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Product Name: Monomethyl Auristatin E
Chemical Formula: C39H67N5O7
Synonyms: MMAE, Auristatin E methyl ester
CAS Number: 646502-53-6
Intended Use: Research, development of antibody-drug conjugates in oncology
Manufacturer: Listed on supplier’s documentation
Emergency Phone: Refer to institution’s safety protocol
Recommended Use: Laboratory research, not for human or veterinary therapeutic use
GHS Classification: Acute Toxicity (Oral Category 2), Skin Irritation (Category 2), Eye Irritation (Category 2A), Specific Target Organ Toxicity (Category 2)
Hazard Statements: Toxic if swallowed; causes skin irritation; causes serious eye irritation; suspected of causing genetic defects; may cause damage to organs through prolonged or repeated exposure
Pictograms: Skull and Crossbones, Exclamation Mark, Health Hazard
Signal Word: Danger
Precautionary Statements: Avoid all contact with skin, eyes, and clothing; wear protective gloves and eye protection; use only in well-ventilated areas; do not eat, drink, or smoke when handling
Route of Exposure: Inhalation, ingestion, skin and eye contact
Chemical Name: Monomethyl Auristatin E
Concentration: ≥98% purity
Impurities: Residual solvents, trace related substances (<1%)
Molecular Weight: 717.99 g/mol
Index Number: Not assigned
Other Ingredients: None identified; compound used as supplied without additional formulation components
General Advice: Remove any contaminated clothing; seek immediate medical attention for any sign of discomfort
Inhalation: Move to fresh air, keep at rest, ensure unobstructed breathing, seek prompt medical advice
Skin Contact: Rinse under running water for at least 15 minutes, wash with mild soap, medical evaluation required
Eye Contact: Flush cautiously with water for 15–20 minutes, remove contact lenses if present and easy to do, seek urgent ophthalmological assessment
Ingestion: Rinse mouth, do not induce vomiting, immediate hospital intervention necessary
Most Important Symptoms: Nausea, abdominal pain, skin or eye irritation, weakness, potential for acute toxicity
Suitable Extinguishing Media: Carbon dioxide, water spray, dry chemical, foam
Unsuitable Extinguishing Media: Avoid high-pressure streams which could spread contaminated material
Special Hazards: Combustion produces irritating, toxic fumes including nitrogen oxides, carbon oxides
Protective Equipment: Firefighters wear self-contained breathing apparatus, full protective clothing
Firefighting Procedures: Move unaffected containers away from fire zone if safe, prevent contaminated runoff
Personal Precautions: Prevent contact with skin, eyes, clothing; evacuate unnecessary personnel
Protective Equipment: Chemical-resistant gloves, safety goggles, disposable lab coats, appropriate respiratory protection if aerosol risk present
Environmental Precautions: Prevent product from entering drains, waterways, or soil
Cleanup Procedures: Absorb spills with inert material like absorbent pads; collected material placed in clearly labeled chemical waste containers; ventilate affected area; decontaminate surfaces with 10% bleach solution followed by detergent wash
Handling: Avoid aerosol and dust generation, work in certified chemical fume hood, minimize personal exposure, handle only by trained personnel
Hygiene: Wash hands thoroughly after handling, do not eat, drink, or smoke in areas where this compound is used, keep work surfaces clean
Storage Conditions: Store at -20°C or lower, tightly sealed in light-protective container, away from incompatible substances such as strong oxidizers or acids
Container Requirements: Use original packaging or compatible chemical-resistant vials, label with hazard information and expiration date; monitor for signs of degradation before each use
Occupational Exposure Limit: No established OEL; minimize exposure as compound is highly toxic at low concentration
Engineering Controls: Use Class II biosafety cabinet; use ventilation systems that filter air before discharge
Personal Protective Equipment: Nitrile or latex gloves (double-gloving recommended), disposable lab coat or chemical-resistant apron, splash-proof safety goggles, respiratory protection with HEPA filter if powder or aerosols possible
Environmental Exposure Controls: Implement local containment for waste and air emissions; routine monitoring of lab surface contamination
Appearance: Off-white to pale yellow powder
Odor: No significant odor
pH: Not applicable; compound is not supplied in aqueous solution
Melting Point/Range: Not defined, decomposes before melting
Boiling Point: Not applicable (decomposes)
Solubility: Soluble in DMSO, DMF; limited solubility in water
Density: Not determined
Flash Point: Not flammable under normal conditions
Partition Coefficient: High logP, indicating hydrophobic character
Chemical Stability: Stable when stored at recommended conditions; susceptible to photodegradation and thermal decomposition
Reactivity: Low, no hazardous reactions expected under normal laboratory conditions
Conditions to Avoid: Light, heat above 25°C, strong oxidizing agents
Incompatible Materials: Strong acids, strong bases, oxidizing reagents
Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, other organics based on incomplete combustion
Acute Toxicity: Highly toxic by ingestion, may cause life-threatening effects at low doses (LD50 oral rat <5 mg/kg)
Chronic Toxicity: Risk of cumulative organ toxicity including neurotoxicity, hepatotoxicity, nephrotoxicity
Carcinogenicity: Not classified as carcinogen by IARC, US NTP, or OSHA, but genotoxicity data are limited
Mutagenicity: Evidence from structural analogs suggests potential genotoxic risks
Reproductive Toxicity: Unknown; avoid exposure during pregnancy
Routes of Exposure: Absorbed through skin, mucous membranes, inhalation, ingestion
Target Organs: Central nervous system, liver, kidneys, immune system
Symptoms of Exposure: Nausea, dizziness, fatigue, skin and eye irritation, respiratory distress, potential for delayed effects
Aquatic Toxicity: Very toxic to aquatic life with long lasting effects; avoid release to environment
Persistence and Degradability: Not rapidly degradable under standard environmental conditions; potential for persistence in soil and water
Bioaccumulation Potential: High based on physical properties; risk of bioaccumulation in aquatic organisms
Mobility in Soil: Expected to be immobile in soil matrices due to hydrophobic character
Other Adverse Effects: No further relevant ecological data available
Waste Treatment Methods: Dispose of as hazardous organic chemical waste; incinerate in properly permitted facility with afterburner and gas scrubber
Container Disposal: Triple-rinse containers, then dispose according to institution guidelines for hazardous laboratory waste
Precautions: Do not release to municipal or public waste streams
Contaminated Packaging: All contaminated packaging and materials should be treated as hazardous and handled by specialized waste contractors
UN Number: 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains Monomethyl Auristatin E)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Environmental Hazards: Marine pollutant; not to be shipped with foodstuffs or animal feed
Transport Precautions: Ship in secondary containment; handle by experienced personnel with knowledge of toxic chemical protocols
Regulatory Compliance: Conform to IATA, IMDG, ADR requirements for toxic and environmentally hazardous substances
Labelling: Must be clearly labelled as toxic and hazardous per OSHA Hazard Communication Standard and EU CLP regulation
Inventory Status: Restricted, typically only available to authorized research institutions
Relevant Regulations: Subject to US TSCA, EU REACH, and local regulations controlling use of cytotoxic substances
Workplace Control: Employers required to implement chemical hygiene plan, exposure monitoring, and training under OSHA 29 CFR 1910.1200
Other Regulatory Considerations: DEA schedule not assigned; local permits may be necessary for possession or use
