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Product Name: Mosapride Citrate
Chemical Name: 4-Amino-5-chloro-2-ethoxy-N-[(4-(p-fluorobenzyl)oxy]phenyl)benzamide citrate
CAS Number: 112885-42-4
Recommended Use: Pharmaceutical intermediate, prokinetic agent
Manufacturer Information: Contact information of producing company, address, emergency telephone
Synonyms: Mosapride Monohydrochloride Hydrate, Mosapride Citrate Anhydrous
Classification: Eye irritant, slight skin irritant, non-flammable under normal conditions
Hazard Statement: Causes eye irritation, may cause skin reaction after long contact, ingestion may lead to gastrointestinal discomfort
Label Elements: Hazard pictogram: Exclamation Mark, Signal Word: Warning
Precautionary Statement: Avoid contact with eyes or prolonged skin exposure, wash hands thoroughly after handling, do not eat, drink, or smoke during use
Other Hazards: May cause respiratory tract irritation if dust is inhaled, spills can result in slip hazards.
Chemical Identity: Mosapride Citrate
Purity: >99% by HPLC
Impurities: Trace synthetic by-products <1%
Molecular Formula: C21H25ClFN3O8
Molecular Weight: 501.89 g/mol
Other Components: None of major toxicological significance identified.
Inhalation: Move individual to fresh air, keep comfortable for breathing, seek medical attention with persistent symptoms
Skin Contact: Remove contaminated clothing, wash affected area with soap and water; medical attention needed for persistent irritation
Eye Contact: Rinse eyes with tepid water for several minutes, remove contact lenses if present and easy, continue rinsing, seek medical attention upon continued irritation
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical advice, offer water if fully conscious
Most Important Symptoms: Mild to moderate eye or skin irritation, cough, stomach discomfort
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide
Unsuitable Media: Do not use high-pressure water jet as dust dispersal may occur
Specific Hazards: May liberate toxic fumes under fire conditions, including nitrogen oxides, chlorine, fluorine compounds, carbon oxides
Protective Equipment: Firefighters should use self-contained breathing apparatus and protective clothing
Precautions: Avoid inhalation of combustion products, evacuate area, control runoff from firefighting to prevent environmental contamination
Personal Protection: Wear protective gloves, goggles, suitable mask; avoid formation of dust clouds, ventilate area
Environmental Precautions: Prevent further leakage, do not allow product to enter waterways, soil, or drains
Methods for Cleanup: Scoop up spilled product using non-sparking tools, wet down dust if appropriate, place in labeled waste container
Handling Spills: Dispose collected material as hazardous waste per local regulation, wash spill site with plenty of water once cleanup is complete
Handling: Minimize dust generation, use in well-ventilated area, avoid inhalation and skin contact, wash hands before breaks and after work
Storage Conditions: Store in a tightly closed, clearly labeled container under cool, dry, well-ventilated, away from incompatible materials such as oxidizers or strong acids
Incompatibilities: Keep away from foodstuffs, animal feed, and direct sunlight
Special Notes: Avoid excess moisture and temperature fluctuation to maintain product integrity.
Engineering Controls: Use fume hood or local exhaust ventilation for large-scale processing, keep airborne concentrations low
Workplace Exposure Limits: Not established for Mosapride Citrate; keep below laboratory exposure limit where available
Respiratory Protection: NIOSH-approved respirator if ventilation inadequate or exposure risk from dust
Hand Protection: Chemical-resistant gloves recommended
Eye Protection: Safety glasses or chemically splash-proof goggles
Skin Protection: Protective clothing, lab coat, closed-toe shoes
Hygienic Practices: No eating or drinking in work area, wash thoroughly after handling
Appearance: White to off-white crystalline powder
Odor: Not significant
pH: Solution in water mildly acidic
Melting Point: 165-170°C
Boiling Point: Not applicable (decomposes)
Solubility: Soluble in water, alcohol, and DMSO
Particle Size: Some grades <10 microns
Vapor Pressure: Not measurable at room temperature
Flash Point: Not flammable
Explosive Properties: Low hazard
Other Data: No unusual properties under standard laboratory conditions
Chemical Stability: Stable under recommended storage and handling conditions
Conditions to Avoid: Excessive heat, moisture, direct light exposure
Incompatible Materials: Strong oxidizers, strong acids/bases
Hazardous Decomposition: Under combustion: carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride, hydrogen fluoride
Polymerization: Not known to occur
Acute Toxicity: Oral (rat) LD50 >2,000 mg/kg; low acute toxicity reported in animal studies
Skin Corrosion/Irritation: Mild skin irritant
Eye Damage/Irritation: Eye irritant
Sensitization: No sensitizing effects recorded, but minimize contact
Chronic Effects: No chronic toxicity data available for humans; long-term exposure in animals: liver and gastrointestinal effects at high dose
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified based on present data
Route of Exposure: Inhalation, ingestion, skin, and eye contact must be avoided
Symptoms: May cause nausea, mild respiratory irritation, headache if overexposed
Ecotoxicity: Data limited, no known acute aquatic toxicity at trace concentrations; avoid uncontrolled release to environment
Mobility: Limited by low volatility and solubility in water
Persistence/Degradability: Expected to be slowly biodegradable under environmental conditions
Bioaccumulation: No significant bioaccumulation potential anticipated based on available studies
Other Adverse Effects: Prevent contamination of surface water or soil due to its pharmaceutical activity
Waste Treatment Methods: Dispose of product through licensed chemical waste contractor
Container Disposal: Triple rinse empty containers, offer for recycling if possible, treat as hazardous chemical waste
Special Instructions: Do not dispose into municipal waste or drains, follow all regional regulations for pharmaceuticals
Recommended Handling: Isolate waste in closed, labeled container until proper disposal
UN Number: Not classified as a dangerous good for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not assigned
Packing Group: Not classified
Sea Transport (IMDG): Not regulated
Air Transport (IATA): Not regulated
Special Precautions: Protect cargo from moisture and temperature extremes; use sealed packaging to prevent dust release
Regulatory Status: Product as a pharmaceutical intermediate may be regulated under pharmaceutical laws, check regional requirements
TSCA Listing: Not listed for specific chemical; research and development uses only
OSHA / WHMIS Classification: Hazardous by WHMIS criteria for health effects (irritant)
EINECS/ELINCS: Not listed
Other Regulations: Always reference national chemical inventories and workplace safety legislation; observe all local, state, federal and international regulatory obligations for chemical and pharmaceutical safety management
