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Product Name: Nafamostat Methanesulfonate
Chemical Formula: C21H25N5O7S2
CAS Number: 82956-11-4
Synonyms: Nafamostat mesylate, FUT-175
Intended Use: Laboratory research, pharmaceutical ingredient
Manufacturer Identification: Refer to supplied invoice or package labeling for manufacturer’s contact details.
Emergency Phone Number: Please refer to supply source documentation specific to your country.
GHS Classification: Acute toxicity (Oral, Category 3), Skin irritation (Category 2), Eye irritation (Category 2A), Aquatic chronic (Category 2)
Signal Word: Danger
Hazard Statements: Harmful if swallowed, Causes skin and eye irritation, Hazardous to aquatic life with long lasting effects.
Pictograms: Skull and crossbones, Exclamation mark, Environment
Precautionary Statements: Do not breathe dust or mists, wash hands thoroughly after handling, avoid release to environment, wear protective gloves/eyes/face protection.
Chemical Name: Nafamostat Methanesulfonate
Concentration: 98–100%
CAS Number: 82956-11-4
Impurities or Additives: Not present above detection threshold
Molecular Weight: 539.58 g/mol
Inhalation: Move person to fresh air, provide oxygen if breathing is difficult. Seek medical attention immediately.
Skin Contact: Remove contaminated clothing. Rinse skin thoroughly with water. Wash with soap. Obtain medical advice if irritation continues.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses. Get medical attention for persistent discomfort.
Ingestion: Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth. Seek immediate medical help.
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical, or alcohol-resistant foam.
Specific Hazards Arising from the Chemical: Emits toxic fumes under fire conditions (nitrogen oxides, sulfur oxides, carbon oxides).
Protective Equipment: Firefighters use self-contained breathing apparatus and pants, gloves, eye protection.
Firefighting Instructions: Remove containers from danger if possible. Use water mist to cool unopened containers. Avoid inhalation of smoke or gases.
Personal Precautions: Keep unnecessary personnel away. Avoid dust formation. Wear gloves, lab coat, and eye protection.
Environmental Precautions: Prevent leakage or spillage into drains, groundwater, or surface water.
Methods for Clean-up: Use inert material (dry sand, vermiculite) for absorption. Sweep up avoiding dust formation. Store in closed, labeled containers for proper disposal. Ventilate affected area.
Handling: Work in well-ventilated areas. Avoid contact with skin, eyes, and clothing. Prevent dust formation. Wash hands after handling.
Storage: Store in original tightly closed containers. Keep in cool, dry, and ventilated location. Protect from light and moisture. Segregate from incompatible substances (strong oxidizers, acids, bases).
Special Precautions: Lock up product as required by local regulation.
Occupational Exposure Limits: No ACGIH, OSHA, or NIOSH values set.
Engineering Controls: Operate under chemical fume hood. Use local exhaust ventilation.
Respiratory Protection: Use certified respirator if aerosol or dust likely.
Skin Protection: Protective gloves made of nitrile or neoprene. Laboratory coat or apron recommended.
Eye/Face Protection: Safety goggles with side-shields or face shield.
Hygiene Measures: Wash hands after handling; do not eat, drink, or smoke around chemical.
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not available
pH: 2.5–3.5 (1% solution)
Melting Point/Range: 163–170°C (decomposes)
Boiling Point/Range: Not applicable
Flash Point: Not applicable
Flammability: Product does not easily ignite.
Explosive Properties: No known risk.
Vapor Pressure: Not determined
Density: 1.38–1.43 g/cm³
Solubility: Highly soluble in water, slightly in ethanol, essentially insoluble in ether
Partition Coefficient: Log Kow not available.
Auto-ignition Temperature: Not available.
Decomposition Temperature: Above 163°C.
Viscosity: Not available for solid material.
Chemical Stability: Stable under recommended conditions.
Conditions to Avoid: Moisture, high temperatures, strong light.
Incompatible Materials: Strong oxidizers, strong acids and bases.
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon oxides under fire.
Polymerization: Does not occur.
Acute Toxicity: LD50 (oral, mouse) about 10 mg/kg. Harmful if swallowed.
Skin Corrosion/Irritation: Irritates skin on contact.
Eye Damage/Irritation: Causes serious eye irritation with redness and pain.
Respiratory Sensitization: May cause respiratory irritation with coughing or shortness of breath.
Chronic Effects: No reliable data on carcinogenicity, mutagenicity, or reproductive toxicity in humans.
Other Information: Avoid repeated exposure. Symptoms may involve gastrointestinal distress, skin/eye burning, or allergic response in sensitive individuals.
Toxicity: Harmful to aquatic organisms. May cause long-term adverse effects in aquatic environments.
Persistence and Degradability: No specific data available, but similar compounds tend to persist in soil/water.
Bioaccumulative Potential: No significant bioaccumulation predicted.
Mobility in Soil: Water-soluble and mobile in moist environments.
Other Adverse Effects: Avoid release into environment through careful handling and waste management.
Waste Treatment Methods: Collect and seal in containers for disposal through a licensed chemical waste contractor.
Hazardous Waste Regulations: Flush with copious water only if permitted and treatment plant can handle the compound.
Contaminated Packaging: Dispose of contaminated packaging as hazardous chemical waste.
Environmental Precautions: Do not dispose in drains or household trash.
UN Number: Not assigned for limited quantities.
Proper Shipping Name: Chemical, N.O.S. (Nafamostat Methanesulfonate)
Transport Hazards Class: Not regulated for land, sea or air transport in most countries.
Packing Group: Not applicable.
Special Precautions: Secure packaging, avoid movement or dust formation during transit.
International Inventories: Nafamostat Methanesulfonate may not be listed in inventory lists of Europe (EINECS), United States (TSCA), Canada (DSL/NDSL), Australia (AICS), China (IECSC), or Japan (ENCS).
SARA Title III (USA): Not subject to reporting.
OSHA: Not classified as hazardous under OSHA Hazard Communication Standard.
REACH: Not registered.
Other Regulations: Handle using laboratory good practices and country-specific requirements for toxic or pharmaceutical active ingredients.
Label Elements (as per GHS): Explicit display of hazard pictograms, signal word, hazard statements, and precautionary statements on packaging.
