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Chemical Name: N,N-Diisopropylethylamine
Common Names: DIPEA, Hunig’s base
CAS Number: 7087-68-5
Physical Form: Liquid with a noticeable ammonia-like odor
Main Uses: Organic synthesis, acid scavenging, pharmaceutical manufacturing
Major Industries: Laboratories, pharma, chemical synthesis
Appearance: Clear, colorless to pale yellow liquid
Hazard Classifications: Flammable liquid, irritant, harmful if swallowed or in contact with skin
Signal Word: Warning
Key Dangers: Easily ignites, dense vapors can travel along surfaces, causes nose, throat, and skin irritation
Acute Exposure Risks: Inhalation can burn throat and airways, shortness of breath or coughing, skin reddening, eye burning, nausea or vomiting if ingested
Chronic Risks: Prolonged contact dries skin, continuous inhalation might affect respiratory system
Active Ingredient: N,N-Diisopropylethylamine
Concentration: Typically over 98% purity in lab and industry supply
Other Components: Minor impurities from synthesis processes, typically below one percent
Type: Secondary and tertiary amine
Eye Contact: Flush eyes with running water for at least fifteen minutes, hold eyelids open, remove any contact lenses
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with plenty of water and mild soap
Inhalation: Move to fresh air quickly, rest, get medical help for breathing problems
Ingestion: Rinse mouth, seek medical attention, do not induce vomiting unless instructed by a medical professional
Medical Note: Ensure responders know what substance is involved, provide safety data to physicians
Flammability: Catches fire at moderately low temperatures, flash point near 50°C
Combustion Hazards: Burning makes toxic nitrogen oxides, dense smoke
Extinguishing Media: Use foam, dry chemical powder, or CO2—avoid water jets due to spread of flammable material
Protective Gear: Wear breathing apparatus and protective gear, avoid exposure to hot vapors
Fire Response: Cool exposed containers with water spray, keep surroundings ventilated
Containment: Use non-sparking tools for cleanup, block sewers and drains to prevent environmental release
Cleanup Procedure: Absorb spillage in inert material such as sand or earth, collect in sealable containers
Personal Protection: Gloves, goggles, and chemical-protective clothing essential during cleanup
Ventilation: Open windows and use exhaust fans; avoid inhaling vapors
Disposal: Dispose of contaminated materials according to regional environmental regulations
Safe Handling: Always work in fume hood, ground and bond containers to prevent static charge
Storage: Keep tightly closed in a cool, well-ventilated area, away from sunlight, ignition sources, acids, and oxidizers
Incompatible Materials: Strong oxidizers, acids, bases; contact may cause hazardous reactions
Shelf Life Issues: Prolonged storage can lead to impurity buildup or container degradation
Spill Readiness: Emergency spill kits and fire extinguishers should be on-hand nearby
Ventilation: Local exhaust ventilation keeps concentrations below recommended limits
Personal Protective Equipment: Nitrile gloves, lab goggles, flame-resistant lab coat; use full-face protection in risk of splashing
Breathing Protection: Respirator mask if vapor concentration rises or in poorly ventilated labs
Work Practices: Avoid direct skin or eye contact, wash hands before breaks or meals, no eating or drinking where chemical is used
Exposure Limits: No established occupational exposure limit in some countries, handle as hazardous chemical
Boiling Point: Around 127-128°C
Melting Point: Less than -90°C
Vapor Pressure: Moderate at room temperature
Solubility: Slightly soluble in water, dissolves well in organic solvents
Odor: Strong ammonia-like
Density: About 0.74 g/cm³ at 20°C
Evaporation Rate: Faster than water
pH: Strongly alkaline in water-based solutions
Chemical Stability: Stable under typical handling and storage, can degrade with light or strong acids
Incompatible Substances: Acids, oxidators, strong bases, acid chlorides
Decomposition Products: Nitrogen oxides, sometimes carbon monoxide in fire
Reaction Risks: Mixing with acid or oxidizer gives off heat, vapors
Acute Effects: Inhaled vapor stings, can irritate lungs and nasal passages; swallowed doses cause gastrointestinal upset
Skin Effects: High contact dries and cracks skin, painful rash possible
Eye Effects: Splash burns eyes, causes rapid burning and watering
Long-Term Risks: Regular exposure may increase sensitivity, cause dermatitis, or hurt organs over years
Affected Groups: Chemistry workers and students suffer most exposures during transfer, mixing, or spills
Eco-Toxicity: Harmful to aquatic life in fresh and salt water
Persistence: Breaks down slowly if released in large amounts
Mobility: Moves rapidly in soil, drains to water sources
Bioaccumulation: Low potential, but ongoing dumps into water can magnify effects
Precaution: Avoid rinsing down drains or into soil; treatment before disposal is safest choice
Safe Disposal: Collect waste in labeled, sealed containers, send to licensed hazardous waste processor
Regulatory Compliance: Follow regional hazardous waste laws to avoid fines and pollution
Residue Handling: Absorb with non-flammable materials, keep chemical waste away from normal garbage
Chemical Reuse: Recycle or recover pure product where options exist in advanced facilities
Shipping Name: Flammable liquid
UN Number: Transported under UN1993 in most cases
Packing Group: II, moderate danger on the scale
Hazard Labels: Flammable liquid sticker required
Transport Instructions: Seal in corrosion-resistant drum or can, upright, protected from shocks or high heat, legal shipping documents needed
Hazard Communication: Included in lab chemical hazard lists worldwide
Environmental Regulations: Strict disposal and emissions controls exist in Europe, US, and other major markets
Workplace Safety: Covered by chemical hygiene plans, PPE requirements, fire safety rules
Right-to-Know Laws: Users must be trained before handling, keep MSDS up-to-date on site
Labeling: All containers need chemical name, hazard warnings, and handling instructions readable at glance
