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Chemical Name: N-Ethyl-N-(2-Hydroxyethyl)Perfluorooctanesulfonamide
Synonyms: FOSA, PFOSE, Perfluorooctane sulfonamide, 2-Hydroxyethyl-N-ethyl perfluorooctylsulfonamide
CAS Number: 1691-99-2
Recommended Use: Surface treatment agent, chemical intermediate, manufacturing of water and oil-resistant materials
Supplier Information: Manufacturer address, phone number, emergency contact, and e-mail for technical support
Emergency Phone Number: Provided by supplier or local emergency services
Hazard Classification: Acute Oral Toxicity Category 4, Specific Target Organ Toxicity (Repeated Exposure) Category 2, Skin and Eye Irritant, Aquatic Toxicity (Chronic) Category 1
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause damage to organs through prolonged or repeated exposure, very toxic to aquatic life with long-lasting effects
Pictograms: Exclamation mark; health hazard; environmental hazard symbols
Precautionary Statements: Avoid release to the environment, wear protective gloves and eye protection, wash hands thoroughly after handling, do not eat or drink or smoke when using
Other Hazards: Can build up in the environment, persistent, bioaccumulative, risk of long-term harm to wildlife and aquatic organisms
Substance: N-Ethyl-N-(2-Hydroxyethyl)Perfluorooctanesulfonamide
Chemical Formula: C10H20F17NO3S
Concentration: 100% (pure substance)
Impurities and Stabilizing Additives: Trace levels of related perfluorinated compounds and residual solvents from synthesis, specific impurities disclosed on request
Inhalation: Move victim to fresh air immediately, keep at rest in comfortable position for breathing; seek medical help if symptoms persist such as coughing, wheezing, or chest tightness
Skin Contact: Remove any contaminated clothing, rinse skin under running water for at least 15 minutes, use gentle soap, avoid harsh scrubbing; medical care recommended for irritation or persistent lesions
Eye Contact: Rinse eyes cautiously with water for several minutes, remove contact lenses if present, continue rinsing; urgent medical examination if pain or vision changes occur
Ingestion: Rinse mouth, do not induce vomiting, give small amounts of water if conscious; prompt medical attention required due to potential systemic toxicity
Most Important Symptoms: Redness, burning, gastrointestinal upset, headache, weakness, can trigger allergic skin reactions
Notes for Doctor: Supportive and symptomatic treatment; monitor liver and kidney function, consider activated charcoal for recent ingestion; monitor for potential delayed effects
Suitable Extinguishing Media: Use foam, dry chemical, or carbon dioxide to extinguish, water spray for large fires to cool surfaces and protect personnel
Unsuitable Media: Direct water stream may spread chemical or contaminant fire runoff
Special Hazards: Releases toxic, corrosive vapors including hydrogen fluoride (HF) and sulfur oxides when heated intensely or during combustion
Protective Equipment for Firefighters: Self-contained breathing apparatus with full face mask, chemical protective clothing impervious to chemicals
Specific Methods: Move containers from fire area if possible without risk, keep fire-exposed storage containers cool with water spray, prevent contaminated water runoff
Decomposition Products: Hydrogen fluoride, perfluoroalkyl compounds, nitrogen oxides, sulfur oxides released in case of intense fire extermination
Personal Precautions: Evacuate unnecessary personnel, ventilate area, use chemical-resistant gloves, goggles, and protective suit
Protective Equipment: Respirators if vapor exposure possible, chemical splash goggles, rubber or plastic gloves, chemical-resistant footwear
Emergency Procedures: Restrict access, isolate spill area, eliminate ignition sources, ensure adequate ventilation
Environmental Precautions: Prevent further leakage or spillage if safe, stop material from entering drains, sewers, or watercourses, report major contamination to authorities
Containment and Cleanup: Absorb with inert materials like sand, collect in leak-proof containers, clean area thoroughly with detergent solution, ventilate; dispose of according to waste regulations
Safe Handling: Work with chemical in well-ventilated facilities, avoid inhalation and skin or eye exposure, handle with chemical-resistant gloves and safety goggles, avoid eating, drinking, or smoking in work area, clean surfaces after use
Storage Conditions: Store in tightly closed original containers, in cool, dry, well-ventilated area away from direct sunlight and heat sources, separate from incompatible substances like strong oxidizers or bases
Storage Stability: Avoid temperature extremes; stable under recommended storage conditions, decomposition can occur if exposed to strong acids or prolonged heating
Special Precautions: Segregate from food, feed, and water supplies, label clearly for chemical hazard identification, maintain inventory with periodic safety inspections
Exposure Limits: No occupational exposure limit set by OSHA or ACGIH; minimize exposure by engineering controls and personal protective equipment
Engineering Controls: Local exhaust and general room ventilation sufficient for most applications, chemical fume hoods strongly recommended during open transfers
Personal Protective Equipment: Nitrile, neoprene, or butyl gloves; safety goggles or face shield; impervious apron or laboratory coat; disposable chemical-resistant footwear; respiratory protection if vapor levels rise
Hygiene Measures: Wash hands, face, and exposed skin before eating, drinking, smoking, or leaving work area, handle contaminated clothing with care, routine laundering required
Environmental Controls: Regular monitoring of workplace air, containment of process systems to avoid accidental emissions
Appearance: Oily liquid, usually transparent to pale yellow
Odor: Faint, musty
Odor Threshold: Not established
pH: Neutral (5.5–7.0 in 5% aqueous solution)
Melting Point: -50°C
Boiling Point: Approximately 190°C at 760 mmHg
Flash Point: Not easily flammable, estimated above 75°C
Evaporation Rate: Very low
Flammability: Not classified as flammable
Vapor Pressure: <0.01 mmHg at 25°C
Vapor Density: Heavier than air
Relative Density: 1.65–1.75 g/cm³ (20°C)
Solubility: Slightly soluble in water, soluble in organic solvents like ethanol or acetone
Coefficient n-octanol/water (log Kow): >6 (highly lipophilic)
Autoignition Temperature: >220°C
Decomposition Temperature: >200°C
Viscosity: Moderate (exact value depends on conditions)
Molecular Weight: 523.3 g/mol
Chemical Stability: Stable in sealed containers under recommended storage and handling; slow degradation in light and air over long periods
Materials to Avoid: Strong oxidizing agents, strong bases, strong reducing agents, incompatible with hot surfaces and open flames
Possibility of Hazardous Reactions: No hazardous polymerization under normal conditions
Incompatible Conditions: High temperature conditions, open flames, contact with strong acids or bases
Hazardous Decomposition: Releases toxic gases including hydrogen fluoride, sulfur oxides, and perfluorinated fragments once heated or burned intensely
Acute Toxicity: Oral LD50 (rat): estimated 300–2000 mg/kg; dermal, inhalation not fully established
Chronic Exposure: Potential for liver, kidney, and immune system effects observed in animal studies, possible reproductive toxicity
Skin Corrosion/Irritation: Causes moderate, sometimes persistent irritation
Eye Damage/Irritation: Contact results in burning, redness, watering
Respiratory Sensitization: Irritant with potential for chronic cough or shortness of breath after prolonged exposure
Carcinogenicity: Not classified as carcinogenic by IARC, ACGIH, NTP, or OSHA, but concerns about perfluoroalkyl substances in general
Mutagenicity: Data lacking for pure compound; not expected based on structure
Reproductive Toxicity: Some evidence of reproductive effects in long-term animal studies; human risk remains unclear
Other Health Hazards: Risk of bioaccumulation, persistent in biological systems, bodily elimination slow
Aquatic Toxicity: Extremely toxic to aquatic organisms, fish LC50 <1 mg/L over 96 hours, significant long-term harm to aquatic ecosystems
Persistence and Degradability: Not readily biodegradable; may persist in environment for many years
Bioaccumulative Potential: Strong tendency to bioaccumulate in living organisms and sediment
Mobility in Soil: Low volatility, moderate soil mobility, risk for groundwater contamination via runoff
Other Adverse Effects: Accumulates through food web, hazardous to birds and mammals over time, serious concerns for environmental regulators
Waste Treatment Methods: Collect waste in closed, properly labeled containers, do not landfill or pour into drains, incinerate at high temperature (above 1100°C) in licensed chemical incinerator equipped with scrubbers for hydrogen fluoride and sulfur oxides
Contaminated Packaging: Triple rinse containers, puncture or crush before disposal, treat rinse water as hazardous waste
Disposal Restrictions: Consult national and local regulations for hazardous waste disposal permits, report any environmental spillage
Special Notes: Minimize quantities, keep chemical out of natural waterways, secondary containment advised for bulk disposal
UN Number: 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains N-Ethyl-N-(2-Hydroxyethyl)Perfluorooctanesulfonamide)
Transport Hazard Class: 6.1 (toxic substances)
Packing Group: III
Labels: Skull and crossbones (toxic), environmental hazard, keep away from foodstuffs
Special Precautions: Must travel in approved containers with spill-proof seals, emergency response guide in shipping documentation; keep segregated from incompatible loads
Environmental Hazards: Dangerous to aquatic environments, must notify authorities in case of major spillage during transit
International Inventories: Listed on TSCA (Toxic Substances Control Act) Inventory, included in European REACH regulation candidate list as Substance of Very High Concern (SVHC)
US Federal Regulations: SARA Title III (313) listed, CERCLA hazardous substance, notification required for substantial environmental release
State Regulations: Listed by several US states as hazardous, requirements for workplace exposure, notification, and environmental protection
Other Regulations: Subject to international treaties regarding persistent organic pollutants (Stockholm Convention listing under evaluation), restrictions expected in future based on environmental risk
Label Elements: GHS-compliant chemical safety labeling required, hazard pictograms, signal word, hazard statements, precautionary advice
Worker Safety: Employee Right-to-Know laws apply, training, documented PPE, hazard communication and exposure monitoring required in workplace
