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Product Name: N,N,N',N'-Tetramethylethylenediamine
Common Names: TMEDA, Pentamethylethylenediamine
CAS Number: 110-18-9
EC Number: 203-744-6
Recommended Use: Laboratory chemical, reagent for organic synthesis, complexing agent in coordination chemistry
Supplier: Chemical distributor or manufacturer contact details can be found on packaging label
Emergency Phone Number: Check facility-specific emergency contact information, Poison Control Center, emergency services
Classification: Flammable liquid (Category 2), Acute toxicity (oral, Category 4), Acute toxicity (inhalation, Category 4), Acute toxicity (dermal, Category 4), Skin corrosion/irritation (Category 2), Eye damage/irritation (Category 2A)
Signal Word: Danger
Pictograms: Flame, Exclamation Mark, Health Hazard
Hazard Statements: Highly flammable liquid and vapor, Harmful if swallowed, in contact with skin, or if inhaled, Causes skin irritation and serious eye irritation
Precautionary Statements: Keep away from heat/sparks/open flames/hot surfaces, avoid breathing vapors, use personal protective equipment, wash skin thoroughly after handling, use only outdoors or in well-ventilated area, call poison center if you feel unwell, if on skin wash with plenty of water, if in eyes rinse cautiously with water
Chemical Identity: N,N,N',N'-Tetramethylethylenediamine
Synonyms: TMEDA
CAS Number: 110-18-9
EC Number: 203-744-6
Concentration: 99-100% (as supplied)
Impurities/Additives: No significant impurities affecting the classification or labeling
Molecular Formula: C6H16N2
Molecular Weight: 116.21 g/mol
Inhalation: Move person to fresh air, keep at rest, seek medical attention if symptoms occur, give artificial respiration if breathing has stopped, do not give anything by mouth to an unconscious person
Skin Contact: Remove contaminated clothing, wash skin with soap and water, seek medical advice if skin irritation or rash develops, launder clothing before reuse
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy to do, continue rinsing, get medical attention
Ingestion: Rinse mouth, get immediate medical attention, do not induce vomiting unless directed by medical personnel
Most Important Symptoms: Burning sensation, coughing, headache, severe eye or skin irritation, difficulty breathing
Immediate Medical Attention/Special Treatment: Treat symptomatically, maintain airway and circulation, consider activated charcoal under medical supervision if ingestion occurred recently
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, alcohol-resistant foam
Unsuitable Extinguishing Media: Water jet (can spread flammable liquid)
Specific Hazards: Vapors may travel to ignition source and flash back, formation of toxic gases including nitrogen oxides and carbon oxides on combustion, containers may explode in fire
Protective Equipment for Firefighters: Self-contained breathing apparatus (SCBA), full protective clothing
Special Procedures: Use water spray to cool containers exposed to fire, prevent run-off from entering drains or watercourses, ventilate area after fire is controlled
Personal Precautions: Evacuate unnecessary personnel, ventilate area, eliminate all ignition sources, avoid inhalation of vapors, wear appropriate personal protective equipment including gloves and safety goggles
Environmental Precautions: Prevent spillage from entering drains, sewers, and water courses, contain spills using earth, sand, or other non-combustible material
Methods for Clean-Up: Absorb with inert absorbent material (like sand, diatomaceous earth), collect in suitable, tightly closed containers for disposal, provide adequate ventilation during clean-up, clean contaminated surface thoroughly, dispose according to local regulations
Handling Requirements: Handle in well-ventilated spaces, keep away from sources of ignition, use spark-proof tools and explosion-proof equipment, avoid contact with skin, eyes, and clothing, wash hands after handling, avoid inhaling vapor or mist, use only with proper grounding and bonding during transfer
Storage Conditions: Store in tightly closed, properly labeled containers, keep in cool, dry, well-ventilated area away from heat and direct sunlight, store away from strong oxidizers, acids, halogenated compounds, protect from physical damage, segregate from incompatible chemicals, keep away from food and drink
Occupational Exposure Limits: No specific occupational exposure limits established; adhere to internal workplace limits if applicable
Engineering Controls: Work in fume hood or with exhaust ventilation, ensure eyewash station and emergency shower are nearby
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene recommended), eye protection (safety goggles or face shield), flame-resistant lab coat, use of respirator with organic vapor cartridge if ventilation is insufficient, appropriate footwear
Hygiene Measures: Wash hands before breaks and after work, do not eat or drink in work area, remove and wash contaminated clothing before reuse
Appearance: Colorless to pale yellow, low-viscosity liquid
Odor: Ammonia-like, strongly fishy
Odor Threshold: Not available
pH: Strongly basic in aqueous solution
Melting Point/Freezing Point: –56°C (–68.8°F)
Boiling Point/Range: 121–122°C (250–252°F)
Flash Point: 17°C (63°F, closed cup)
Evaporation Rate: Not determined
Flammability (solid, gas): Not applicable (liquid)
Upper/Lower Flammability or Explosive Limits: 1.0–8.2% (v/v) in air
Vapor Pressure: 10.1 mmHg at 20°C
Vapor Density (air=1): 4.02
Relative Density: 0.775 g/cm³ at 20°C
Solubility: Miscible with water and many organic solvents
Partition Coefficient (log Kow): –0.003
Auto-ignition Temperature: 220°C (428°F)
Decomposition Temperature: Not available
Viscosity: Low, fluidic under normal conditions
Chemical Stability: Stable under normal temperatures and recommended handling conditions
Reactivity: Reacts vigorously with strong acids, oxidizers, and halogenated compounds
Conditions to Avoid: Heat, sparks, open flames, static discharge, direct sunlight, incompatible materials
Incompatible Materials: Acids, strong oxidizers (such as hydrogen peroxide, nitric acid), halogens, acid chlorides, anhydrides, copper, aluminum
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, other potentially toxic fumes in event of fire or thermal decomposition
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: LD50 (oral, rat): 1050 mg/kg; LD50 (dermal, rabbit): 2500 mg/kg; LC50 (inhalation, rat): 1.2 mg/L (4h, aerosol)
Skin Corrosion/Irritation: Causes skin irritation, may cause burns with prolonged or repeated contact
Serious Eye Damage/Irritation: Causes serious eye irritation, risk of severe eye damage
Respiratory Sensitization: Not classified as a respiratory sensitizer
Skin Sensitization: Not expected to cause skin sensitization
Germ Cell Mutagenicity: No data indicating mutagenic effects
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: No data on reproductive impact
STOT—Single Exposure: Can cause drowsiness, dizziness, central nervous system depression
STOT—Repeated Exposure: Prolonged exposure may damage liver and kidneys
Aspiration Hazard: Not classified as aspiration hazard
Ecotoxicity: Toxic to aquatic life; aquatic LC50 (guppy: Poecilia reticulata, 96 h): 75 mg/L
Persistence and Degradability: Readily biodegradable in water and soil under aerobic conditions
Bioaccumulative Potential: Low potential for bioaccumulation (log Kow <0)
Mobility in Soil: High mobility, fully miscible in water, likely to enter groundwater if spilled
Other Adverse Effects: May raise local pH in water bodies, altering aquatic environments, vapors contribute to ground-level ozone formation
Waste Treatment Methods: Collect and contain liquid waste in appropriately labeled containers, incinerate under controlled conditions at an approved chemical waste facility
Disposal of Product: Avoid release into environment, do not pour into drains, contact licensed waste disposal contractor
Contaminated Packaging: Empty containers should be rinsed and disposed as hazardous waste under local and national regulations, do not reuse packaging for other chemicals or purposes
Special Precautions: Follow all federal, state, and local environmental control regulations for disposal
UN Number: UN2372
Proper Shipping Name: Tetramethylethylenediamine
Transport Hazard Class: 3 (Flammable Liquids)
Packing Group: II
Labels Required: Flammable Liquid (Class 3)
Special Provisions: Keep containers tightly closed, transport in upright position to prevent leakage, protect against physical damage
Marine Pollutant: Not listed as marine pollutant
Transport in Bulk: Consult transport regulations for bulk shipment requirements
TSCA: Listed in the United States Toxic Substances Control Act Inventory
REACH: Registered and listed under European Union REACH regulation
OSHA Hazards: Flammable liquid, harmful by ingestion/inhalation/dermal, irritant
SARA Title III: Subject to reporting under certain SARA sections
Canadian WHMIS Classification: B2 (Flammable liquid), D2B (Toxic material causing other toxic effects)
California Proposition 65: Not listed
Other National/International Regulations: Check local, regional, and national legislation for relevant handling and reporting requirements
