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Product Name: N-Nitrosodimethylamine
Synonyms: NDMA, Dimethylnitrosamine
Chemical Formula: C2H6N2O
CAS Number: 62-75-9
Recommended Use: Laboratory reagent, research chemical, carcinogenicity testing
Manufacturer/Supplier: Various chemical suppliers; contact directly for emergency information
Emergency Contact Number: Refer to local chemical emergency service or CHEMTREC
GHS Classification: Carcinogenicity - Category 1A, Acute Toxicity (Oral, Dermal, Inhalation) - Category 2, Specific Target Organ Toxicity - Repeated Exposure - Category 2
Signal Word: Danger
Hazard Statements: Causes cancer, fatal if swallowed, in contact with skin, or if inhaled, may cause damage to organs through prolonged or repeated exposure
Pictograms: Skull and crossbones, Health hazard
Precautionary Statements: Avoid all exposure, use only in fume hood, wear protective gear, no smoking, wash hands thoroughly after handling
Chemical Name: N-Nitrosodimethylamine
Concentration: 98-100% pure for laboratory sample
Impurities: Trace related nitrosamines possible, consult specific batch analysis
Other Ingredients: None
Inhalation: Remove person to fresh air immediately, keep at rest, administer artificial respiration if breathing stops, seek emergency medical attention
Skin Contact: Remove all contaminated clothing, wash affected skin with plenty of soap and water, seek medical assistance promptly
Eye Contact: Rinse cautiously with water for at least 15 minutes, do not allow victim to rub eyes, obtain medical attention
Ingestion: Do not induce vomiting, rinse mouth thoroughly, never give anything by mouth to an unconscious person, seek immediate medical care
Advice to Physician: Treat as highly toxic carcinogen, provide supportive care, monitor respiratory and liver functions
Suitable Extinguishing Media: Alcohol-resistant foam, carbon dioxide, dry chemical powder
Unsuitable Extinguishing Media: Direct streams of water may spread chemical
Hazardous Combustion Products: Nitrogen oxides, carbon oxides, toxic gases
Personal Protective Equipment for Firefighters: Self-contained breathing apparatus, chemical protective suit
Special Firefighting Procedures: Evacuate area, keep upwind and as far away as possible, contain runoff from firefighting to prevent environmental contamination
Personal Precautions: Evacuate non-essential personnel, ventilate area, avoid inhalation or contact, wear full protective gear including respirator
Environmental Precautions: Prevent discharge into drains, soil, waterways, inform relevant authorities in case of contamination, protect all environmental vectors
Methods for Cleanup: Absorb spill with inert material such as vermiculite, transfer material to a suitable, tightly closed waste container, seal and label for disposal, decontaminate area with dilute sodium hypochlorite or potassium permanganate solution for final cleaning, dispose as hazardous waste
Precautions for Safe Handling: Work only in closed system or fume hood, minimize all aerosol or vapor generation, avoid ingestion, inhalation, skin and eye contact, do not eat or drink near substance, wash hands and exposed skin thoroughly after use
Safe Storage Conditions: Store in tightly closed container, away from light, heat, and incompatible substances, refrigerate at 2-8°C, use explosion-proof refrigerator if feasible, keep segregated from strong oxidizers, acids, alkalis, and reducing agents
Incompatible Materials: Oxidizing agents, reducing agents, acids, alkalis, sources of ignition
Exposure Limits: OSHA TWA: 0.001 ppm (skin); ACGIH TLV: 0.0005 ppm (inhalable fraction and vapor, skin)
Engineering Controls: Work inside chemical fume hood, use closed transfer systems, local exhaust ventilation required
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), tightly fitting safety goggles, lab coat or Tyvek suit, NIOSH-approved respirator for organic vapors
Hygiene Measures: Remove contaminated clothing before leaving work area, avoid touching face, do not eat, drink, or smoke during use, dispose of protective equipment according to hazard guidelines
Appearance: Clear, yellowish liquid
Odor: Faint, characteristic amine-like odor
Molecular Weight: 74.08 g/mol
Boiling Point: 151°C (304°F)
Melting Point: -50°C (-58°F)
Flash Point: 57°C (135°F)
Vapor Pressure: 3.9 mmHg at 25°C
Solubility: Miscible with water, alcohols, and ether
pH: Not available
Partition Coefficient (log Kow): 0.57
Autoignition Temperature: 385°C (725°F)
Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Chemical Stability: Normally stable under recommended storage conditions, sensitive to light and heat, decomposes readily when exposed to acids or bases
Reactivity: May react violently with oxidizing agents or reducing agents, forms toxic and potentially explosive mixtures with incompatible chemicals
Hazardous Decomposition Products: Cancer-causing nitrosamines, nitrogen oxides, carbon monoxide, carbon dioxide
Conditions to Avoid: Exposure to light, heat, open flame, incompatibles, long-term storage
Acute Toxicity: Oral LD50 (rat) 23 mg/kg, inhalation LC50 (rat) 0.12 mg/L/4h, highly toxic in small doses
Chronic Toxicity: Strong evidence for carcinogenicity in humans and animals even at very low exposures, targets primarily liver causing necrosis, cirrhosis, tumors
Likely Routes of Exposure: Inhalation, ingestion, skin absorption
Symptoms of Exposure: Nausea, vomiting, dizziness, headache, abdominal pain, jaundice, liver failure, death
Carcinogenicity Status: IARC Group 2A (probably carcinogenic to humans), NTP - known human carcinogen, included on EPA and OSHA carcinogen lists
Other Health Effects: Mutagenic in multiple test systems, possible adverse effects to reproductive organs and immune system
Ecotoxicity: Highly toxic to aquatic organisms, concentrations of 1 μg/L can harm fish, classified as an emerging environmental contaminant
Persistence and Degradability: Low to moderate persistence, slow natural degradation in soil and water, photodegradation possible on water surfaces
Bioaccumulation Potential: Low, but chronic presence leads to significant biological harm
Mobility in Soil: High mobility, can leach rapidly to groundwater due to high solubility
Other Adverse Effects: Disrupts microbial and invertebrate populations, may contaminate drinking water sources
Disposal Methods: Incinerate in chemical incinerator equipped with afterburner and scrubber, must comply with local, state, and federal environmental statutes
Container Disposal: Triple rinse empty containers before disposal, destroy by puncturing and send for approved chemical waste processing
Precautions: Do not pour into drains, surface waters, or regular waste streams, professional hazardous waste disposal required, document all transfers and destruction
UN Number: UN 2522
Proper Shipping Name: N-Nitrosodimethylamine
Hazard Class: 6.1 (Toxic substances)
Packing Group: I (most dangerous)
Labels: Toxic
Transport Method: Regulated for air, maritime, road, and rail; secure packaging required to prevent leaks and exposure
Special Precautions: Notify carriers of toxicity, use only approved, leak-proof packaging, keep away from incompatible shipments
OSHA: Regulated as a carcinogen and hazardous material
EPA: Listed under Clean Water Act priority pollutants, SARA Title III Section 313, RCRA hazardous waste
TSCA: Listed in TSCA inventory
State Regulations: Listed on California Proposition 65 as a chemical known to cause cancer
Other International Lists: Included in Europe REACH candidate list, Japan PRTR Law, Australia AICS
Workplace Restrictions: Strict controls for handling, use only by skilled personnel, periodic monitoring and risk assessment mandatory
