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Product Name: Nefiracetam
Synonyms: DM-9384, N-(2,6-Dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide
Chemical Formula: C14H18N2O2
Molecular Weight: 246.31 g/mol
CAS Number: 77191-36-7
Intended Use: Research, pharmaceutical research, cognitive enhancement studies
Contact Information: Manufacturer or supplier details should be printed on label or shipping documentation; emergency information may be accessed through local poison control or regulatory authorities.
Classification: Not classified under GHS for most typical use scenarios; long-term health effects data is limited; may cause respiratory and eye irritation if inhaled or if dust is generated.
Label Elements: No pictogram or signal word specified by OSHA; avoid inhalation, ingestion, and direct contact.
Hazards: Mild eye, skin, or respiratory irritation possible; untested for carcinogenicity or reproductive toxicity.
Routes of Exposure: Inhalation, ingestion, dermal contact.
Precautionary Statements: Use in well-ventilated area, employ personal protective equipment, prevent environmental release.
Chemical Name: Nefiracetam
Concentration: 98%+ purity (may vary by supplier batch)
Impurities: Minor synthetic by-products, identified through Certificate of Analysis on request
Form: White to off-white crystalline powder
Other Additives: None known for reagent-grade material; check supplier safety documentation for excipients in formulated products.
Eye Contact: Rinse thoroughly with water for several minutes; remove contact lenses if present and easy to do.
Skin Contact: Wash area with soap and plenty of water; seek medical attention for persistent irritation.
Inhalation: Move victim to fresh air; perform artificial respiration if breathing stops; seek medical assistance.
Ingestion: Rinse mouth with water, seek medical attention; do not induce vomiting unless instructed by healthcare professional.
Advice for Physicians: Treat symptomatically; no known antidote; monitor vital signs and provide supportive care.
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray.
Specific Hazards: Combustion may generate toxic fumes such as nitrogen oxides, carbon monoxide, carbon dioxide.
Protective Equipment: Firefighters should use self-contained breathing apparatus and protective suit.
Firefighting Procedures: Move containers from fire area if safe, avoid inhalation of smoke or fumes, use water spray to keep unopened containers cool.
Explosion Data: No data on explosive properties; treat as combustible organic solid.
Personal Precautions: Wear gloves, lab coat, dust mask, and goggles; avoid breathing dust.
Environmental Precautions: Prevent runoff into drains, watercourses, or soil.
Cleanup Procedures: Sweep or scoop spilled material using non-sparking tools; place in labeled, sealed container for disposal.
Decontamination: Wash spill area with detergent and water after initial cleanup.
Waste Handling: Dispose of as hazardous chemical waste according to local regulations.
Handling: Work in chemical fume hood or well-ventilated area; minimize dust generation; keep containers tightly closed.
Personal Hygiene: Avoid eating, drinking, or smoking in area of use; wash hands after handling.
Storage: Store in tightly sealed original container in a cool, dry place; keep away from heat sources, direct sunlight, and incompatible chemicals.
Incompatible Materials: Strong oxidizing agents, acids.
Special Considerations: Dedicated storage space, avoid contamination with other materials.
Occupational Exposure Limits: No occupational exposure limits established by OSHA, ACGIH, or NIOSH for nefiracetam.
Engineering Controls: Work under fume hood, use local exhaust ventilation.
Personal Protection: Nitrile or latex gloves, chemical safety goggles, lab coat, dust mask or respirator in case of powder handling.
Hygiene Measures: Wash hands and face thoroughly after handling; avoid direct skin or eye contact.
Appearance: White to off-white crystalline powder.
Odor: Odorless or very faint odor.
Melting Point: Approximately 128–130°C.
Boiling Point: Data unavailable; decomposes before boiling.
Solubility: Soluble in ethanol and DMSO, limited solubility in water.
Vapor Pressure: Not measured; assumed very low at room temperature.
pH: Not applicable (solid form).
Partition Coefficient (log P): 0.8 (estimated).
Stability: Stable under recommended handling and storage.
Chemical Stability: Stable at room temperature, sensitive to heat and light.
Incompatible Materials: Avoid strong acids, strong bases, oxidizing agents.
Decomposition Products: Thermal decomposition can produce hazardous gases such as carbon monoxide, carbon dioxide, nitrogen oxides.
Hazardous Polymerization: Not known to occur under standard conditions.
Conditions to Avoid: Exposure to heat, moisture, and direct sunlight.
Acute Toxicity: Detailed human LD50 data unavailable; animal studies show low to moderate oral toxicity.
Chronic Toxicity: Long-term effects in humans are not established.
Routes of Exposure: Possible through inhalation, ingestion, dermal or ocular contact.
Potential Health Effects: May cause mild to moderate irritation to eyes and mucous membranes; no reported sensitization.
Carcinogenicity/Mutagenicity: Not classified by IARC, NTP, or OSHA.
Reproductive Toxicity: No conclusive data.
Medical Conditions Aggravated: Unknown; exercise caution with impaired liver or renal function.
Ecotoxicity: No specific studies available; structural analogues show low aquatic toxicity.
Persistence and Degradability: Not readily biodegradable in standard tests; potential for slow breakdown in environment.
Bioaccumulation Potential: Expected to be low based on physicochemical properties.
Mobility in Soil: Limited data; likely low due to solubility and partition coefficient.
Other Adverse Effects: Prevent release to waterways, sewers, or soil to reduce environmental exposure.
Disposal Methods: Collect and send to licensed chemical waste disposal facility.
Container Disposal: Triple rinse empty containers with water and detergent, puncture and dispose according to regulatory requirements.
Environmental Precaution: Do not dispose in household garbage, surface water, or public sewage systems.
Waste Codes: Follow local, regional, and national regulations for disposal of laboratory and pharmaceutical chemicals.
UN Number: Not assigned.
Proper Shipping Name: Research chemical, not regulated for transportation by road, air, or sea in most jurisdictions.
Hazard Class: Not assigned.
Packing Group: Not assigned.
Special Precautions: Pack to prevent spillage or dust emission; include safety data sheets and emergency contact with shipment.
OSHA Hazards: Not listed as hazardous under US Federal OSHA standards.
TSCA Status: Not listed on US TSCA Inventory due to research chemical exemption.
REACH Status: Not registered under EU REACH; limited for research and development use.
SARA Title III: Not listed as a reportable substance.
DSL/NDSL Status (Canada): Not present on domestic substances list.
Other International Regulations: Not classified as controlled, though import and research restrictions may apply.
Labelling: Research use only, not for human or veterinary drug, food, or household use unless specifically authorized by appropriate regulatory agencies.
