but can harm beneficial bacteria and aquatic microbiota
Mobility in Soil: Water solubility increases mobility, risk of groundwater contamination
Other Adverse Effects: May upset balance in aquatic ecosystems, resist breakdown by conventional sewage treatment
Waste Disposal Methods: Dispose of as hazardous waste following local/national regulations; incineration under controlled conditions preferred
Contaminated Packaging: Triple rinse, dispose of as hazardous material
Environmental Precautions: Do not flush into drains, water bodies, or sewage systems
Reuse/Recycling: Not recommended due to residual bioactivity
Further Information: Contact waste disposal contractor for advice if in doubt
UN Number: Not assigned specific UN number; not classified as dangerous goods under international transport regulations
Proper Shipping Name: Neomycin B Sulfate/Framycetin Sulfate
Hazard Class: Not regulated for transport
Packing Group: Not regulated
Environmental Hazards: Substance can be dangerous for the environment, avoid uncontrolled release
Special Precautions: Transport in tightly closed containers, avoid physical damage or moisture exposure
Classification under Chemical Legislation: Controlled substance in many countries; pharmaceutical/industrial use only
Safety, Health, Environmental Regulations: Compliance with OSHA, EU REACH, EPA and local regulations; handling in accordance with workplace safety protocols
Labeling Requirements: Must use GHS symbols and warnings throughout distribution chain
Workplace Controls: Maintain proper record-keeping, provide training for handlers and first responders
Additional Notes: Prescription drug status in many nations; use only by qualified personnel with appropriate prescription or industrial need
