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Product Name: Narasin Sodium
Chemical Family: Polyether Ionophore Antibiotic
Chemical Formula: C43H71NaO11
CAS Number: 132941-54-7
Intended Use: Animal feed additive for coccidiosis prevention
Manufacturer: Specify manufacture contact information, address, and emergency contact numbers for rapid communication in case of incidents
Synonyms: Listed as 4'-[[2,6-dideoxy-3-C-methyl-3-O-methyl-β-D-ribo-hexopyranosyl]oxy]-2,3,5,6,7,13,15,17-octamethyl-10,21-dioxaheptacyclo[16.2.1.13,6.18,11.02,17.013,15.020,22]docosane-9,18,19-trione sodium salt
Recommended Restrictions: Use only as directed by animal health professionals; intended for veterinary and agricultural settings
Classification: Acute toxicity (oral, dermal, inhalation), hazardous to aquatic environment, specific target organ toxicity
GHS Label Elements: Signal word DANGER, hazard pictograms for toxic and long-term health effects, exclamation mark for irritation
Hazard Statements: Toxic if swallowed, skin contact may cause irritation, suspected of causing genetic defects, may damage fertility or the unborn child, very toxic to aquatic organisms with lasting effects
Precautionary Statements: Avoid breathing dust, wear gloves and protective clothing, wash thoroughly after handling, avoid release into the environment, seek medical advice if symptoms occur
Other Hazards: Ingestion in non-target species including horses and dogs can be fatal, environmental persistence requires careful control to prevent contamination outside controlled areas
Chemical Name: Narasin Sodium
Concentration: 90%–98% active ingredient typically
Impurities: Trace secondary fermentation products, residual solvents below regulatory limits
Other Ingredients: Inert carriers or bulking agents used for formulation, including mineral mixtures or starch, depending on product
Chemical Abstracts Service (CAS) No.: 132941-54-7
EC Number: N/A
Relevant Exposure Limits: No official occupational exposure limit values established; limit handling time and use engineering controls
Inhalation: Remove to fresh air, monitor for respiratory difficulty, seek medical attention if symptoms persist, provide oxygen if breathing is labored
Skin Contact: Remove contaminated clothing and rinse skin thoroughly with soap and water, seek medical advice if irritation develops or persists
Eye Contact: Rinse eyes gently with water for several minutes, remove contact lenses if present, continue rinsing, consult eye specialist for persistent symptoms
Ingestion: Rinse mouth, never induce vomiting unless instructed by a physician, seek immediate medical assistance; symptoms may be delayed
Most Important Symptoms and Effects: Gastrointestinal discomfort, headache, muscle weakness, potential cardiac or neurological effects with significant exposure
Suitable Extinguishing Media: Dry chemical, CO₂, foam, apply water spray to cool exposed containers
Unsuitable Extinguishing Media: Avoid high-pressure water streams as they may spread material
Specific Hazards: Emits toxic fumes—carbon monoxide, carbon dioxide, sodium oxides—on combustion, dust in suspension can ignite under certain circumstances
Protective Equipment: Wear self-contained breathing apparatus, full protective gear
Special Procedures: Limit water runoff to prevent environmental contamination
Personal Precautions: Wear protective clothing, gloves, and respiratory protection to avoid contact with skin and inhalation of dust
Environmental Precautions: Prevent entry into waterways, drains, or soil; contain spill using earth, sand, or inert material
Cleanup Methods: Sweep carefully to prevent dust generation, collect in designated containers for disposal, ventilate area, clean surfaces thoroughly with water and detergent
Reference to Other Sections: Consult handling, disposal, and personal protection guidance
Safe Handling Practices: Avoid dust formation, use in well-ventilated areas, prevent exposure to skin or eyes during mixing or weighing, avoid eating or smoking during use
Storage Conditions: Store in tightly closed original containers in a dry, cool, well-ventilated place away from incompatible substances, especially acids and oxidizers
Incompatible Materials: Strong acids, strong oxidizers, moisture
Specific Storage Requirements: Keep away from animal feed not intended for monogastric animals, segregate from areas accessible to children and unauthorized persons
Engineering Controls: Local exhaust ventilation, closed handling systems, dust extraction equipment
Personal Protective Equipment: Impervious gloves, long-sleeved coveralls, chemical splash goggles or safety glasses, certified respirators for airborne particles
Hygiene Measures: Wash hands, arms, and face after handling, launder contaminated clothing, avoid cross-contamination in food and drink areas
Occupational Exposure Limits: No established values; reduce exposure as low as practical using engineering and administrative controls
Appearance: White to off-white crystalline powder
Odor: Faint, musty
Odor Threshold: Not established
pH: 7–8 (1% solution)
Melting Point: Not applicable (decomposes before melting)
Boiling Point: Not applicable (decomposition)
Flash Point: Data not available due to decomposition on heating
Evaporation Rate: Not volatile under ambient conditions
Flammability: Dust may form explosive mixtures with air
Vapor Pressure: Negligible at room temperature
Solubility: Slightly soluble in water, freely soluble in methanol, ethanol, and chloroform
Partition Coefficient (log Kow): Not available
Relative Density: Approx. 1.3–1.4 g/cm³
Viscosity: Not applicable (solid powder)
Other Properties: Hygroscopic, stable under normal conditions if protected from moisture and light
Stability: Stable under normal storage and use conditions
Hazardous Reactions: Reacts with strong acids and oxidizers forming hazardous decomposition products
Decomposition Products: Toxic fumes, including sodium oxides, carbon monoxide, carbon dioxide
Conditions to Avoid: Excessive heat, moisture, direct sunlight
Polymerization: Not expected to occur
Reactivity: Not reactive under recommended storage and use conditions
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Oral LD50 (rat): approximately 27 mg/kg, significantly lower in non-target species
Chronic Effects: Nervous system effects, potential cardiac irregularities, muscle tremors
Skin and Eye Irritation: Moderate skin and eye irritant
Mutagenicity / Carcinogenicity: Data do not show clear evidence of carcinogenic potential, but genetic toxicity cannot be ruled out due to mechanism of action
Reproductive Toxicity: Animal studies indicate reproductive and developmental effects at high exposures
Target Organ Effects: Neuromuscular, cardiac, hepatic impacts observed at high doses
Sensitization: Not a known skin sensitizer under standard test conditions
Other Data: Fatal to horses and some monogastric species at low doses; keep strictly separated from these animals
Environmental Fate: Persistent in soils, risk of groundwater contamination if spilled
Ecotoxicity: Very toxic to sediment-dwelling invertebrates and aquatic organisms, especially crustaceans, acute LC50 for Daphnia: low μg/L range
Bioaccumulation Potential: Moderate, potential for accumulation in aquatic organisms
Degradation: Slow natural breakdown, photodegradation contributes to environmental decay though not rapid under all conditions
Mobility in Soil: Moderate mobility, greatest risk in sandy, low-organic soils
Other Harmful Effects: Harmful effect on non-target soil microorganisms, possible indirect effects on soil fertility
Waste Treatment Methods: Incinerate in approved facility, do not discharge to drains, watercourses, or soil
Disposal of Product: Treat as hazardous chemical waste, comply with national and local regulations
Disposal of Packaging: Triple rinse empty containers, puncture and dispose in accordance with local hazardous waste guidelines, do not reuse packaging for food or animal feed
Environmental Precautions: Prevent contamination of water sources long-term by maintaining strict control on waste and contaminated cleaning fluids
UN Number: Not classified as dangerous goods for transport under most jurisdictions, but specific requirements applicable if shipped in bulk
Proper Shipping Name: Narasin Sodium or antibiotic preparation (solid)
Transport Hazard Class: Not regulated as a hazardous material under UN Recommendations but local rules may vary
Packing Group: Not assigned
Environmental Hazards: Classified as environmentally hazardous substance for shipment over water
Special Precautions: Avoid release to environment during loading/unloading, ensure containers are unbroken and dry, apply additional labeling for marine shipments
Global Inventories: Narasin sodium may not appear on general chemical inventories but is controlled for use as an animal feed additive across regions
Regulations: Covered by veterinary medicines regulations, maximum allowable levels set for feed premixes, restricted use enforced by animal health authorities
Environmental Regulations: Subject to restrictions based on local aquatic toxicity and persistence, reporting requirements for accidental releases to water or soil
Worker Safety Laws: Jurisdictions require training and worker access to MSDS and personal protective gear
Labeling Requirements: Clear labeling for veterinary use only, hazard warnings, and poison control contact information mandatory on packaging
Additional Controls: Strict transport, storage, and record-keeping requirements for purchase and use, especially in jurisdictions concerned about growth promoter misuse and environmental impact
