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Chemical Name: N-Butyl Isocyanate
CAS Number: 111-36-4
Synonyms: 1-Isocyanatobutane
Product Use: Chemical intermediate, research applications
Manufacturer Contact: (Contact details as per supplier)
Emergency Phone: (Emergency response number provided by supplier)
Hazard Classification: Flammable liquid, Toxic by inhalation, Skin and eye irritant, Sensitizer
GHS Symbol: Flame, exclamation mark, skull and crossbones
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage, Fatal if inhaled, Causes serious eye irritation, May cause respiratory irritation, Highly flammable liquid and vapor
Precautionary Statements: Avoid breathing vapor, Use only outdoors or in a well-ventilated area, Wear protective gloves, clothing, eye and face protection, Keep away from heat/sparks/open flames/hot surfaces
Chemical: N-Butyl Isocyanate
CAS Number: 111-36-4
Concentration: ≥99%
Impurities: None reported above hazardous thresholds
Other Components: No additives or stabilizers as standard formulation
Inhalation: Move to fresh air. Provide oxygen if breathing is difficult. Seek immediate medical attention.
Skin Contact: Remove contaminated clothing. Rinse skin with plenty of soap and water for at least 15 minutes. Get prompt medical help.
Eye Contact: Immediately flush eyes with running water for at least 15 minutes, holding eyelids open. Get medical aid right away.
Ingestion: Rinse mouth, do not induce vomiting. Seek medical help immediately.
General Advice: Immediate treatment by trained personnel is needed, especially after inhalation or eye contact.
Suitable Extinguishing Media: Dry chemical, CO₂, alcohol foam. Water may not be effective.
Specific Hazards: Vapors form explosive mixtures with air. Toxic gases such as nitrogen oxides and isocyanate fumes released during burning.
Firefighting Instructions: Wear full protective gear, including self-contained breathing apparatus. Cool containers exposed to heat with water spray.
Unusual Fire/Explosion Hazards: Vapors heavier than air, can travel to ignition sources and flash back.
Personal Precautions: Evacuate area, ventilate, avoid breathing vapors. Wear respirator, gloves, and chemical PPE.
Spill Cleanup: Absorb with earth or sand; collect with explosion-proof tools. Dispose in well-sealed waste containers.
Environmental Precautions: Prevent entry into drains, sewers, waterways.
Decontamination: Wash down area with strong detergent solution after removal, ventilate thoroughly.
Handling: Use only in fume hood or with effective local ventilation. Avoid all personal contact. Ground and bond containers.
Storage: Keep tightly closed in cool, dry, well-ventilated area away from sources of ignition and moisture. Store in original container only.
Other Precautions: Segregate from acids, amines, water, strong oxidizers. Use spark-proof tools and explosion-proof equipment.
Engineering Controls: Chemical fume hood or exhaust system to prevent exposure.
Eye Protection: Tightly sealed chemical splash goggles and faceshield.
Skin Protection: Chemical-resistant gloves (nitrile or butyl), full body suit or lab coat.
Respiratory Protection: NIOSH/OSHA approved respirator for isocyanates where exposure risk exists.
Workplace Hygiene: Avoid eating, drinking, or smoking in work areas; wash hands after handling; remove contaminated clothing immediately.
Exposure Limits: OSHA, NIOSH, or local guidelines for isocyanates apply—typically very low ppm.
Appearance: Clear to pale yellow liquid
Odor: Strong, sharp, pungent
Odor Threshold: Not established
pH: Not applicable
Melting Point/Freezing Point: -94°C
Boiling Point: 160°C
Flash Point: 42°C (Closed Cup)
Evaporation Rate: Not available
Flammability (solid, gas): Flammable liquid
Vapor Pressure: 2 mmHg @ 20°C
Vapor Density: Heavier than air
Relative Density: 0.89 g/cm³
Solubility: Reacts with water, slightly soluble in most organic solvents
Partition Coefficient (n-octanol/water): Not available
Auto-Ignition Temperature: 480°C
Decomposition Temperature: Not specified
Viscosity: Low
Chemical Stability: Stable under recommended storage conditions, sensitive to moisture.
Reactivity: Reacts violently with water, acids, alcohols, amines to release heat and toxic gases.
Hazardous Reactions: Polymerization may occur under uncontrolled conditions, especially in presence of water.
Conditions to Avoid: Heat, flames, sparks, moisture, incompatible materials.
Incompatible Materials: Strong oxidizers, acids, alcohols, amines, water.
Hazardous Decomposition: Toxic fumes of nitrogen oxides, isocyanates, carbon monoxide and dioxide.
Acute Toxicity: Highly toxic by inhalation, ingestion, dermal exposure. Inhalation LC50 (rat): 76 ppm/4hr
Chronic Effects: Can sensitize respiratory tract; repeated or prolonged exposure increases risk of asthma-like symptoms and allergic reactions.
Skin Irritation: Causes severe irritation, may result in blistering or chemical burns.
Eye Contact: Severe eye burns, risk of permanent eye injury.
Ingestion: Severe gastrointestinal damage, systemic toxicity.
Sensitization: May cause allergic skin or respiratory reactions.
Carcinogenicity: Not listed as a known carcinogen by ACGIH, IARC, NTP, or OSHA.
Mutagenicity: Data not conclusive
Reproductive Toxicity: No solid evidence in humans
Ecotoxicity: Highly toxic to aquatic life if released. Disrupts biological wastewater treatment systems.
Persistence and Degradability: Hydrolyzes rapidly in water to form hazardous products.
Bioaccumulative Potential: Low potential; rapidly degraded in environment.
Mobility in Soil: Reacts and binds with soil moisture, unlikely to migrate to groundwater.
Other Adverse Effects: Not expected to contribute directly to ozone depletion; breakdown products may be harmful.
Waste Disposal: Dispose through licensed chemical waste facility. Incinerate contents and container in accordance with regulations.
Container Disposal: Triple-rinse container, puncture and dispose as chemical waste.
Precautions: Avoid inhalation and skin contact when handling waste.
Regulatory Compliance: Follow national, state, and local hazardous waste regulations.
UN Number: UN2480
DOT Proper Shipping Name: Butyl isocyanate
Transport Hazard Class: 6.1 (Toxic substances), 3 (Flammable liquids)
Packing Group: I (high danger)
Labeling Requirement: Toxic, flammable liquid
Environmental Hazards: Dangerous to aquatic environment, take spill precautions during transit
Special Precautions: Keep away from heat, avoid rough handling, ensure containers are sealed tightly.
OSHA: Regulated as highly hazardous chemical
SARA Title III: Section 313—Acute and chronic health hazard
TSCA: Listed
DSL/NDSL (Canada): Listed
EU Regulation: Classified as hazardous per EU CLP Regulation (EC) No 1272/2008
Other State Regulations: Subject to right-to-know, workplace monitoring, and emissions reporting as per region’s legislation.
