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Product Name: N-Butyryl Chloride
Synonyms: Butanoyl chloride
Chemical Formula: C4H7ClO
CAS Number: 141-75-3
Relevant Uses: Used as an intermediate in pharmaceuticals, agrochemicals, organic synthesis
Manufacturer/Supplier: Chemical suppliers, specialty chemical distributors
Emergency Contact: Refer to poison control and local emergency number
GHS Classification: Corrosive to skin, severe eye damage, respiratory hazard
Hazard Statements: Causes severe skin burns, eye damage; may cause respiratory irritation; reacts violently with water
Pictograms: Corrosion, Exclamation Mark
Signal Word: Danger
Precautionary Statements: Do not breathe vapors, avoid contact with skin and eyes, wear protective gear
Potential Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Chemical: N-Butyryl Chloride
Concentration: 100% (pure substance)
Impurities: Trace amounts of hydrochloric acid as byproduct; consult specific batch analysis from supplier for details
Molecular Weight: 106.55 g/mol
Eye Contact: Flush eyes with water for at least 15 minutes, keep eyelids open, seek immediate medical care
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, seek medical help if irritation continues
Inhalation: Move to fresh air, provide artificial respiration if breathing stops, call for emergency medical attention
Ingestion: Do not induce vomiting, rinse mouth with water, seek immediate medical advice
Notes for Doctor: Treat symptoms, monitor for respiratory distress, chemical burns, consider irritation to mucous membranes
Suitable Extinguishing Media: Dry chemical, CO₂, alcohol-resistant foam; do not use water on the product itself due to violent hydrolysis
Hazardous Combustion Products: Hydrogen chloride, phosgene, carbon monoxide, carbon dioxide
Protective Equipment: Chemical splash suit, self-contained breathing apparatus, gloves resistant to corrosive chemicals
Special Hazards: Reacts violently with water, releases toxic gases, can form corrosive vapors
Advice for Firefighters: Isolate hazard area, approach from upwind, prevent run-off from entering waterways
Personal Precautions: Evacuate unnecessary personnel, ventilate area, wear chemical-resistant gloves, safety goggles, and respiratory protection
Environmental Precautions: Prevent from entering drains or waterways, contain spill as much as possible
Clean-Up Methods: Neutralize with non-combustible absorbent (like vermiculite) followed by neutralizing agent for acids, place in approved container for disposal
Decontamination: Wash spill area with dilute sodium bicarbonate solution and water
References: Follow local, state, and federal guidelines for spill response
Safe Handling: Operate in a fume hood or with local exhaust ventilation, avoid inhaling vapors, prevent skin or eye contact
Technical Measures: Use corrosion-resistant equipment and containers, inspect seals regularly
Avoid: Moisture, water, open flames, incompatible chemicals such as alcohols, amines, strong oxidizers, strong bases
Storage Conditions: Store tightly closed in a cool, dry, well-ventilated place, away from direct sunlight and water sources
Storage Containers: Use glass or high-quality Teflon-lined containers, avoid metal containers that may corrode
Specific End Uses: Industrial and laboratory use; never consumer applications
Occupational Exposure Limits: No official limit published; minimize all exposures
Engineering Controls: Work in fume hood, use chemical scrubbers for exhaust streams
Respiratory Protection: Full-face respirator with acid gas cartridge or SCBA in case of emergency
Eye Protection: Safety goggles plus full-face shield
Skin Protection: Impervious gloves (nitrile or butyl rubber), lab coat or chemical apron, chemical-resistant boots
Hygiene Measures: Wash hands after handling, do not eat, drink, or smoke in work areas, change contaminated clothing immediately
Appearance: Clear to pale yellow liquid
Odor: Pungent, acrid smell
pH: Reacts with water to form acidic solution
Boiling Point: 104–106°C
Melting Point: -108°C
Flash Point: 19°C
Density: 1.06 g/cm³
Solubility: Reacts vigorously with water; soluble in organic solvents
Vapor Pressure: Approx. 13 mmHg at 20°C
Vapor Density: 3.7 (air = 1)
Partition Coefficient (log Kow): Estimated 1.5
Auto-Ignition Temperature: No data measured
Chemical Stability: Stable under recommended storage conditions, sensitive to moisture
Hazardous Reactions: Releases hydrogen chloride gas when in contact with water or alcohols, reacts with bases, amines, and other nucleophiles
Incompatible Materials: Water, strong bases, alcohols, oxidizers, amines
Decomposition Products: Hydrogen chloride, phosgene, carbon oxides at high temperatures
Polymerization: Does not tend to polymerize
Acute Toxicity: Harmful by inhalation, skin contact, and swallowing; LD₅₀ (oral, rat): 730 mg/kg; LC₅₀ (inhalation, rat): Not well established
Skin Corrosion/Irritation: Rapidly corrosive, can cause ulceration and severe burns
Serious Eye Damage: Causes irreversible injury and possible blindness
Respiratory Sensitization: Vapors are intensely irritating; repeated exposure may cause chronic respiratory disease
Ingestion Hazards: Severe pain, necrosis of mouth, throat, stomach, systemic toxicity
Chronic Effects: No established data, repeat exposure likely to cause chronic damage
Carcinogenicity: No relevant data available
Ecotoxicity: Highly toxic to aquatic organisms; forms hydrochloric acid and butyric acid in water
Persistence and Degradability: Hydrolyzes rapidly in moisture to yield acids
Bioaccumulation Potential: Low, as hydrolysis products do not tend to accumulate in organisms
Mobility in Soil: Not persistent, reacts with soil moisture, mobility mainly determined by hydrolysis rate
Other Adverse Effects: Improper disposal can cause acidification of soil and water bodies
Disposal Methods: Incinerate in approved, properly equipped facility; do not dump in drains or water courses
Container Disposal: Triple rinse empty containers with compatible solvent, dispense rinsate to hazardous waste stream, puncture and dispose in chemical waste
Regulatory Notes: Must comply with federal, state, and local hazardous waste regulations
Precautions: Neutralize residues with sodium bicarbonate under controlled conditions
UN Number: 1760
Proper Shipping Name: Corrosive Liquid, N.O.S. (contains N-Butyryl Chloride)
Transport Hazard Class: 8 (Corrosive)
Packing Group: II (medium danger)
Labels Required: Corrosive
Additional Requirements: Emergency information must accompany shipment, driver must have protective equipment
Environmental Hazards: Marine pollutant where appropriate; do not transport with foodstuffs
Inventory Status: Listed in TSCA, REACH, Canadian DSL, AICS
SARA 313: Not specifically listed
OSHA Status: Corrosive, regulated substance
EPA Status: Regulated as hazardous waste (U-code)
Workplace Classification: Classified for handling only by trained and authorized personnel
Labeling Requirements: Corrosion hazard symbol, risk and safety phrases, manufacturer emergency information
