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Product Name: N-Desmethyl Imatinib
Chemical Name: 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]phenyl]benzamide
Synonyms: N-Demethylated Imatinib, Imatinib Metabolite M1
Recommended Use: Research and pharmaceutical intermediate
Manufacturer: Please refer to packaging or shipping documentation
CAS Number: 1435934-52-7
Emergency Contact: Refer to facility safety officer
GHS Classification: Acute oral toxicity, Category 4; Specific target organ toxicity, Category 3
Label Elements: Exclamation mark pictogram; signal word: Warning
Hazard Statements: Harmful if swallowed; can cause respiratory irritation; may provoke skin and eye irritation
Precautionary Statements: Avoid inhaling dust or vapors; wear protective gloves and clothing; wash hands thoroughly after handling; do not eat or drink near the chemical; in case of inadequate ventilation, use appropriate respirators
Chemical Identity: N-Desmethyl Imatinib
Concentration: ≥98% (w/w)
Impurities: Imatinib (parent compound) ≤0.5%; other related impurities ≤1%
Molecular Formula: C28H28N6O
Molecular Weight: 464.56 g/mol
Inhalation: Move individual to fresh air; keep them in a position comfortable for breathing; seek medical advice if symptoms appear
Skin Contact: Remove contaminated clothing; wash area with soap and water; seek medical assistance if irritation continues
Eye Contact: Rinse cautiously with water for at least 15 minutes; remove contact lenses if present and easy; contact a physician immediately
Ingestion: Rinse mouth thoroughly; do not induce vomiting unless directed by a medical professional; get medical help promptly
Suitable Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide
Unsuitable Media: Avoid high-pressure water streams that may spread powder
Special Hazards: Toxic fumes of nitrogen oxides and carbon oxides may form under fire conditions
Special Protective Equipment: Firefighters need self-contained breathing apparatus and full body protective clothing
Other Advice: Move unaffected containers away from the fire area if feasible; cool containers with lots of water
Personal Precautions: Use protective equipment—gloves, eyewear, mask
Environmental Precautions: Prevent further leakage; do not allow product to reach drains or water sources
Method for Cleanup: Avoid creating dust; sweep or vacuum up and transfer to labelled container; ventilate area; wash area after material pickup
Handling: Avoid contact with skin, eyes, and clothing; handle in a chemical fume hood; avoid breathing dust
Storage Conditions: Keep containers tightly closed in a cool, dry, and well-ventilated place; protect from light and moisture; segregate from incompatible substances such as strong oxidizers
Other Precautions: Store away from food and drinking water; label storage area clearly
Engineering Controls: Use in well-ventilated areas; chemical fume hood preferred; use local exhaust ventilation to minimize dust
Personal Protective Equipment: Protective gloves (nitrile recommended), safety goggles, laboratory coat, respirator if risk of airborne contamination exists
Hygiene Measures: Remove contaminated clothing immediately; wash hands and face before breaks and end of work; do not eat or drink during handling
Exposure Limits: No occupational exposure limits established; minimize exposure by observed protocols
Appearance: Off-white to pale yellow powder
Odor: Nearly odorless
Odor Threshold: Not established
pH: Not applicable in solid form
Melting Point: 180-190°C
Boiling Point: Decomposes before boiling
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Not easily combustible
Solubility: Slightly soluble in water; soluble in DMSO and methanol
Vapor Pressure: Negligible at room temperature
Relative Density: 1.25–1.35 g/cm³
Partition Coefficient: Data not available
Auto-ignition Temperature: Not available
Decomposition Temperature: Above 190°C
Reactivity: Stable under recommended storage and handling conditions
Chemical Stability: Stable at room temperature and under normal use
Hazardous Reactions: May react with strong oxidizing agents
Conditions to Avoid: Moisture, excessive heat, direct sunlight
Incompatible Materials: Strong acids, strong bases, oxidizers
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides if heated to decomposition
Acute Toxicity: Harmful if swallowed; oral LD50 (rat) estimated from imatinib—between 500 and 2,000 mg/kg
Skin and Eye Contact: Can irritate skin and eyes
Inhalation: Inhalation of dust can cause respiratory tract irritation
Chronic Effects: Prolonged or repeated exposure may affect the liver, kidneys or blood system, matching those seen with imatinib
Carcinogenicity: No data for this metabolite; imatinib is not listed as a carcinogen
Mutagenicity: Not classified as mutagenic; no animal data for this specific metabolite
Reproductive Toxicity: No direct data; potential considered based on parent compound class
Aquatic Toxicity: Harmful to aquatic life with long-lasting effects with reference to parent compound data
Persistence and Degradability: Possible slow degradation in environment; parent compound remains in surface waters and soil for extended periods
Bioaccumulative Potential: Potential to accumulate in aquatic organisms
Mobility in Soil: Tends to stay in upper soil layers
Other Effects: Minimize environmental release
Product Disposal: Dispose of in accordance with national, regional, and local environmental legislation; avoid disposal to drains or the environment
Container Disposal: Triple rinse containers before recycling or disposal; use regulated waste contractor
Precautions: Wear protective equipment in handling waste materials
UN Number: Not applicable (not classified as dangerous for transport)
Proper Shipping Name: N-Desmethyl Imatinib
Transport Hazard Class: Non-hazardous under ADR, IMDG, IATA regulations
Packing Group: Not assigned
Special Precautions: Protect package from physical damage and moisture during shipping; transport in original, labelled containers
Safety, Health and Environmental Regulations: Not listed as a hazardous chemical under key international regulations; subject to workplace safety and pharmaceutical research regulations in many jurisdictions
TSCA Status: Not listed for commercial distribution in the United States
EINECS/ELINCS: Not registered as of last update
Labelling: Provide clear hazard and safety information on all product containers
Other Requirements: Maintain records of use, storage, and disposal as required by local authority
