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Looking Closer at the Material Safety Data for N-Amyl Propionate

Identification

Substance name: N-Amyl Propionate
Chemical family: Carboxylic acid ester
Molecular formula: C8H16O2
Appearance: Clear, colorless liquid with a fruity odor
Common uses: Solvent for coatings, lacquers, inks, and occasionally as a flavoring or fragrance agent
CAS Number: 624-42-0

Hazard Identification

GHS classification: Flammable liquid (Category 3), Eye irritation (Category 2A), Specific Target Organ Toxicity – Single Exposure (Category 3, narcotic effects)
Label elements: Flammable liquid pictogram, exclamation mark
Main risks: Vapors can catch fire at temperatures above typical ambient levels, moderate eye irritation, inhalation may cause drowsiness or dizziness
Routes of exposure: Skin contact, inhalation, eye contact

Composition / Information on Ingredients

Main component: N-Amyl Propionate, purity often ranges above 95%
Impurities: Small quantities of other amyl esters or propionates may be present depending on production process
Other info: This ester contains both a propionate and an amyl (pentyl) group, contributing to its characteristic odor and flammability.

First Aid Measures

Inhalation: Move to fresh air, support breathing if symptoms show up, seek medical attention if effects persist
Skin contact: Remove contaminated clothing, wash skin well with soap and plenty of water, consult medical professionals if irritation develops
Eye contact: Rinse gently with water for at least 15 minutes, get medical help if pain or redness continues
Ingestion: Rinse mouth, do not induce vomiting, seek prompt medical attention if significant quantity is swallowed or symptoms begin

Fire-Fighting Measures

Suitable extinguishing media: Dry chemical, CO2, foam, or water spray
Fire hazards: Vapors can travel and ignite at a distance from the source, containers may rupture in a fire
Protective gear: Full protective gear and self-contained breathing apparatus for fire responders
Decomposition dangers: Burning can create carbon monoxide, carbon dioxide, and possibly other irritating or toxic fumes

Accidental Release Measures

Containment practices: Evacuate area, eliminate ignition sources, ventilate
Spill cleanup: Absorb with suitable absorbent like sand or vermiculite, collect in closed containers
Personal protection: Gloves, goggles, and adequate ventilation at a minimum
Environmental caution: Prevent runoff to waterways or drains, as aquatic life can be harmed by solvent overexposure

Handling and Storage

Storage recommendations: Keep in tightly sealed containers, store in a cool, well-ventilated place away from heat, sparks, and open flames
Handling practices: Use spark-proof tools, ground all containers during transfer, avoid direct contact with eyes or skin, minimize vapor inhalation
Local exhaust: Good ventilation reduces vapor build-up; splash protection helps keep workers safe

Exposure Controls and Personal Protection

Workplace controls: Make sure there’s adequate local exhaust; keep concentrations below recommended thresholds
Personal protective equipment: Use chemical-resistant gloves, safety goggles, and protective clothing
Respiratory protection: Use approved respirators if vapor concentrations climb above safe levels
Hygiene tips: Wash hands before eating, drinking, or smoking; remove contaminated clothing immediately

Physical and Chemical Properties

Boiling point: About 174–177°C
Melting point: Typically below -60°C
Solubility: Low solubility in water, high solubility in organic solvents
Vapor pressure: Moderate at room temperature
Odor: Fruity, reminiscent of pear or apple
Density: Around 0.87 g/cm³ at 20°C
Flash point: Roughly 49°C (closed cup)

Stability and Reactivity

Conditions to avoid: Heat, sparks, open flame, and static discharge can kick off fire or explosion
Materials to avoid: Strong oxidizing agents can spark hazardous reactions
Decomposition: Hazardous byproducts include carbon oxides under fire situations
Chemical stability: Remains stable in most conditions used for handling and storage if protected from extreme temperatures and incompatible chemicals

Toxicological Information

Acute effects: Short exposures cause moderate eye and mild skin irritation, inhaling high vapor may lead to headache, dizziness, or drowsiness
Chronic effects: Long-term data is limited, but repeated high-dose contact with similar esters links to mild skin defatting or respiratory discomfort
LD50 (oral, rat): Specific toxic dose not widely published, but related esters show LD50 values above 3,000 mg/kg, suggesting relatively low acute toxicity
Carcinogenicity: No evidence from major health agencies indicating cancer risk for this compound

Ecological Information

Aquatic toxicity: Harmful to aquatic organisms at high concentrations
Persistence: Biodegradable in the environment, but breakdown can stress aquatic ecosystems before degradation completes
Bioaccumulation: Estimated to be low, as esters are generally not persistent or prone to build up in the food chain
Movement: Low solubility in water means it mostly binds to organic content or evaporates

Disposal Considerations

Safe disposal methods: Incinerate or send to hazardous waste facility where permitted
Environmental advice: Avoid pouring into drains or waterways; even a small spill in a storm drain reaches rivers fast
Container disposal: Drain container carefully; triple-rinse and send for recycling or proper landfill as local regulations direct

Transport Information

UN Number: 3272
Shipping name: Esters, n.o.s. (N-Amyl Propionate)
Hazard class: Flammable liquid
Packing group: III
Precautions: Label shipments with flammable liquid warnings, keep containers tightly closed and upright during transit, secure loads against tipping or leaking

Regulatory Information

Workplace safety: Listed as regulated for airborne concentration by OSHA and ACGIH in some regions
Environmental: Covered by national water and air pollution acts, but not flagged as a priority pollutant
Labeling needs: Must carry hazard and precautionary statements following GHS guidelines in the EU, US, Canada, and much of Asia
Additional info: Registration and reporting required for industrial users in many jurisdictions through chemical safety programs