© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: N-Acetyl-P-Phenylenediamine
Synonyms: 4-Acetamidophenylenediamine, N-(4-Aminophenyl)acetamide
CAS Number: 101-80-4
Recommended Use: Hair dye ingredient, chemical intermediate, analytical reagent
Supplier/Company Identification: Industrial chemical supplier, details provided onsite per region
Emergency Contact: Refer to national poison control or local emergency number for chemical spills and possible poisoning events
Classification: Acute oral toxicity (Category 4), Eye irritation (Category 2A), Skin sensitization (Category 1)
Hazard Statements: Harmful if swallowed, causes serious eye irritation, may cause an allergic skin reaction
Signal Word: Warning
Hazard Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, fumes, or vapors; wash thoroughly after use; wear protective gloves, eyewear, and clothing; do not eat, drink, or smoke during handling; if on skin: wash with plenty of soap and water; avoid contact with eyes and skin during mixing and handling
Chemical Identity: N-Acetyl-P-Phenylenediamine
Purity: >98%
Impurities: Trace amounts of related aromatic amides or residual solvents from synthesis, typically less than 1%
Molecular Formula: C8H10N2O
Molecular Weight: 150.18 g/mol
Ingredient List: No major stabilizers or extra additives reported by standard suppliers; product handled as the pure compound
Inhalation: Move to fresh air immediately; monitor for breathing difficulties; seek medical attention if symptoms like coughing, dizziness, or shortness of breath develop
Skin Contact: Remove contaminated clothing; rinse skin thoroughly with water for at least 15 minutes; use soap if needed; seek medical advice if redness or irritation persists
Eye Contact: Flush with plenty of water for several minutes (minimum 15 minutes), lifting eyelids occasionally; remove contact lenses if present and easy to do; seek immediate medical help if discomfort persists
Ingestion: Rinse mouth thoroughly with water; do not induce vomiting unless specifically advised by medical personnel; seek immediate medical attention and provide chemical information to first responders
Guidance for Physicians: Monitor for signs of methemoglobinemia, allergic reaction, and treat symptomatically
Suitable Extinguishing Media: Dry chemical, carbon dioxide, or alcohol-resistant foam recommended for small fires, water spray for large areas
Specific Hazards from Combustion: Burning releases toxic fumes including nitrogen oxides, carbon monoxide, and possible traces of ammonia
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear; avoid inhaling combustion gases
Special Procedures: Prevent runoff from entering drains or waterways; cool containers exposed to flames with water mist from a safe distance
Personal Precautions: Wear gloves, goggles, and dust mask or respirator; prevent skin and eye contact; ventilate area well
Environmental Precautions: Prevent entry into drains, watercourses, or soil; inform authorities if spillage reaches water bodies or significant soil contamination occurs
Cleanup Methods: Collect spilled powder using industrial HEPA vacuum or wet brushing; avoid creating dust clouds; place recovered material in sealable containers for proper disposal; clean residues with water and detergent
Handling: Use in a fume hood or well-ventilated area; avoid all direct contact with the substance; wear adequate personal protection; keep away from sources of heat or ignition
Storage: Store in tightly sealed containers in a cool, dry area; segregate from strong oxidizers, acids, or bases; avoid moisture and light exposure; store below 30°C if possible
Incompatible Materials: Strong oxidizing agents may react strongly; avoid mixing with peroxides or nitrates
Exposure Limits: No established ACGIH or OSHA limits, but minimize exposure to dust or vapors wherever possible
Engineering Controls: Work under local exhaust ventilation; use closed-system handling or glove boxes for large quantities
Personal Protective Equipment: Use nitrile or neoprene gloves, chemical splash goggles, and lab coat or apron; use NIOSH-approved dust respirator if dust levels rise; provide eye wash stations and emergency showers near handling areas
Appearance: White to off-white crystalline powder
Odor: Odorless or very faint chemical odor
Melting Point: 166 - 168 °C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water, more soluble in ethanol or organic solvents
Vapor Pressure: Negligible at room temperature
Flash Point: Data not widely available, not expected to be highly flammable under ambient conditions
pH (aqueous solution): Nearly neutral
Partition Coefficient (log Kow): Moderate value, suggesting low bioaccumulation potential
Chemical Stability: Stable under dry, sealed storage and recommended conditions
Conditions to Avoid: Contact with strong oxidizers, acids; excessive heat or prolonged exposure to light
Reactivity: Not reactive under normal laboratory or storage conditions
Decomposition Products: Elevated temperatures or fire can generate toxic gases: carbon monoxide, carbon dioxide, nitrogen oxides, and possible aromatic amines
Acute Toxicity: Oral LD50 values in rats range from 800 to 2000 mg/kg (moderate acute toxicity)
Skin and Eye Irritation: Can cause redness, itching, and allergic reactions after repeated or prolonged exposure
Sensitization: Known skin sensitizer; repeated skin exposure can trigger allergic dermatitis
Carcinogenicity: Not classified as known or probable carcinogen by IARC, NTP, or OSHA; available evidence is limited
Other Effects: Low level of evidence for mutagenicity or reproductive toxicity based on current animal or human data
Ecotoxicity: Moderate toxicity to aquatic organisms based on structure and analog research; classified as harmful to aquatic life in significant quantities
Persistence and Degradability: Not highly persistent; expected to undergo biodegradation under typical environmental conditions
Bioaccumulation: Low potential for accumulation in aquatic food chains
Mobility in Soil: Slight mobility, but adsorption to soil is expected to limit groundwater contamination
Waste Treatment Methods: Collect unused material or residues in closed containers; incinerate at an approved chemical waste facility equipped to handle nitrogen-containing organics
Disposal of Contaminated Packaging: Triple-rinse containers before disposal; dispose of rinsate and packaging as hazardous chemical waste
Regulatory Status: Subject to local and national hazardous waste disposal regulations; do not pour into wastewater or natural environment
UN Number: Not classed by the UN as a dangerous good for road, air, or sea transport under normal conditions
Proper Shipping Name: N-Acetyl-P-Phenylenediamine, chemical, not otherwise specified
Transport Hazard Class: Not regulated as hazardous for most modes of transport
Packaging Requirements: Use standard chemical watertight, sealed containers with clear labeling; protect from moisture and impact
US Regulations: Not specifically listed under SARA Title III Sections 302 or 313; subject to OSHA Hazard Communication Standard, TSCA inventory listing required
EU Regulations: Registered under REACH, requires hazard labeling (H302, H317, H319); not on ECHA Candidate List of SVHCs
Other Authorities: Local workplace safety laws may list as hazardous chemical needing workplace controls; proper training and documentation needed for those handling regularly
