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Product Name: N,N'-Dicyclohexylcarbodiimide
Synonyms: DCC, Carbodiimide, dicyclohexyl-
Chemical Formula: C13H22N2
Molecular Weight: 206.33 g/mol
CAS Number: 538-75-0
Intended Use: Organic synthesis reagent in peptide coupling and other condensation reactions
Supplier Information: Manufacturer address, emergency contact number, and technical support details available from supplier’s label or safety office.
GHS Classification: Acute toxicity (Oral, Dermal, Inhalation), Skin Corrosion/Irritation, Sensitization (Skin, Respiratory), Eye Irritation
Signal Word: Danger
Hazard Statements: Harmful if swallowed. Causes severe skin burns and eye damage. Suspected of causing allergic skin reactions. Harmful if inhaled.
Pictograms: Corrosive, Exclamation Mark
Precautionary Statements: Avoid breathing dust or vapors. Wear protective gloves, eye and face protection. Do not eat, drink or smoke near the product. Wash exposed skin thoroughly after handling. Use only outdoors or in a well-ventilated area.
Chemical Name: N,N'-Dicyclohexylcarbodiimide
Chemical Formula: C13H22N2
Content: ≥99% (purity typical for laboratory and industrial use)
Impurities/Other Components: Minimal levels of byproducts, generally trace dicyclohexylurea and related compounds.
Other Information: This substance contains no additional components or impurities affecting its classification.
General Advice: Remove victim from exposure immediately. Provide fresh air. Seek medical attention for all exposures.
Inhalation: Move to fresh air. Keep at rest. Seek medical help if coughing, shortness of breath, or symptoms persist.
Skin Contact: Remove contaminated clothing and shoes. Rinse skin with water and soap for at least 15 minutes. Seek immediate medical attention.
Eye Contact: Rinse cautiously with plenty of water for at least 15 minutes. Remove contact lenses if possible.
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek immediate medical help. Provide healthcare professional with product information.
Suitable Extinguishing Media: Dry chemical, CO2, sand, or alcohol-resistant foam
Unsuitable Media: Do not use water jet, as it may spread the fire.
Special Hazards: Toxic and irritating fumes (such as cyanides, nitrogen oxides) can form during combustion. Rapidly decomposes under intense heat.
Protective Equipment: Firefighters need full protective clothing, self-contained breathing apparatus, and avoid inhaling gases.
Additional Advice: Remove containers from fire area if safe. Cool containers with water spray to prevent overheating and explosion.
Personal Precautions: Evacuate unnecessary personnel. Isolate area. Avoid breathing dust or vapors. Wear suitable protective equipment including respiratory protection.
Environmental Precautions: Prevent product from entering drains or waterways. Contain spill with dikes or absorbent materials.
Cleanup Methods: Scoop up and collect in a suitable container for proper disposal. Clean contaminated area with soap and water. Ventilate the area after cleanup.
Decontamination: Wash spill site after material pickup is complete.
Handling: Handle in fume hood or well-ventilated place. Avoid contact with skin, eyes, and clothing. Do not eat, drink, or smoke around the material. Wash hands after working with DCC.
Storage Conditions: Store in a tightly closed original container. Keep in cool, dry, and well-ventilated place. Store away from water, strong acids, and oxidizers.
Storage Temperature: Preferred range 2–8°C, away from direct sunlight and heat sources.
Incompatibilities: Avoid exposure to moisture, strong acids, bases, oxidizers, and reducing agents.
Engineering Controls: Use fume hood or local exhaust ventilation. Install eyewash and safety shower near handling area.
Occupational Exposure Limits: No established exposure limits. Follow general dust limit guidance.
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), lab coat, safety goggles, and face shield. Use P2 or higher filter mask for dust or powder. Remove contaminated clothing and wash before reuse.
Hygiene Measures: Wash hands before breaks and after handling. Do not touch face or exposed skin parts during manipulation.
Appearance: White to off-white crystalline powder
Odor: Faint, characteristic
Odor Threshold: Not available
pH: Not available
Melting Point: 34–36°C
Boiling Point: Decomposes before boiling
Flash Point: >110°C (closed cup)
Evaporation Rate: Not determined
Flammability: Not classified as flammable
Explosive Properties: Not explosive, but dust may create combustible conditions
Vapor Pressure: Low, not significant at room temperature
Solubility: Insoluble in water, soluble in organic solvents such as dichloromethane, chloroform, and toluene.
Density: 1.32–1.35 g/cm³
Partition Coefficient (log Pow): 4.6 estimated
Auto-Ignition Temperature: No data
Chemical Stability: Stable under dry and recommended storage conditions
Reactivity: Reacts with water and moisture, forming dicyclohexylurea
Hazardous Reactions: Reacts vigorously with acids, oxidizers, reducing agents. Liberates heat on contact with water. Not compatible with bases.
Hazardous Decomposition Products: Emits toxic fumes of nitrogen oxides, cyanides, and carbon monoxide during combustion or degradation
Others: Contact with moisture leads to hydrolysis.
Acute Toxicity: Oral LD50 (rat): ~750 mg/kg; Inhalation data limited; Dermal LD50 (rabbit): estimated >2000 mg/kg
Skin Corrosion: Severe irritation, possible burns
Eye Damage: Severe injury, risk of permanent damage
Sensitization: Known skin and respiratory sensitizer. Prolonged or repeated exposure increases risk of allergic reaction.
Long-term Effects: Data limited; sensitization and chronic skin or respiratory problems may develop
Other Effects: Symptoms include red skin, dryness, pain, coughing, and sore throat.
Carcinogenicity: Not listed as human carcinogen in IARC, NTP, or OSHA databases
Mutagenicity/Teratogenicity: Not documented
Ecotoxicity: Product toxic to aquatic organisms. Do not discharge to surface water. Acute and chronic effects on aquatic life remain under-studied.
Persistence/Degradability: Hydrolyzes slowly in water to dicyclohexylurea, which may persist in environment.
Bioaccumulation Potential: Expected to be high due to log Pow value.
Mobility: Low water solubility limits mobility, though powders can be swept by wind or water.
Other Harmful Effects: Can damage flora and fauna if spilled in large quantities.
Waste Disposal: Collect material in sealed, labeled containers. Do not dispose in drains or natural environments.
Recommended Disposal: Incinerate in approved chemical waste facility. Consult state and local guidelines for chemical waste disposal.
Contaminated Packaging: Treat empty containers as hazardous, rinse thoroughly before discarding.
Precautions: Wear full personal protective equipment during disposal process.
UN Number: 2811
Proper Shipping Name: Toxic Solid, Organic, N.O.S. (contains DCC)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Classified as harmful to aquatic organisms, see ecological section.
Special Precautions: Keep containers tightly closed and upright during transport. Consult carrier for compatibility with other chemicals.
Additional Information: Follow national and international shipment regulations to ensure safety of people and environment.
Labeling (GHS): Corrosive, Harmful, Sensitizer
OSHA: Hazardous substance under OSHA Hazard Communication Standard
TSCA (US): Listed in TSCA inventory
EU Regulation: Complies with REACH Annex II; Substance of concern for skin allergy notifications.
Other Regulations: Subject to workplace safety and environmental legislation in multiple jurisdictions.
Worker Protection: Enforce safe handling, training, and protective measures in workplace to manage exposure risks.
Community Right-to-Know: Product disclosure may be required under local or state regulations.
