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Product Name: N-Ethyl-M-Toluidine
Chemical Formula: C9H13N
Synonyms: N-Ethyl-3-methylaniline, N-Ethyl-meta-toluidine, N-Ethyl-m-tolylamine
CAS Number: 102-27-2
EC Number: 203-526-3
Recommended Use: Organic synthesis, chemical laboratory research, dye and pigment production
Manufacturer/Supplier: Information found on commercial packing or supplier website
Contact Information: Refer to supplier’s latest documents for phone, address, emergency information
GHS Classification: Acute toxicity (oral, dermal, inhalation), skin irritation, serious eye irritation, aquatic toxicity
Hazard Symbols: Skull and crossbones, exclamation mark, environmental hazard
Signal Word: Danger
Hazard Statements: Toxic if swallowed, in contact with skin, or if inhaled; Causes skin irritation; Causes severe eye irritation; Toxic to aquatic life with long lasting effects
Precautionary Statements: Avoid breathing dust, fume, gas, mist, vapors, spray; Wear protective gloves, eye protection, face protection; Wash exposed skin thoroughly after handling; Avoid release to the environment
Routes of Exposure: Inhalation, dermal, oral
Target Organs: Blood, liver, kidneys, central nervous system
Chemical Identity: N-Ethyl-M-Toluidine
Concentration: 98-100%
Impurities: Less than 2% by weight, may include trace organic solvents and related aromatic amines
Molecular Weight: 135.21 g/mol
Physical Form: Liquid, colorless to light yellow
Inhalation: Remove victim to fresh air, keep at rest, consult a physician if symptoms persist, provide artificial respiration if breathing stops
Skin Contact: Remove contaminated clothing, wash affected skin immediately with soap and water for at least 15 minutes, seek medical attention for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes (minimum of 15 minutes), remove contact lenses if present and easy to do, continue rinsing, obtain medical attention
Ingestion: Rinse mouth with water, never give anything by mouth to an unconscious person, do not induce vomiting unless directed by a physician, seek immediate medical advice
Early Symptoms: Headaches, dizziness, rapid heartbeat, skin color change (cyanosis), nausea, confusion, respiratory distress
Advice for Physician: Monitor for methemoglobinemia, provide oxygen therapy, treat symptomatically
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical, carbon dioxide, water spray (do not use strong water jets)
Specific Hazards: Vapors may form explosive mixtures with air, fire produces toxic fumes including nitrogen oxides, carbon monoxide and carbon dioxide
Protective Equipment: Wear self-contained breathing apparatus and full fire-fighting protective gear, avoid inhalation of combustion products
Special Procedures: Cool containers exposed to flames with water spray, prevent run-off from entering drains or watercourses, isolate area if possible
Explosion Data: Vapors heavier than air, can travel along surfaces to distant ignition sources
Sensitivity to Static Discharge: Moderate risk, ground/bond all handling equipment
Flash Point: 94°C (closed cup, typical value)
Personal Precautions: Use personal protective equipment (gloves, goggles, chemical-resistant clothing), avoid skin and eye contact, do not breathe vapors
Methods for Clean-Up: Ventilate area, dike spilled material to prevent spreading, absorb with inert material (sand, earth, vermiculite), collect into labeled chemical waste containers, decontaminate spill area with detergent, dispose as hazardous waste
Environmental Precautions: Prevent entry into sewers, drains, waterways, and soil, notify authorities if significant environmental contamination occurs
Spill Response: Evacuate non-essential personnel, restrict access, monitor for vapor release using appropriate detection methods, use explosion-proof equipment
Decontamination: Rinse affected area with plenty of water and detergent after spill removed
Handling: Use only in well-ventilated areas, avoid prolonged or repeated contact, wear appropriate protective equipment, prevent formation of vapor or mist, avoid exposure to incompatible substances
Hygienic Measures: Wash hands and exposed skin after handling, remove contaminated clothing and wash before reuse, do not eat, drink, or smoke during industrial use
Storage Conditions: Store in cool, dry, well-ventilated area away from sources of ignition and direct sunlight, keep container tightly closed and properly labeled
Incompatibilities: Oxidizing agents, acids, strong bases, strong reducing agents
Packaging Materials: Use containers made of compatible materials such as glass, stainless steel, or high-density polyethylene; avoid transport in unlined steel drums
Control Parameters: No established OSHA PEL, NIOSH, or ACGIH TLV; limit workplace exposure to lowest practical levels
Engineering Controls: Use local exhaust ventilation, explosion-proof equipment, chemical fume hoods, and process enclosures
Respiratory Protection: Wear approved respirators (NIOSH/MSHA) if vapor/mist is generated above safe exposure limits
Hand Protection: Use chemical-resistant gloves such as nitrile or neoprene
Eye Protection: Wear safety goggles with side shields or face shield
Skin and Body Protection: Use chemical-resistant clothing, laboratory coat, closed footwear
Environmental Exposure Controls: Prevent chemical release into drains, surface waters, or soil; use closed systems; monitor emissions regularly
Appearance: Colorless to pale yellow liquid
Odor: Aromatic, amine-like
Odor Threshold: Not established, pungent at higher concentrations
pH: Not applicable (non-aqueous liquid)
Boiling Point: 221-223°C
Melting Point: -18°C
Flash Point: 94°C
Evaporation Rate: Not measured
Flammability: Combustible
Upper / Lower Flammability Limits: Data not available
Vapor Pressure: 0.2 mmHg at 20°C
Vapor Density: Heavier than air
Relative Density (Specific Gravity): 0.94 at 20°C
Solubility (Water): Slightly soluble
Partition Coefficient (log Kow): 2.4 (estimation)
Auto-Ignition Temperature: 405°C
Decomposition Temperature: Not determined
Viscosity: Not determined
Chemical Stability: Stable under normal temperature and storage conditions
Reactivity: Reacts vigorously with acids, strong oxidizers, and certain metals, forms hazardous compounds with chlorine or strong electrophiles
Hazardous Reactions: May form toxic decomposition products under thermal stress or fire; may react exothermically with strong oxidizers
Conditions to Avoid: Heat, flames, open sparks, static electrical charges, incompatible materials
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, and other toxic gases
Polymerization: Not known to polymerize
Acute Toxicity: Oral LD50 (rat): 1020 mg/kg, Dermal LD50 (rabbit): >2000 mg/kg; Inhalation LC50 (rat, 4h): 2.8 mg/L
Skin Corrosion/Irritation: Causes skin irritation, moderate to severe depending on exposure
Serious Eye Damage/Irritation: Severe irritant; may cause eye burns, redness, tearing
Respiratory or Skin Sensitization: Limited data, but may sensitize some individuals after repeated exposure
Chronic Exposure: May cause damage to liver, kidneys, blood system, prolonged or repeated exposure leads to methemoglobinemia, anemia and other systemic effects
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a known carcinogen; structurally related amines have shown mutagenic and carcinogenic potential in animal studies
Mutagenicity: Evidence of genotoxicity in standard bacterial and mammalian assays
Reproductive Toxicity: Limited data available, effects not fully established
Other Effects: Methaemoglobinemia, CNS depression, cyanosis, hemolysis, possible increased risk of chemical burns in susceptible individuals
Ecotoxicity: Highly toxic to aquatic organisms; LC50 (fish, 96h): 3.7 mg/L, EC50 (daphnia, 48h): 2.5 mg/L
Persistence and Degradability: Not readily biodegradable, persists in the environment, potential for bioaccumulation exists
Bioaccumulative Potential: Moderate to high (log Kow: ~2.4), potential to accumulate in aquatic and terrestrial food webs
Mobility in Soil: Limited mobility in soil (adsorbs to organic matter), not expected to evaporate rapidly
Other Adverse Effects: May impact nitrogen cycle bacteria in soils, disrupt aquatic microbial ecology
Precautions: Do not allow undiluted product or large quantities to reach ground water, waterways, or sewage systems, comply with local environmental legislation
Waste Treatment Methods: Collect and contain residues in labeled waste containers, dispose of through licensed hazardous waste contractor
Contaminated Packaging: Clean containers thoroughly before recycling or disposal, destroy packaging per environmental regulations
Disposal Precautions: Avoid disposal into drains, sewers, or open environment
Regulatory Status: Classified as hazardous waste under local and international regulations (e.g., US EPA RCRA, EU Waste Directive), assign appropriate waste code for aromatic amines
Incineration: Suitable for chemical incineration in compliance with national regulations, incinerate with appropriate air pollution controls
UN Number: UN2271
UN Proper Shipping Name: Amine, liquid, toxic, N.O.S. (contains N-Ethyl-M-Toluidine)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III (minor hazard, but with potential acute toxicity)
Marine Pollutant: Yes
Special Precautions: Transport in upright, tightly closed containers; avoid carriage with incompatible substances and foodstuffs
Labeling Requirements: Toxic, Marine Pollutant, Environmental Hazard labels as per ADR, IMDG, IATA
Emergency Response Guide: Refer to ERG Guidebook for toxic liquids
US Federal Regulations: TSCA (Toxic Substances Control Act): listed; SARA Title III (EPCRA): Section 313 listed as reportable toxic chemical
EU Regulations: REACH registration required, listed in EINECS (EC Inventory), subject to harmonized classification in Annex VI of CLP Regulation
Other International Regulations: Included in Canada DSL, Australia AICS, Japan ENCS, Korea KECL inventories
Labeling: Hazard pictograms, signal word, hazard statements and precautionary statements as outlined by GHS/CLP guidelines
Local Regulations: User must comply with country-specific legislation concerning occupational exposure, environment, storage, waste management
Worker Protections: Safety training, exposure monitoring and medical surveillance may be required by national authorities
Restrictions: Restricted in specific countries as intermediate or raw material for dye, cosmetics, and medical applications
