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Product Name: Nalidixic Acid
Chemical Formula: C12H12N2O3
CAS Number: 389-08-2
Synonyms: 1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
Manufacturer: Refer to packaging or supplier details
Recommended Uses: Antibiotic compound, laboratory research
Contact Information: Emergency telephone numbers and address as provided by supplier
Classification: Harmful if swallowed or inhaled; may cause irritation to skin, eyes, and respiratory tract
GHS Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Hazard Statements: May harm if mishandled; causes serious eye irritation; suspected of damaging fertility or an unborn child; risk of skin and respiratory irritation
Precautionary Statements: Wear protective gloves, avoid breathing dust, wash hands thoroughly after handling, do not eat, drink, or smoke when using this chemical
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Potential Environmental Effects: Can be toxic to aquatic organisms upon release
Chemical Name: Nalidixic Acid
Concentration: Greater than 98% pure
Impurities: Remainder consists of trace organic solvents or process residues
Molecular Weight: 250.24 g/mol
Relevant Ingredients: No additional hazardous components reported; single-ingredient substance
EC Number: 206-864-7
Inhalation: Move exposed person to fresh air; give oxygen if breathing becomes difficult; seek prompt medical care
Skin Contact: Remove contaminated clothing; wash skin with soap and water for at least 15 minutes; consult physician if irritation develops
Eye Contact: Rinse eyes with large amounts of water for 15 minutes, lifting upper and lower lids occasionally; seek immediate medical attention
Ingestion: Rinse mouth with water if conscious; never attempt to give anything by mouth to an unconscious person; obtain medical attention
Most Important Symptoms: Risk of headache, nausea, vomiting, dizziness, severe irritation to mucous membranes
Notes to Physician: Consider symptomatic and supportive management; monitor for possible allergic reactions or neurological effects
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide to extinguish fires involving this substance
Specific Hazards: Dust may form explosive mixture with air; thermal decomposition can release hazardous gases like nitrogen oxides and carbon oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus and complete protective clothing
Special Procedures: Stay upwind, contain runoff from firefighting efforts to prevent contamination of watershed
Hazardous Combustion Products: Produces toxic fumes of nitrogen, carbon monoxide, and carbon dioxide during combustion
Personal Precautions: Wear appropriate respiratory protection, gloves, goggles, and lab coat; avoid dust formation
Emergency Procedures: Evacuate unnecessary personnel; ventilate area
Methods for Clean Up: Sweep up, avoiding dust generation; place in labeled, suitable, closed containers for proper disposal; wash spill site after pickup
Environmental Precautions: Prevent entry into soil, drains, surface water or groundwater; inform environmental authorities if contamination risk arises
Precautions for Handling: Only handle in well-ventilated areas; avoid forming dust; wear suitable protective equipment at all times; practice good hygiene by washing hands after handling
Storage Conditions: Store locked up, away from incompatible materials such as strong oxidizers or acids; keep container tightly closed in a cool, dry place, and out of direct sunlight
Incompatibilities: Keep separate from bases and reducing agents; avoid moisture exposure
Storage Temperature: Typically between 2°C and 8°C, protected from light
Occupational Exposure Limits: No specific national or international limits, but minimize exposure following good laboratory practices
Engineering Controls: Use fume hood or local exhaust for dust control
Personal Protective Equipment: Chemical goggles, nitrile gloves, protective clothing, approved particulate respirator
Hygiene Measures: Remove contaminated clothing; wash hands and face after use; do not eat, drink, or smoke in work area
Environmental Controls: Prevent release into environment; use closed systems if possible
Appearance: White to light yellow crystalline powder
Odor: Odorless
pH: 2.1 - 2.7 (1% solution in water)
Melting Point: Approximately 225°C with decomposition
Boiling Point: Data not applicable due to decomposition
Solubility: Poorly soluble in water (less than 1 mg/mL); more soluble in alkaline solutions and some organic solvents
Vapor Pressure: Not significant at room temperature
Flash Point: Not established; unlikely to pose significant fire risk under normal conditions
Density: About 1.56 g/cm³
Partition Coefficient (log Kow): Approximately 0.33
Other Properties: Stable under normal laboratory conditions in absence of incompatible chemicals
Reactivity: Relatively stable under intended storage and handling conditions
Chemical Stability: Maintains integrity in dry, cool, and protected environment
Possible Hazardous Reactions: Risk of hazardous decomposition with heat, strong oxidizers, or acids; dust accumulation may result in explosion risk under certain conditions
Incompatible Materials: Strong oxidizing agents, strong bases, reducing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, and possibly toxic organic fumes
Acute Toxicity Data: Oral LD50 (rat): approximately 4000 mg/kg; inhalation and dermal LD50 not well established but expected to be high
Short-Term Exposure Symptoms: Headache, nausea, abdominal discomfort, skin or eye irritation
Chronic Effects: Can affect central nervous system and kidneys with long-term or repeated exposure; may trigger allergic reactions in sensitized individuals
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Reproductive Toxicity: Suspected risk based on some animal studies; inadequate evidence in humans, but always practice caution
Other Noted Effects: Large accidental exposures may trigger seizures, especially in predisposed individuals
Persistence and Degradability: May persist for weeks to months in aquatic and terrestrial environments; resists rapid biodegradation
Bioaccumulation Potential: Low due to limited solubility and rapid excretion in higher organisms
Ecotoxicity: Toxic to fish and microorganisms at elevated concentrations; may cause long-lasting adverse effects in aquatic environments
Mobility in Soil: Moderate to low, binds to organic matter
Other Adverse Effects: Not expected to evaporate or significantly volatilize into atmosphere
Disposal Methods: Chemically contaminated waste must be disposed of in compliance with local, national, and federal regulations; do not allow material to enter water systems or public sewers
Recommended Disposal Procedures: Incineration under controlled conditions in authorized facility; triple rinse containers before disposal
Packaging Disposal: Destroy empty containers to prevent reuse; follow guidelines for hazardous laboratory chemical packaging
UN Number: Not allocated for non-bulk transportation
Transport Hazard Classification: Not regulated as dangerous good under IATA, IMDG, or ADR for this material in expected quantities
Packing Group: Not applicable
Shipping Name: Nalidixic Acid, solid
Special Precautions: Package tightly; protect from physical damage and sources of ignition during transit
Environmental Hazards: Mark as hazardous to environment if shipped in larger amounts
Safety, Health, Environmental Regulations: Listed under local chemical inventories such as TSCA (US), DSL (Canada), and EU REACH
Labelling Requirements: GHS-compliant labeling with signal word, hazard pictograms, and precautionary statements mandatory for distribution
Restrictions: Some jurisdictions restrict medicinal use, requiring prescription and dispensing only through authorized professionals
Other Applicable Laws: Waste disposal regulated under hazardous waste laws; occupational exposure governed by workplace safety acts as applicable in region of use
